Browse our anti-AXL (AXL) Antibodies

Human AXL Receptor tyrosine Kinase (AXL) interaction partners

1. identify the receptor tyrosine kinase Axl as a novel target of ZNF224 transcriptional repression activity.

2. Findings suggest that METTL3 plays very important oncogenic roles in ovarian carcinoma development and/or aggressiveness by stimulating AXL translation and EMT.

3. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing.

4. This study demonstrates that motility behavior of AXL-expressing tumor cells can be elicited by Gas6-bearing apoptotic bodies generated from tumor treatment with therapeutics that produce killing of a portion of the tumor cells present but not all, hence generating potentially problematic invasive and metastatic behavior of the surviving tumor cells

5. Results show that average methylation in AXL at birth was associated with higher risk for asthma-related phenotypes in childhood, especially wheezing. The effects of average AXL methylation on wheezing symptoms were magnified in girls compared to boys.

6. we identified YAP-driven AXL overexpression as a mechanism of resistance to EGFR TKIs in lung cancer cells.

7. The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways.

8. AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy in colon and breast cancer

9. Taken together, these findings suggest that AXL most likely serves as an attachment factor for Zika virus on the cell surface, and that productive infection requires endocytosis and delivery of the virus to acidified intracellular compartments.

10. serum Axl shows high diagnostic accuracy at early stage hepatocellular carcinoma as well as cirrhosis

11. AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6.

12. Results indicate AXL receptor tyrosine kinase (AXL) as an important mediator of docetaxel resistance in prostate cancer.

13. AXL promotes epithelial cell efferocytosis in a tyrosine kinase-dependent manner.AXL role in AKT-dependent drug resistance.

14. The plasma concentrations of Gas6 and Axl are lowered in rheumatoid arthritis patients.

15. The anti-AXL antibody 20G7-D9 represents a promising therapeutic strategy in triple-negative breast cancer with mesenchymal features by inhibiting AXL-dependent Epithelial-Mesenchymal Transition, tumor growth, and metastasis formation

16. Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs

17. our data point to a targetable Axl-PI3 kinase-PD-L1 axis that is highly associated with radiation resistance

18. AXL+ and GAS6+ expression is relevant to a poor prognosis in resected lung adenocarcinoma (AD)patients at stage I. AXL/GAS6 might serve as crucial predictive and prognostic biomarkers and targets to identify individuals at high risk of post-operative death.

19. report that Axl regulates FGFR signaling via complex formation with FGFR3

20. AZD7762 inhibits the proliferative/metastatic activity of breast cancer cells through the suppression of cellular AXL signaling events including anti-apoptosis, migration, invasion, and angiogenesis.

Mouse (Murine) AXL Receptor tyrosine Kinase (AXL) interaction partners

1. These results suggest a novel role for Axl in suppressing antigen presentation through MHCI, and enhancing cytokine release, which promotes a suppressive myeloid microenvironment.

2. AXL is not the key receptor for Zika virus infection using an Axl knockout mouse model.

3. present findings indicate that MafB enhances efferocytosis by regulating Axl expression in RAW264.7 macrophages

4. Study found that hematopoietic cell-Axl deficiency in Western-type diet-fed Ldlr(-/-) mice does not affect the progression of advanced atherosclerosis or lesional processes associated with TAM receptor signaling.

5. This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure.

6. These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.

7. GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.

8. Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.

9. reciprocal activation of Axl and Mer receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

10. Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.

11. Axl, Mertk and Tyro3 receptors are not required for Zika virus entry and infection.

12. Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.

13. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.

14. Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.

15. Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.

16. results establish TAM receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

17. These results suggest that TAM receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.

18. Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression.

19. The results indicate that Axl and Mer receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.

20. Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1-SOCS1 balance in vein graft intima and progression of the remodeling.

Cow (Bovine) AXL Receptor tyrosine Kinase (AXL) interaction partners

1. activation of receptor tyrosine kinase Axl inhibits the osteogenic differentiation of vascular pericytes.