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AZD7762 inhibits the proliferative/metastatic activity of breast cancer cells through the suppression of cellular AXL signaling events including anti-apoptosis, migration, invasion, and angiogenesis.
BGB324 does not inhibit BCR-ABL1 and consequently inhibits chronic myeloid leukemia (CML)independent of BCR-ABL1 mutational status. Our data show that Axl inhibition has therapeutic potential in BCR-ABL TKI-sensitive as well as -resistant CML and support the need for clinical trials
Results show that AXL is upregulated in endometrial cancer tissues and indicate that AXL promotes invasion and migration of endometrial cancer cells.
these results suggest that HOTAIR promotes renal cell carcinoma (show MOK Proteins) (Rcc (show XRCC1 Proteins)) tumorigenesis via miR (show MLXIP Proteins)-217/HIF-1alpha (show HIF1A Proteins)/AXL signaling, which may provide a new target for the diagnosis and therapy of Rcc (show XRCC1 Proteins) disease.
The expression of MerTK (show MERTK Proteins) and AxlTK varied according to the deposition of immunoglobulin and complements on glomeruli. Both MerTK (show MERTK Proteins) and AxlTK expressions were increased on glomeruli and varied according to pathological classifications.
High expression level of AXL is associated with lung adenocarcinoma.
AXL is a strong adverse prognostic factor for esophageal squamous cell carcinoma
Our data demonstrate that AXL is a crucial therapeutic target of carvacrol-induced inhibition of NSCLC cell proliferation and migration.
These results show that TYRO3 (show TYRO3 Proteins), AXL and GAS6 (show GAS6 Proteins) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
miR (show MLXIP Proteins)-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL and the interference with the activation of downstream signaling.
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (show GAS6 Proteins)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (show NLRP3 Proteins) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (show ERH Proteins) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (show MERTK Proteins) and Tyro3 (show TYRO3 Proteins) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (show ADAM10 Proteins) and TACE (ADAM17 (show ADAM17 Proteins)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (show GAS6 Proteins)/Axl and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
activation of receptor tyrosine kinase (show RET Proteins) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog