Browse our anti-BDNF (BDNF) Antibodies

Human Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Study present evidence for a feed-forward loop whereby adrenergic signaling leads to increased tumoral innervation. In response to catecholamines, tumor cells produced BDNF in an ADRB3/cAMP/Epac/JNK-dependent manner. Elevated BDNF levels in the tumor microenvironment increased innervation by signaling through host neurotrophic receptor tyrosine kinase 2 receptors.

2. The genetic variant of BDNF rs6265G>A is shown to be associated with decreased risk of chronic postsurgical pain.

3. coexpression of BDNF and TrkB is associated with poor prognosis in small cell lung cancer patients

4. Studied plasma levels of brain derived neurotrophic factor (BDNF), nutritional status, and physical activity level in children with mild to severe CP.

5. REVIEW: role of the brain-derived neurotrophic factor (BDNF) in neurodegenerative processes and in the neuroregeneration mechanisms induced by increased physical activity

6. BDNF and Tau as biomarkers of severity in multiple sclerosis

7. Study supports the validity of BDNF IV promoter hypermethylation as a biomarker for borderline personality disorder in saliva.

8. BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to fibromyalgia in a Korean population.

9. A cross-sectional study was performed in which the expression of TrkA, TrkB, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) was analyzed by immunohistochemistry of 154 melanoma samples. We investigated NT/TRK expression associations with prognostic factors for melanoma, relapse-free survival (RFS), and overall survival (OS).

10. found an association of both BDNF Met allele and lower brain BDNF protein level in the anterior cingulate cortex and caudal brainstem with major depressive disorder, and there were lower BDNF levels in association with a reported history of childhood adversity and suicide as cause of death; but did not find BDNF brain levels associated with genotype.

11. In systematic review, BDNF Val66Met polymorphism correlates with improved executive function while Val/Val homozygotes exhibited improved neurocognitive memory.

12. Study found that lower dietary quality, and surprisingly, higher BDNF levels, were associated with increased depression risk. A Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.

13. Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.

14. This is the first study showing the significant association between the BDNF rs6265 AA (Met/Met) genotype and overweight/obesity in Mexican pediatric population.

15. Results show that BDNF C270T polymorphisms may be associated with late onset Alzheimer's disease (LOAD) and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.

16. Intracellular processing and efficacy was shown in HEK293 cells and SH-SY5Y neuroblastoma cells using plasmid DNA and after incorporating the TrkB-2A-mBDNF into an AAV2 vector. Increased BDNF/TrkB-mediated intracellular signaling pathways were observed after AAV2 vector transfection while increased TrkB phosphorylation could be detected in combination with neuroprotection from hydrogen peroxide-induced oxidative stress.

17. rs10767664 variant of BDNF gene modify anthropometric and biochemical changes after weight loss with a hypocaloric diet.

18. Epistasis between BDNF and HTR1A may contribute to the multifactorial risk for affective disorders.

19. This study demonstrated that Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity.

20. The study revealed a lack of association of the BDNF rs6265 variant with obesity and obesity-related traits. On the other hand, the interaction between the BDNF rs6265 and overweight/obesity was found to be significantly associated with some of the obesity-related anomalous traits.

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. The BDNF Met prodomain renders ventral CA1 - prelimbic projection neurons underdeveloped, preventing their capacity for subsequent circuit modulation necessary for fear extinction.

2. BDNF gene in mice fed high-fat diet was under-expressed by 0.30 fold with respect to chow-fed mice after 3 months of dietary intervention.

3. Results provide evidence of a causal relationship between reduced BDNF function in hippocampus and the anxiety susceptibility of aged mice.

4. Chronic unpredictable mild stress (CUMS) induced depressive-like behaviors and stimulated changes in brain regions expressing different BDNF levels. Depressive-like behaviors and region-specific BOLD activity in BDNF(tm1Krj/J) mice were consistent with those in wild-type CUMS-exposed mice. Findings suggested a potential central role of BDNF expression in functional changes in the brain.

5. Central BDNF, especially subfornical organ BDNF is involved in the maintenance of basal blood pressure and in augmentation of hypertensive response to angiotensin II.

6. The data of this study demonstrated that 24 h after fear conditioning, BDNF+/- mice exhibited an impaired fear memory expression.

7. This study demonstrated that Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.

8. Deficiency in MyD88 was associated with decreased BDNF expression. Furthermore, the authors identified a valid kappaB-binding site in the BDNF promoter, consistent with activation of NF-kappaB induced by inflammation.

9. The activation of PKCalpha during plasticity requires both NMDA receptor Ca(2+) flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in their spatiotemporal scales of signaling

10. BDNF val66met polymorphism modulates the effects of developmental EtOH exposure on hippocampus and anxiety-like behavior.

11. Results show that BDNF haploinsufficiency substantially decreases the neuroprotective effect of the steroid mifepristone on Purkinje neurons. This suggests that a full expression of BDNF is critical to prevent the neurotoxicity induced by the GABAergic network activity.

12. Closer examination of genes implicated in the mechanisms of neuroplasticity, such as the NMDA and AMPA subunits and the BDNF pathway, reveal how wild-type mice upregulate many of these genes in response to stress, but Met allele carriers fail to do so.

13. This study found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.

14. CA3-specific deletion of BDNF results in deficits in circuits that process social cues from familiar conspecifics.

15. findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance.

16. It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.

17. High BDNF expression is associated with anxiety and memory disorders in Huntington's disease.

18. These data suggested an anxiogenic- and antidepressant-like phenotype of ELA2 knockout, possibly associated with increased levels of BDNF in the prefrontal cortex.

19. Prep1 deficiency alters olfactory morpho-functional integrity and olfaction-mediated eating behavior by affecting BDNF-TrkB signaling.

20. Electroconvulsive therapy in an animal model of depression increases BDNF expression in the cerebral cortex.

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]

2. BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.

3. One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.

4. These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals

5. BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

6. Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.

7. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

8. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

9. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.

10. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

11. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

3. activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.

4. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .

5. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

6. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.

7. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

8. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

9. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

10. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

11. PACAP stimulates the expression of BDNF transcript IV.

12. The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals

2. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

3. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.

2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.

3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.