Browse our BDNF Proteins (BDNF)

Human Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. BDNF mRNA expression and DNA methylation (show HELLS Proteins) of seven CpG sites were not associated with schizophrenia after accounting for age and PMI (show MPI Proteins) effects. BDNF mRNA expression and DNA methylation (show HELLS Proteins) were not altered by Val66Met after accounting for age and PMI (show MPI Proteins) effects. Schizophrenia risk was not associated with differential BDNF mRNA expression and DNA methylation (show HELLS Proteins).

2. antisense BDNF is lowly expressed in retinoblastoma, and may be used as a prognostic biomarker in RB. Upregulating BDNF-AS has inhibitory effect on RB development, probably through the suppression of cell-cycle transition

3. BDNF Val66Met is a determinant of motor skill learning after stroke.

4. Findings suggested an involvement of BDNF Val66Met polymorphism after childhood trauma in terms of risk for schizophrenia symptoms.

5. Low plasma BDNF level is associated with hyperglycemia.

6. There was no evidence to support that BDNF Val66Met or childhood adversity alone predicted treatment response to physical exercise and internet-based cognitive behavioural therapy.

7. SNPs of the BDNF gene affect memory encoding during spatial navigation.

8. an ApoE2 or ApoE3 mediated positive regulation of BDNF may be protective while ApoE4 related defects in BDNF processing could lead to Alzheimer's disease pathophysiology.

9. Maternal age, early pregnancy BMI, gestational age, and the presence of moderate antepartum depressive symptoms were statistically significantly associated with early pregnancy serum BDNF concentrations in low-income Peruvian women. Biological changes of CRP (show CRP Proteins) during pregnancy may affect serum BDNF concentrations.

10. miR (show MLXIP Proteins)-140/BDNF axis regulates normal human astrocyte proliferation through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway; miR (show MLXIP Proteins)-140 could inhibit BDNF, IL-6 (show IL6 Proteins) and TGF-alpha (show TGFA Proteins) expression in Lipopolysaccharide-induced in vitro injury model.

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. There was a significant decrease in the BDNF protein expression along with an increase in the mRNA expression of CRH (show CRH Proteins), NR3C1 (show NR3C1 Proteins), CART, and NPY (show NPY Proteins) in intact females

2. Daily OMR (show ATP5A1 Proteins) testing during the critical period leads to general visual function improvements accompanied by increased DA and BDNF in the retina, with this process being requisitely mediated by TrkB (show NTRK2 Proteins) activation

3. The changes in the expression patterns of proBDNF, BDNF, and their receptors under the influence of chronic alcohol consumption in the depressive ASC (show STS Proteins) strain and nondepressive CBA strain mice are different.

4. These results suggest that BDNF is implicated in MDMA-induced dependence and psychosis by activating the midbrain serotonergic and dopaminergic neurons.

5. newborn neurons improve social recognition persistence through a BDNF-independent mechanism.

6. Study shows long-term physical exercise in mice led to a significant increase in the synthesis and release of brain derived neurotrophic factor along with an alteration in the morphology of astrocytes in the dentate gyrus.

7. Mice exposed to aggressive confrontations exhibited a similar pattern of species-typical aggressive and non-aggressive behaviors on the first and the last session. Repeated aggressive confrontations promoted an increase in plasma corticosterone. Repeated sessions of social instigation or aggressive confrontation did not alter BDNF concentrations at the prefrontal cortex and hippocampus.

8. High-intensity acute exercise increased total Bdnf mRNA in hippocampus of sedentary mice.

9. Thus, the expression of BDNF in the hippocampal CA1 (show CA1 Proteins) region has the potential to improve fear and object location memory in wild type mouse strains when the region and expression levels of BDNF are well controlled.

10. Study demonstrates the importance of 14,15-EET-mediated production of astrocyte-derived brain derived neurotrophic factor for enhancing viability of astrocytes and protecting neurons from the ischaemic injury and provides insights into the mechanism by which 14,15-EET is involved in neuroprotection.

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. One of the modulators of TOR (show FRAP1 Proteins) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Proteins) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Proteins) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.

2. These results suggest an involvement of the BDNF/TrkB (show NTRK2 Proteins) system in the regulation of food intake and energy balance in zebrafish, as in mammals

3. BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

4. Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.

5. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.

6. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

7. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.

8. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

9. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

3. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .

4. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

5. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.

6. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

7. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

8. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

9. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

10. PACAP stimulates the expression of BDNF transcript IV.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

2. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

3. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).

2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.

3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.