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Human BDNF Protein expressed in Wheat germ - ABIN1346621
Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012
Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062
Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014
BDNF has a role in activity-dependent neural plasticity processes of the hippocampus and amygdala, implicated in long-term learning and memory.
functional interaction between BDNF/TrkB (show NTRK2 Proteins) and PTX3 (show PITX3 Proteins) enhances the osteolysis of bone metastatic gastric cancer.
Study found that the BDNF gene Val66Met polymorphism was associated with hippocampal volume and cortical surface area and cortical thickness in frontal, temporal, and occipital cortices in school-aged children.
Our study shows that carriers of the BDNF Met allele are more vulnerable to the impact of prolonged wakefulness and the biological night on a critical component of executive function, as measured by response inhibition on the Stroop task.
BDNF rs6265 polymorphisms modulate entorhinal cortex-interconnected clusters and the valine allele was associated with stronger structural covariance patterns that determined the cognitive outcomes.
Older patients with bipolar disorder (BD) have lower serum levels of BDNF compared with similarly aged comparators. These effects appear to be specific to patients with BD type I.
Depression level of patients with asthma, negatively correlated with BDNF mRNA expression.
Data show that rs6265, rs11030104 and rs10767664 in brain derived neurotrophic factor (BDNF) were associated with a decreased risk of heroin addiction.
Serum BDNF levels seem to be one of the indicators of schizophrenia and its progress; nevertheless, we still do not have sufficient information about this neurotropic factor
BDNF G196A variant plays a major role in ischemic stroke occurrence and consequences in Iranian patients.
Study demonstrates the importance of 14,15-EET-mediated production of astrocyte-derived brain derived neurotrophic factor for enhancing viability of astrocytes and protecting neurons from the ischaemic injury and provides insights into the mechanism by which 14,15-EET is involved in neuroprotection.
Orthopedic surgery modulates the expression of neuropeptide Y (show NPY Proteins) and BDNF at the spinal and hippocampal levels.
treating BACHD cortical neurons with ApiCCT1 prevented BACHD striatal neuronal atrophy by enhancing release of BDNF that subsequently acts through tyrosine receptor kinase B (TrkB (show NTRK2 Proteins)) receptor on striatal neurons. Our findings are evidence that TRiC (show MARVELD2 Proteins) reagent-mediated reductions in mHTT enhanced BDNF delivery to restore the trophic status of BACHD striatal neurons.
BDNF in the lower parts of the auditory system drives auditory fidelity along the entire ascending pathway up to the cortex by increasing inhibitory strength in behaviorally relevant frequency regions.
Results highlight the biological significance of alternative brain-derived neurotrophic factor transcripts and provide evidence that individual isoforms serve distinct molecular and behavioral functions.
A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B (show NTRK2 Proteins) signaling in the hippocampus and enhances depression-like behaviors later in life.
Deletion of Bdnf in DRG neurons leads to a temporary dysregulation of miR-1.
Excitatory synaptic activation-dependent up-regulation of XBP1 (show XBP1 Proteins) directly facilitated transcriptional activation of BDNF. BDNF in turn drove its own expression via IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) pathway in a protein kinase A-dependent manner. Exogenous treatment with BDNF promoteSynaptic activity- and BDNF-dependent distinct activation of dendritic IRE1 (show ERN1 Proteins)-XBP1 (show XBP1 Proteins) cascade drives BDNF expression in cell soma and may be involved in dendritic extension.
We hypothesize that BDNF in the developing brain regulates fear circuit plasticity during a sensitive period in early adolescence, and alterations in BDNF expression (genetic or environmental) have a persistent impact on fear behavior and fear-related disorders.
High BDNF expression is associated with neuropathic pain.
One of the modulators of TOR (show FRAP1 Proteins) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Proteins) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Proteins) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Proteins) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor