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Human BDNF Protein expressed in Wheat germ - ABIN1346621
Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012
Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062
Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014
upregulation of PAI-1 (show SERPINE1 Proteins) may be a critical mechanism underlying insufficient neurotrophic support and increased neurodegeneration associated with AD. Thus, targeting BDNF maturation through pharmacological inhibition of PAI-1 (show SERPINE1 Proteins) might become a potential treatment for AD.
This study shows the genetic correlates of early trauma in a group of schizophrenia patients (BDNF Met carriers).
This study demonstrated significant differences in the blood levels of BDNF between people with epilepsy and healthy subjects.
Study shows that brain-derived neurotrophic factor concentrations in serum and peritoneal fluid were significantly higher in women with endometriosis with pain compared to women with endometriosis without pain.
Met allele of the Val66Met polymorphism in brain derived neurotrophic factor is associated with lower BMI-SDS (show SDS Proteins) in children
platelet BDNF and SERT (show SLC6A4 Proteins) do not specifically underlie psychosocial deficits in stage Huntington's Disease, while higher BDNF storage in delayed mild symptoms
polymorphisms in BDNF gene including rs925946, rs10501087, rs6265 and rs988712 can be considered as genetic determinants of obesity (systematic review and meta-analysis).
Single nucleotide polymorphism found in the BDNF-AS (BDNF antisense RNA [nonprotein coding]) gene may be related to the decreased plasma brain derived neurotrophic factor levels found in frail elderly people.
The pattern of low BDNF and high inflammation in MDD may be influenced by the Val66Met polymorphism; the association of a polymorphism in the BDNF gene with inflammatory markers in addition to BDNF levels suggests an interaction between these systems.
Angiogenin (show ANG Proteins) contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF).
These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 (show HSPH1 Proteins) expression.
In a model of traumatic brain injury, transcranial ultrasound stimulation increases brain BDNF levels.
Results suggest that brain derived neurotrophic factor (BDNF) activation in the nucleus accumbens (NAc) may overcome memory and plasticity deficits linked to Actl6a (show BAF53A Proteins) protein (BAF53b (show ACTL6B Proteins)) mutations.
Upregulating BDNF-AS inhibits osteogenesis, possibly through inverse regulation on BDNF and osteogenic signaling pathways
miR (show MLXIP Proteins)-322 promotes Tau phosphorylation via negatively controlling BDNF-TrkB (show NTRK2 Proteins) receptor activation
BDNF preserves intestinal mucosal barrier function and alters gut (show GUSB Proteins) microbiota in mice.
Results demonstrate that heterotrimeric Galphai1 and Galphai3 (show GNAI3 Proteins) proteins are essential for TrkB (show NTRK2 Proteins) signaling and that disruption of Galphai1 or Galphai3 (show GNAI3 Proteins) function could contribute to depressive behaviors.
Stress from escapable electroshock (ES) was associated with up-regulation of brain-derived neurotrophic factor in amygdala as well as medial prefrontal cortex (mPFC). Stres from inescapable shock suppressed c-fos in mPFC (0 h) but induced more Arc (show NOL3 Proteins) in amygdala (2 h) in comparison with ES.
The present study revealed that long-term exercise increased BDNF expression in the motor cortex and facilitated a transfer of motor learning from aerobic exercise to postural coordination.
BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.
One of the modulators of TOR (show FRAP1 Proteins) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Proteins) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Proteins) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Proteins) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
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, brain-derived neurotrophic factor
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