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Human Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. BDNF (and NGF) levels in peripheral blood mononuclear cells were reduced in Neuropsychiatric Systemic Lupus Erythematosus patients compared to health controls.

2. study examines the link between methylation of the BDNF gene promoter region and patterns of neural activity that are associated with maternal response to stressful versus non-stressful child stimuli within a sample that includes mothers with interpersonal violence-related PTSD

3. Study investigated transcriptional regulation of Bipolar Disorder (BD) selected target genes by DNA methylation in peripheral blood mononuclear cells of patients with BD type I (BD-I) and type II (BD-II). A significantly positive correlation in promoter DNA methylation was observed in all subjects between PDYN and BDNF.

4. Genotyping of BDNF is not associated with P300 and N200 evoked potentials in patients with cognitive impairment.

5. A statistically significant interaction between BDNF Val66Met and job stress on depressive symptoms was found (p<0.05); individuals with Val/Val genotype showed a higher Self-rating Depression Scale (SDS) score than Met allele carriers only in the low-stress group, without significant differences in SDS score between the BDNF Val66Met subgroups in medium- or high-stress group.

6. Study revealed a significant relationship between serum mature BDNF and depressive mood in subacute stroke patients. In addition, serum levels of mature BDNF were not associated with stroke severity and cognitive function. Therefore, serum mature BDNF may be a biomarker of poststroke depression in subacute stroke patients.

7. Mesenchymal stem cells secretome is able to promote axonal outgrowth in central nervous system neurons and this effect is mediated by BDNF.

8. Exercise-induced reductions in some diabetes risk factors were associated with increases in serum BDNF in adolescents with obesity.

9. In chronic lymphocytic leukemia, higher serum BDNF levels were associated with a mutated immunoglobulin heavy chain variable gene, an early clinical stage, and a stable clinical course. In vitro, BDNF reduces the expression of CXCR4 in CLL cells and attenuates their migration.

10. BDNF levels were significantly decreased in active systemic lupus erythematous (SLE), when compared with inactive SLE, but not when compared with controls.

11. downregulation of the PGC-1alpha-FNDC5-BDNF signaling pathway in skeletal muscle contributes to resilience vs. susceptibility to chronic social defeat stress

12. the BDNF Val66Met polymorphism may impact posttraumatic stress disorder susceptibility differentially via enhanced threat sensitivity and hypothalamo-pituitary-adrenal axis dysregulation. Child abuse may moderate Val66Met's impact on threat reactivity.

13. A significant association of rs6265 AA+AGxrs1799964 CC+CT with schizophrenia was observed (OR=1.14, 95%CI: 1.02-1.27; P=.02). There were significant differences in the RBANS attention and total scores between the patients with rs6265A and rs1799964C alleles and those without these two alleles (P=.03 and P=.03 after Bonferroni correction, respectively).

14. The sample consisted of 181 suicide cases (47 early suicide cases, 134 late suicide cases) and 162 controls. Patients with the BDNF Met allele had a 1.42-fold increased risk of suicide when compared with the Val allele carrier. When a suicide case is stratified by occurrence time, patients with the Met/Val or Met/Met genotype had a 2.48-fold increased risk of committing suicide early than those with the Val/Val genotype.

15. Low brain derived neurotrophic factor may contribute to the pathogenesis of schizophrenia, but maybe not to its cognitive impairments.

16. In a 12-year longitudinal population-based sample of older adults (n = 2,218), we used growth curve modeling to investigate whether the benefits of physical activity on cognitive preservation differed by BDNF genotype and sex across multiple cognitive domains including processing speed, attention, working memory, and episodic verbal memory.

17. Mn-SOD V allele carries a worse outcome profile after stroke, relating to nitrosative stress, inflammatory, and apoptotic response and associated with a BDNF reduction.

18. while the BDNF Val66Met Megroup displayed significant SICI reduction in the bilateral M1 in response to motor training, short-interval intracortical inhibition (SICI) remained unchanged in the BDNF Val66Met group.

19. Our study provides evidence for the correlation between the BDNF variant rs6265 and emotional symptoms in the early phase after mild traumatic brain injury.

20. These results indicate that genetic variant Met66 decreased the serum BDNF levels in combination with self-reported risk-taking propensity among heroin users.

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.

2. An acute bout of exercise can recover BDNF-TrkB signalling in the prefrontal cortex of obese, glucose intolerant mice.

3. Results give strong evidence for a cell type-specific brain derived neurotrophin factor (BDNF), TrkB signaling in modulating neuronal architecture. Study propose that a BDNF-independent transactivation of TrkB receptor may be able to compensate the lack of BDNF signaling to modulate neuronal morphology in a cell type-specific manner.

4. These results suggest that psychological stress during gestation can induce long-term mood alterations in pregnant mice, which may correlate with changes in miR-206-3p and BDNF expression in the hippocampus, mPFC and amygdala.

5. structural analysis of binding of NGF, proNGF, and proBDNF to SorCS2

6. We report here on the incorporation of a BDNF mimetic sequence into a supramolecular peptide amphiphile filamentous nanostructure capable of activating the BDNF receptor TrkB and downstream signaling in primary cortical neurons in vitro.

7. Data (including data from studies in knockout mice) suggest that Bdnf is involved in neuroprotection and regulation of synaptic protein loss in cerebral cortex due to oxidative stress caused by high-fat diet.

8. Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis.

9. role in the maintenance of intestinal epithelial barrier function via anti-apoptotic properties

10. upregulation of PAI-1 may be a critical mechanism underlying insufficient neurotrophic support and increased neurodegeneration associated with AD. Thus, targeting BDNF maturation through pharmacological inhibition of PAI-1 might become a potential treatment for AD.

11. These observations suggest that GGA administration is a therapeutic candidate for depressive diseases by increasing hippocampal BDNF levels via HSP105 expression.

12. In a model of traumatic brain injury, transcranial ultrasound stimulation increases brain BDNF levels.

13. Results suggest that brain derived neurotrophic factor (BDNF) activation in the nucleus accumbens (NAc) may overcome memory and plasticity deficits linked to Actl6a protein (BAF53b) mutations.

14. Upregulating BDNF-AS inhibits osteogenesis, possibly through inverse regulation on BDNF and osteogenic signaling pathways

15. miR-322 promotes Tau phosphorylation via negatively controlling BDNF-TrkB receptor activation

16. BDNF preserves intestinal mucosal barrier function and alters gut microbiota in mice.

17. Results demonstrate that heterotrimeric Galphai1 and Galphai3 proteins are essential for TrkB signaling and that disruption of Galphai1 or Galphai3 function could contribute to depressive behaviors.

18. Stress from escapable electroshock (ES) was associated with up-regulation of brain-derived neurotrophic factor in amygdala as well as medial prefrontal cortex (mPFC). Stres from inescapable shock suppressed c-fos in mPFC (0 h) but induced more Arc in amygdala (2 h) in comparison with ES.

19. The present study revealed that long-term exercise increased BDNF expression in the motor cortex and facilitated a transfer of motor learning from aerobic exercise to postural coordination.

20. These results suggested that the effects of Valeriana fauriei (VF) extract on a model of fibromyalgia (FM)may be associated with its modulatory effects on the BDNF signaling pathway in the hippocampus and medial prefrontal cortex. In conclusion, the mechanism underlying the protective effects of VF as a therapeutic agent against FM may involve the BDNF signaling pathway

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]

2. BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.

3. One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.

4. These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals

5. BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

6. Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.

7. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

8. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

9. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.

10. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

11. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

3. activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.

4. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .

5. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

6. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.

7. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

8. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

9. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

10. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

11. PACAP stimulates the expression of BDNF transcript IV.

12. The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals

2. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

3. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

4. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.

2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) interaction partners

1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.

3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.