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Human BDNF Protein expressed in Wheat germ - ABIN1346621
Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012
Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062
Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014
Results show that Lnc RNA BDNF-AS inversely regulates the expression level of BDNF which modulates high-glucose induced apoptosis in human retinal pigment epithelial cells.
This study show a linear relationship between the BDNF Val66Met genotypes and plasma BDNF levels in Caucasian depressed patients.
Low BDNF expression is associated with Parkinson's disease.
Results suggest that serum brain-derived neurotrophic factor could play a role in modulating the cortical activity in response to visuo-tactile integration processes related to body image alteration in humans.
In a study of the genetic association between polymorphisms in the DAT1, SERT (show SLC6A4 Proteins), COMT (show COMT Proteins) and BDNF genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission
This review focus is on crosstalk among BDNF, Glucocorticoids (GCs (show GCLC Proteins)), and neurogenesis. It discusses recent studies concerning functional interaction between BDNF and GCs (show GCLC Proteins) in altered neurogenesis, and show an interesting effect of GCs (show GCLC Proteins): Alteration in intracellular transport of BDNF protein under GCs (show GCLC Proteins) stress. [review]
Met homozygotes participants showed significantly less muscle-specific (show EIF3K Proteins) corticospinal sensitivity during action observation, as well as reduced visuomotor associative learning, compared to Val homozygotes.
The results of the study may help to inform future health interventions that utilize physical activity as a means to improve cognitive development in children, adolescents, and adults. Additionally, the study may assist in determining whether the putative effects occur via modification of plasma IGF-1 (show IGF1 Proteins) or BDNF concentrations.
MicroRNA-382 inhibits cell proliferation and invasion of retinoblastoma by targeting BDNF-mediated PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.
No relation between the Val/Met polymorphism of the BDNF and the dynamics of the seizure threshold of electroconvulsive therapy in MDD.
These results suggested that the effects of Valeriana fauriei (VF) extract on a model of fibromyalgia (FM)may be associated with its modulatory effects on the BDNF signaling pathway in the hippocampus and medial prefrontal cortex. In conclusion, the mechanism underlying the protective effects of VF as a therapeutic agent against FM may involve the BDNF signaling pathway
findings demonstrate that not only is BDNF actively secreted by the transdifferentiated BDNF-mesenchymal stem cells, but also that it has the capacity to promote neurite sprouting and regeneration
Results indicate a modulatory effect of valproic acid on the Bbrain-derived neurotrophic factor (show NTF3 Proteins) levels in the ventral striatum. Study brings initial insights into the involvement of neurotrophic mechanisms in the ventral striatum in ethanol-induced addictive-like behavior.
significant increase of BDNF levels in the hippocampus and prefrontal cortex was observed in ethanol-treated mice receiving ginseng extract G115.
This findings consistently demonstrate that long-lasting nociceptive input activates VTA neurons and, via increased release of BDNF.
increased BDNF-TrkB (show NTRK2 Proteins) signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR (show CHRNA7 Proteins) plays a key role in depression
Findings suggest that carriers of the BDNF-Met allele may exhibit greater vulnerability to anxiety disorders and anorexia nervosa, contributed by increased excitability of pyramidal neurons, due to the combination of decreased GABAergic innervation of distal dendrites and BDNF-mediated suppression of perisomatic inhibitory inputs.
the ZnT3 (show Slc30a3 Proteins) null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 (show MMP9 Proteins) activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD (show GUSB Proteins).
There was a significant decrease in the BDNF protein expression along with an increase in the mRNA expression of CRH (show CRH Proteins), NR3C1 (show NR3C1 Proteins), CART, and NPY (show NPY Proteins) in intact females
Daily OMR (show ATP5A1 Proteins) testing during the critical period leads to general visual function improvements accompanied by increased DA and BDNF in the retina, with this process being requisitely mediated by TrkB (show NTRK2 Proteins) activation
One of the modulators of TOR (show FRAP1 Proteins) is brain-derived neurotrophic factor (BDNF), which activates the TOR (show FRAP1 Proteins) signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR (show FRAP1 Proteins) activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Proteins) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor