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Findings indicate that colony stimulating factor-1 receptor (CSF1R) signalling regulates inflammation in the central and peripheral nervous system in amyotrophic lateral sclerosis (ALS), suggesting therapeutic targeting of CSF1R in this disease.
Combining CSF1R inhibitor with a CXCR2 (show CXCR2 Proteins) antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
These findings reveal a novel and functionally important role for EHD1 (show EHD1 Proteins) in governing CSF-1R signalling via regulation of anterograde transport of CSF-1R to the macrophage cell surface.
Our findings thus demonstrate that microenvironmental alteration by CSF-1R blockade renders tumor cells more susceptible to receptor tyrosine kinase (show ERBB3 Proteins) inhibition in a preclinical glioblastoma model, which may have important translational relevance
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) and induction of D-type cyclins, cyclin D1 (show CCND1 Proteins) and D2.
CSF-1R role in the development of erythro-myeloid progenitor cells in the developing fetal liver
analysis of CSF1R-deficient mice establishes a distinct role of CSF1R in fetal B-lymphopoiesis.
study, therefore, provided insights into the sequence-structure-function relationships of the M-CSF/c-FMS interaction and of ligand/receptor tyrosine kinase (show ERBB3 Proteins) interactions in general.
this study shows that the iRhom2 (show RHBDF2 Proteins)/ADAM17 (show ADAM17 Proteins) pathway plays an important role in regulating CSF1R expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
this study shows that macrophage maturation is accompanied by colony-stimulating factor (show CSF2 Proteins) 1hypomethylation, and illustrates for the first time the ability of protein kinase A to increase Csf1r DNA methylation (show HELLS Proteins)
Adult-onset Mendelian leukodystrophy genes are not common factors implicated in Alzheimer's disease, but there is a potential pathogenic link between NOTCH3 (show NOTCH3 Proteins), CSF1R, and sporadic late-onset Alzheimer's disease.
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.(S39-S41) is a subtype of dominantly inherited leukoencephalopathy caused by CSF1R mutations.
Concerning pigmented villonodular synovitis , clinical trials assessing CSF-1R inhibitors have revealed promising initial outcomes. Blocking CSF-1/CSF-1R signaling represents a promising immunotherapy approach and several new potential combination therapies for future clinical testing.
this is the first study to demonstrate CSF1R genetic variant regulates the CSF-1R signaling and sensitivity to CSF-1R inhibitors.
Hypoxia promotes glioma-associated macrophage infiltration via periostin (show POSTN Proteins) and subsequent M2 polarization by upregulating TGF-beta (show TGFB1 Proteins) and M-CSFR.
CSF-1R is a novel therapeutic target.
The phenotype of adult-onset leukoencephalopathy axonal spheroids and pigmented glia caused by CSF1R mutations is affected by sex
Results suggest that TP63 (show TP63 Proteins) rs7631358 G > A and CSF1R rs10079250 A > G may affect the risk and prognosis of lung cancer in never-smoking females.
study, therefore, provided insights into the sequence-structure-function relationships of the M-CSF (show CSF1 Proteins)/c-FMS interaction and of ligand/receptor tyrosine kinase (show RET Proteins) interactions in general.
findings suggest that expression of wild-type CSF1R in some cells, whether achieved by mosaicism or chimerism, may confer benefit in hereditary diffuse leukoencephalopathy with axonal spheroids.
Data suggest that fms is not required for establishing a population of precursor cells during embryogenesis but is required for recruiting pigment cell precursors to xanthophore fates, with concomitant effects on melanophore organization.
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
, macrophage colony-stimulating factor 1 receptor
, proto-oncogene c-Fms
, proto-oncogene fms
, CD115 antigen
, FMS proto-oncogene
, McDonough feline sarcoma viral (v-fms) oncogene homolog
, macrophage colony stimulating factor I receptor
, colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog
, platelet-derived growth factor receptor, beta polypeptide
, protein-tyrosine kinase
, macrophage colony-stimulating factor receptor
, csf1r protein
, colony stimulating factor 1 receptor
, macrophage colony-stimulating factor 1 receptor-like
, fms proto-oncogene
, fms proto-oncogene homolog
, proto-oncogene c-Fms homolog
, proto-oncogene fms homolog