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anti-Human FGF2 Antibodies:
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Guinea Pig Polyclonal FGF2 Primary Antibody for IF (cc), IF (p) - ABIN726425
Pan, Wang, Xiang, Shao: Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation. in The Journal of biological chemistry 2011
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Human Polyclonal FGF2 Primary Antibody for ELISA, IHC (p) - ABIN3042812
Wang, Wang, Yao, Wu, Tang, Gu, Li: The fibroblast growth factor-2 arrests Mycobacterium avium sp. paratuberculosis growth and immunomodulates host response in macrophages. in Tuberculosis (Edinburgh, Scotland) 2015
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Human Polyclonal FGF2 Primary Antibody for WB - ABIN3042390
Zhou, Ma, Si, Li, Xu, Tu, Wang: MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. in Cancer letters 2013
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Human Monoclonal FGF2 Primary Antibody for IHC, ELISA - ABIN969137
Romanov, James, Sherrington, Pettitt: Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia. in Oncogene 2005
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Human Polyclonal FGF2 Primary Antibody for ELISA, IHC - ABIN6254910
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. in Oncotarget 2018
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Human Monoclonal FGF2 Primary Antibody for IHC (fro), ELISA - ABIN2473612
Kalsheker, Watkins, Hill, Morgan, Stockley, Fick: Independent mutations in the flanking sequence of the alpha-1-antitrypsin gene are associated with chronic obstructive airways disease. in Disease markers 1991
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Cow (Bovine) Polyclonal FGF2 Primary Antibody for IHC (p), IHC - ABIN269699
de Ruijter-Villani, van Boxtel, Stout: Fibroblast growth factor-2 expression in the preimplantation equine conceptus and endometrium of pregnant and cyclic mares. in Theriogenology 2013
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Human Monoclonal FGF2 Primary Antibody for IHC, ELISA - ABIN966137
Kim, Shin, Choi, Kim, Ahn, Lee, Park, Kim, Mok, Nam: A preliminary results of a randomized trial comparing monthly 5-flourouracil and cisplatin to weekly cisplatin alone combined with concurrent radiotherapy for locally advanced cervical cancer. in Cancer research and treatment : official journal of Korean Cancer Association 2009
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Human Monoclonal FGF2 Primary Antibody for ELISA - ABIN5578085
Akl, Nagpal, Ayoub, Tai, Prabhu, Capac, Gliksman, Goy, Suh: Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies. in Oncotarget 2016
Human Polyclonal FGF2 Primary Antibody for IHC, WB - ABIN6714685
Su, Rao, Guo, Li, Ahmed, Ni, Grossmann, Zhao: In ovo leptin administration inhibits chorioallantoic membrane angiogenesis in female chicken embryos through the STAT3-mediated vascular endothelial growth factor (VEGF) pathway. in Domestic animal endocrinology 2012
Mechanistic functional studies revealed that linc-ROR promoted HASMC proliferation and migration via regulating miR-195-5p/FGF2 axis.
These findings shed new light on the role elicited by estrogens through GPER in the activation of the FGF2/FGFR1 signaling.
these results highlight a novel mechanism underlying hi-FGF2-induced, mitochondria-driven cell death involving the direct interaction between hi-FGF2 and C1QBP and the upregulation of C1QBP expression.
In the lung, FGF2 is antifibrotic in part through decreased collagen expression and fibroblast to myofibroblast differentiation.
we show a mechanism whereby FGF2 promotes migration of MSCs by modifying N-glycans. This work may help improve delivery of MSCs in therapeutic settings.
The basic fibroblast growth factor 2 (FGF2) level was markedly increased in H1N1 virus-infected humans and mice. FGF2, which is predominately derived from epithelial cells, recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFkappaB signaling pathway.
FGF2/FGFR1 signaling is a potential mechanistic link in visceral adipose tissue-stimulated transformation of breast epithelial cells
circulating levels of FGF2 significantly decreased after arterial embolization in patients with bone metastases
Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2, similar to the human corneal endothelium ex vivo.
We explored the mechanisms of FGF2 regulation of neuronal gene expression and synaptic function.
Serum levels of bFGF in patients with ovarian cancer are significantly higher than in patients with a border-line ovarian tumor, with benign ovarian cyst and in women with normal ovarian tissue regardless of age of patients.
Kaplan-Meier analysis showed that Hepatitis B Virus-associated Hepatocellular Carcinoma patients with the FGF2 rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0.016) and that FGF2 rs308379 A allele carriers had shorter overall survival than patients with the TT genotype (p=0.020).
our findings suggest that increased FGF-2 expression and increased FGFR-1 expression are associated with high-grade oral epithelial dysplasia, and are correlated with the presence of metastasis and adverse outcomes in oral tongue squamous cell carcinoma patients.
miR-203 decreased the proliferation, invasion, and ECM production of keloid fibroblasts by repressing EGR1 and FGF2 expression.
It. is a multifunctional cytokine expressed in several tissues and involved in a wide variety of biologic activities.
Taken together, this study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.
the Blood-brain barrier protection effect of bFGF is at least partially through rescuing the oxygen-glucose deprivation and reoxygenation-induced downregulation of sphingosine-1-phosphate receptor 1 (S1PR1) protein.
baseline level of bFGF was necessary for the prediction of combined treatment in patients with NSCLC stage III. The threshold value bFGF>10,2 ng/ml allowed predicting a good effect from chemotherapy with a sensitivity of 71,4% and specificity of 80,6%, while the sensitivity of VEGF in terms of forecasting bicycles reached 42,9 %.
miR-148b-3p attenuates renal carcinoma cell growth, the invasion and tube formation of endothelial cell potentially via regulating FGF2-FGFR2 signaling pathway.
Data suggest that SNAI1 is a key regulator of FGF2-dependent mesenchymal transition in corneal endothelium, with ZEB1 regulating type I collagen expression and CDK2 regulating cell proliferation. (SNAI1 = snail family transcriptional repressor-1; FGF2 = fibroblast growth factor-2; ZEB1 = zinc finger E-box binding homeobox-1 protein; CDK2 = cyclin dependent kinase-2)
proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo.
fter injury, Sca-1(+) cells in the retina reduced host cellular apoptosis, which was associated with higher expression of fibroblast growth factor 2 (FGF2) in the Sca-1(+) chimaeras. Young Sca-1(+) cells repopulated the stem cells in the aged retina and diminished cellular apoptosis after acute I/R injury through FGF2 and Akt signalling pathways.
lack of FGF-2 leads to dysregulated sperm production and altered sperm morphology and function.
These results suggest that FGF2 contributes to induction of differentiation rather than maintenance of undifferentiated spermatogonia, indicating reconsideration of the role of FGF2 in the germline niche.
Enriched salivary epithelial clusters that were grown in laminin-enriched basement membrane extract or laminin-111 together with exogenous FGF2, but not with EGF, underwent morphogenesis to form organoids that displayed robust expression of AQP5 in terminal buds
The results of this study highlight a novel mechanism by which FGF-2 can regulate osteoblast differentiation and osteocyte formation. Specifically, the data suggests that FGF-2 promotes osteocytogenesis through increased E11 expression and further studies will identify if this regulatory pathway is essential for bone development and maintenance in health and disease.
In the TGF-beta type II receptor (Tgfbr2) knockout (KO) model, basic fibroblast growth factor (bFGF) was identified as the mediator of the metastasis-promoting effect from osteoblasts.
expressed in tissues of the female reproductive tract; affects sperm motility and acrosomal exocytosis
present study highlights the central role for FGF-2 in the progression and maintenance of newly acquired blood and lymphatic vessels in the cornea of HSV-1-infected mice in the absence of infectious virions
NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.
Fibroblast growth factor (FGF1 and FGF2), but not vascular endothelial growth factor (VEGF) rescued Psen1-/- cells from serum starvation induced apoptosis.In the absence of serum, FGF2 immunoreactivity was distributed diffusely in cytoplasmic and nuclear vesicles of wt and Psen1-/- cells, as levels of FGF2 in nuclear and cytosolic fractions were not significantly different.
Knockout of the 18-kDa FGF-2 isoform significantly attenuated atherogenesis, reduced aortic plaques, reduced macrophage infiltration and suppressed oxidative stress in mice fed with a high fat diet at all-time points.
Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis.
BMP4 promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling in the presence of FGF-2.
FGF2 signaling can regulate osteoblastic niche cells to support HSC homeostasis in response to bone marrow damage
Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signaling.
altered glycosaminoglycans (GAG) distribution in mucopolysaccharidoses I (MPS I) chondrocytes, and altered GAG, FGF2 and Indian hedgehog distribution in growth plates from MPS I mice, is reported.
Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling.
These results suggest that bFGF activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221.
activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
Data suggest THBS1 (thrombospondin-1) expression predominates in luteal endothelial cells; THBS2 expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1/THBS2 but up-regulate expression of FGF2.
Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA during these specific windows.
FGF2 was crucial for luteal endothelial network formation.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
FGF2 and FGF10 regulate migratory activity of ovine trophoblast cells through MAPK-dependent pathways.
investigation of signaling mechanisms used by FGF2 to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through protein kinase C-delta
Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
Immunohistochemistry in rectus abdominis muscle from foetuses at 180 and 260 days post-conception
bFGF is oxidized by lysyl oxidase
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1) released by endothelial cells
in luteolysis FGF-2 may participate in the suppression of cytokine-induced iNOS mRNA expression and in the prevention of an inflammatory reaction in the surrounding tissues.
FGF2 stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK)-dependent pathway
we compare ACTH and fibroblast growth factor 2 (FGF2) antagonistic effects on the cell cycle in the Y1 cell line, a functional lineage of mouse adreno-cortical tumor cells
Excessive stress on cartilage inhibits the production of basic fibroblast growth factor (bFGF) in a nitric oxide-independent manner, and interleukin-4 plays an important role in the reduction of bFGF.
pleiotropic effect of FGF2 on the control of spermatogenesis in a paracrine and/or autocrine manner
FGF-2 stimulates IFNT expression and plays an active role in regulating the establishment and maintenance of pregnancy in ruminants
there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region
FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.
Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway.
The overlapping relationships of 3'UTR ends between NUDT6 and FGF-2 genes, were analyzed.
FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.
By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.
qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.
FGF2 activates FGFR which then represses the fibroblast activation of valvular interstitial cells.
FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1)-mediated myofibroblast activation
upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
The rabbit bFGF gene was successfully introduced into the bone marrow stromal cells cultured in vitro by lentiviral vector, and the target gene was stably expressed. And the expression of bFGF can promote the proliferation and osteogenic differentiation of bone marrow stromal cells .
High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-beta may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis.
Continuous passive motion can promote b-FGF expression to enhance type III collagen synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits.
Results uncover a novel Sdc2-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
basic fibroblast growth factor bFGF
, fibroblast growth factor 2
, heparin-binding growth factor 2
, basic fibroblast growth factor
, Basic fibroblast growth factor
, Heparin-binding growth factor 2