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anti-Human FGF2 Antibodies:
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Guinea Pig Polyclonal FGF2 Primary Antibody for IF (cc), IF (p) - ABIN726425
Pan, Wang, Xiang, Shao: Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation. in The Journal of biological chemistry 2011
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Human Polyclonal FGF2 Primary Antibody for ELISA, IHC (p) - ABIN3042812
Wang, Wang, Yao, Wu, Tang, Gu, Li: The fibroblast growth factor-2 arrests Mycobacterium avium sp. paratuberculosis growth and immunomodulates host response in macrophages. in Tuberculosis (Edinburgh, Scotland) 2015
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Human Polyclonal FGF2 Primary Antibody for WB - ABIN3042390
Zhou, Ma, Si, Li, Xu, Tu, Wang: MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. in Cancer letters 2013
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Human Monoclonal FGF2 Primary Antibody for IHC, ELISA - ABIN969137
Romanov, James, Sherrington, Pettitt: Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia. in Oncogene 2005
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Human Polyclonal FGF2 Primary Antibody for ELISA, IHC - ABIN6254910
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. in Oncotarget 2018
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Human Monoclonal FGF2 Primary Antibody for IHC, ELISA - ABIN966137
Kim, Shin, Choi, Kim, Ahn, Lee, Park, Kim, Mok, Nam: A preliminary results of a randomized trial comparing monthly 5-flourouracil and cisplatin to weekly cisplatin alone combined with concurrent radiotherapy for locally advanced cervical cancer. in Cancer research and treatment : official journal of Korean Cancer Association 2009
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Human Monoclonal FGF2 Primary Antibody for IHC (fro), ELISA - ABIN2473612
Kalsheker, Watkins, Hill, Morgan, Stockley, Fick: Independent mutations in the flanking sequence of the alpha-1-antitrypsin gene are associated with chronic obstructive airways disease. in Disease markers 1991
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Cow (Bovine) Polyclonal FGF2 Primary Antibody for IHC (p), IHC - ABIN269699
de Ruijter-Villani, van Boxtel, Stout: Fibroblast growth factor-2 expression in the preimplantation equine conceptus and endometrium of pregnant and cyclic mares. in Theriogenology 2013
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Human Polyclonal FGF2 Primary Antibody for IHC (fro), WB - ABIN537890
Liu, Zhang, Xiao, Lu: Critical Role of IP-10 on Reducing Experimental Corneal Neovascularization. in Current eye research 2014
Human Monoclonal FGF2 Primary Antibody for IF, IHC - ABIN2721042
Pickard, Adams, Barraud, Chari: Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes. in Journal of functional biomaterials 2015
miR-148b-3p attenuates renal carcinoma cell growth, the invasion and tube formation of endothelial cell potentially via regulating FGF2-FGFR2 signaling pathway.
Data suggest that SNAI1 is a key regulator of FGF2-dependent mesenchymal transition in corneal endothelium, with ZEB1 regulating type I collagen expression and CDK2 regulating cell proliferation. (SNAI1 = snail family transcriptional repressor-1; FGF2 = fibroblast growth factor-2; ZEB1 = zinc finger E-box binding homeobox-1 protein; CDK2 = cyclin dependent kinase-2)
The Novel Short Isoform of Securin Stimulates the Expression of Cyclin D3 and Angiogenesis Factors VEGFA and FGF2, but Does Not Affect the Expression of MYC Transcription Factor
miR-155 and FGF2 is associated with esophageal cancer progression. miR-155 in Tumor-associated macrophages suppressed ECA109cell proliferation, migration and invasion, as well as reduction in angiogenesis. miR-155-reduced cell growth, migration and invasion of ECA109cells is associated with FGF2 suppression.
the dual warhead-FGF2 conjugate may overcome the potential acquired resistance of FGFR1-overproducing cancer cells towards single cytotoxic drugs.
widely stained in sclerosing stromal tumours of the ovary
FGF2 initiates CYGB transcription via the JNK pathway.
A strong stromal FGF-2 expression was associated with a significantly higher clinical stage and higher biochemical recurrence rate. Patients with strong stromal FGF-2 expression also had a significantly worse biochemical recurrence-free survival.
levels of the angiogenesis mediators endoglin, HB-EGF, BMP-9 and FGF-2 in patients with severe sepsis and septic shock
Our results suggest photodynamic therapy is effective in increasing the expression of bFGF gene, an important factor in periodontal tissue regeneration and could indicate periodontal tissue regeneration
High FGF2 expression is associated with gastric cancer.
Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCalpha signalling and cross-talk with TGF-beta1.
evaluation of the presence and localization of FGF2 in human sperm cells, and determination of FGF2 levels in semen samples and its relationship with conventional semen parameters
We have presented evidence that FGF2 promotes myofibroblast apoptosis in vivo, antagonizes pro-fibrotic TGF-beta signaling, inhibits fibroblast activation and prevents transdifferentiation of non-fibroblasts into myofibroblasts, and promotes a less fibrotic gene expression paradigm [Review]
These results demonstrate that FGF-TGFbeta signaling antagonism is the primary regulator of the smooth muscle cell phenotype switch.
Results describe a novel role of FGF2 as a modulator of osteoblast and mesenchymal stromal cell function, and provide evidence for involvement of FGF2 in leukemia pathogenesis and chemo-resistance.
Under specific experimental conditions, secretion of IL-1beta and FGF2 is triggered by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]-dependent formation of pores across the plasma membrane.
HDAC1 depletion activates cardiac mesenchymal stromal cells proangiogenic paracrine signaling in a basic fibroblast growth factor-dependent manner.
The results suggest that FGF2/rs1048201, FGF5/rs3733336 and FGF9/rs546782 are associated with the risk of non-syndromic orofacial cleft and that these miRNA-FGF interactions may affect non-syndromic orofacial cleft development.
TEC is yet another regulator of FGF2-mediated Human pluripotent stem cells pluripotency and differentiation.
In the TGF-beta type II receptor (Tgfbr2) knockout (KO) model, basic fibroblast growth factor (bFGF) was identified as the mediator of the metastasis-promoting effect from osteoblasts.
expressed in tissues of the female reproductive tract; affects sperm motility and acrosomal exocytosis
present study highlights the central role for FGF-2 in the progression and maintenance of newly acquired blood and lymphatic vessels in the cornea of HSV-1-infected mice in the absence of infectious virions
NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.
Fibroblast growth factor (FGF1 and FGF2), but not vascular endothelial growth factor (VEGF) rescued Psen1-/- cells from serum starvation induced apoptosis.In the absence of serum, FGF2 immunoreactivity was distributed diffusely in cytoplasmic and nuclear vesicles of wt and Psen1-/- cells, as levels of FGF2 in nuclear and cytosolic fractions were not significantly different.
Knockout of the 18-kDa FGF-2 isoform significantly attenuated atherogenesis, reduced aortic plaques, reduced macrophage infiltration and suppressed oxidative stress in mice fed with a high fat diet at all-time points.
Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis.
BMP4 promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4-Smad1/5/8-Id1 signaling in the presence of FGF-2.
FGF2 signaling can regulate osteoblastic niche cells to support HSC homeostasis in response to bone marrow damage
Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signaling.
altered glycosaminoglycans (GAG) distribution in mucopolysaccharidoses I (MPS I) chondrocytes, and altered GAG, FGF2 and Indian hedgehog distribution in growth plates from MPS I mice, is reported.
Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling.
tissue engineered periosteum can deliver FGF-2, TGF-beta1, and ASCs to a mouse critical-sized femur defect and further optimization may yield improved bone allograft healing.
Thus, FGF-2 levels in hESCs culture systems can be manipulated to generate cells with longer telomere which would be advantageous in the applications of hESCs in regenerative medicine.
Low FGF2 expression is associated with cardiac ischemia and systolic dysfunction.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB.
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform
data suggest that FGF2 levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2, and FGFR3.
The differentiation of ERF-overexpressing trophoblast stem cell lines also suggests that ERF may have an FGF2-independent effect during the commitment towards syncytiotrophoblasts.
Novel VF-Trap fusion protein on blockage of VEGF and FGF-2 activity to prevent angiogenesis.
These results suggest that bFGF activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
Data suggest THBS1 (thrombospondin-1) expression predominates in luteal endothelial cells; THBS2 expression predominates in luteinized granulosa cells. Luteinizing signals down-regulate expression of THBS1/THBS2 but up-regulate expression of FGF2.
Mixed populations of luteal cells were treated with SU1498 (VEGF receptor 2 inhibitor) or SU5402 (FGF receptor 1 inhibitor) or control on days 0-3, 3-6 or 6-9 to determine the role of FGF2 and VEGFA during these specific windows.
FGF2 was crucial for luteal endothelial network formation.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
FGF2 and FGF10 regulate migratory activity of ovine trophoblast cells through MAPK-dependent pathways.
investigation of signaling mechanisms used by FGF2 to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through protein kinase C-delta
Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
Immunohistochemistry in rectus abdominis muscle from foetuses at 180 and 260 days post-conception
bFGF is oxidized by lysyl oxidase
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1) released by endothelial cells
in luteolysis FGF-2 may participate in the suppression of cytokine-induced iNOS mRNA expression and in the prevention of an inflammatory reaction in the surrounding tissues.
FGF2 stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK)-dependent pathway
we compare ACTH and fibroblast growth factor 2 (FGF2) antagonistic effects on the cell cycle in the Y1 cell line, a functional lineage of mouse adreno-cortical tumor cells
Excessive stress on cartilage inhibits the production of basic fibroblast growth factor (bFGF) in a nitric oxide-independent manner, and interleukin-4 plays an important role in the reduction of bFGF.
pleiotropic effect of FGF2 on the control of spermatogenesis in a paracrine and/or autocrine manner
FGF-2 stimulates IFNT expression and plays an active role in regulating the establishment and maintenance of pregnancy in ruminants
there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
FOXO1-suppressed miR-424 regulates both the proliferation and osteogenic differentiation of mesenchymal stem cells via targeting FGF2.
Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway.
The overlapping relationships of 3'UTR ends between NUDT6 and FGF-2 genes, were analyzed.
FGF2 in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.
By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 from endothelial cells.
qPCR analysis demonstrated an increase in FGF-2 mRNA levels beginning on day 75 and on day 114 of pregnancy.
FGF2 activates FGFR which then represses the fibroblast activation of valvular interstitial cells.
FGF2 effectively blocks transforming growth factor-beta1 (TGF-beta1)-mediated myofibroblast activation
upregulation of TGFalpha or FGF2 expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-beta may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis.
Continuous passive motion can promote b-FGF expression to enhance type III collagen synthesis at the tendon-bone interface in early stage of tendon-bone repair following acute rupture of supraspinatus tendon in rabbits.
Results uncover a novel Sdc2-Tbx16-Fgf2 pathway that regulates epithelial cell morphogenesis.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
basic fibroblast growth factor bFGF
, fibroblast growth factor 2
, heparin-binding growth factor 2
, basic fibroblast growth factor
, Basic fibroblast growth factor
, Heparin-binding growth factor 2