FGF2 antibody

Catalog No. ABIN969137

There are 3+ publications for this product available. The Mouse Monoclonal anti-FGF2 antibody is suitable to detect FGF2 in samples from Human. It has been validated for ELISA and IHC.

Quick Overview for FGF2 antibody (ABIN969137)

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGF2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 2H5G2C11

Product Details anti-FGF2 Antibody

Purpose: FGF2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of FGF2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FGF2 antibody (ABIN969137)

Kim, Shin, Choi, Kim, Ahn, Lee, Park, Kim, Mok, Nam: "A preliminary results of a randomized trial comparing monthly 5-flourouracil and cisplatin to weekly cisplatin alone combined with concurrent radiotherapy for locally advanced cervical cancer." in: Cancer research and treatment : official journal of Korean Cancer Association, Vol. 37, Issue 1, pp. 37-43, (2009) (PubMed).

Romanov, James, Sherrington, Pettitt: "Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia." in: Oncogene, Vol. 24, Issue 45, pp. 6855-60, (2005) (PubMed).

Webber, Chen, Hehr, Johnston, McFarlane: "Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance." in: Molecular and cellular neurosciences, Vol. 30, Issue 1, pp. 37-47, (2005) (PubMed).

Target Details for FGF2

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Alternative Name: FGF2

Background: FGF2 is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of anguogenesis. Due to its basic pH , the factor is named FGF-2 (basic FGF, bFGF).Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Gene ID: 2247

UniProt: P09038

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins