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FGF2 antibody (Middle Region)

FGF2 Reactivity: Human, Mouse, Rat, Rabbit, Dog, Sheep, Cow, Guinea Pig, Zebrafish (Danio rerio), Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777106
  • Target See all FGF2 Antibodies
    FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))
    Binding Specificity
    • 39
    • 16
    • 12
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 127
    • 56
    • 53
    • 20
    • 16
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Dog, Sheep, Cow, Guinea Pig, Zebrafish (Danio rerio), Horse
    Host
    • 115
    • 31
    • 3
    • 2
    Rabbit
    Clonality
    • 111
    • 40
    Polyclonal
    Conjugate
    • 71
    • 15
    • 12
    • 9
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This FGF2 antibody is un-conjugated
    Application
    • 106
    • 62
    • 50
    • 34
    • 26
    • 26
    • 20
    • 17
    • 16
    • 16
    • 11
    • 9
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    RLESNNYNTY RSRKYTSWYV ALKRTGQYKL GSKTGPGQKA ILFLPMSAKS
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against FGF2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human FGF2
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    Discover our top product FGF2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 288 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))
    Alternative Name
    FGF2 (FGF2 Products)
    Synonyms
    BFGF antibody, FGF-2 antibody, FGFB antibody, HBGF-2 antibody, Fgf-2 antibody, Fgfb antibody, bFGF antibody, fibroblast growth factor 2 antibody, fibroblast growth factor 2 (basic) antibody, FGF2 antibody, Fgf2 antibody, fgf2 antibody
    Background
    The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: BFGF, FGFB, HBGF-2
    Protein Interaction Partner: TUBG1, HMT1, PRMT1, CRYAB, THBS1, UBC, API5, CEP57, FGFRL1, FGFBP1, CXCL13, RPL6, RPS19, PTX3, NRP1, GPC4, RPS6KA3, GPC3, VTN, SDC3, SDC1, PF4, HSPG2, SDC2, FGFR1, FGFR4, FGFR3, FGF2, CSNK2A2, CSNK2B, CSNK2A1, CD44, SDC4,
    Protein Size: 288
    Molecular Weight
    31 kDa
    Gene ID
    2247
    NCBI Accession
    NM_002006, NP_001997
    UniProt
    P09038
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins
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