Browse our anti-FGF4 (FGF4) Antibodies

Human Fibroblast Growth Factor 4 (FGF4) interaction partners

1. FGF4 amplification was an independent prognostic factor in esophageal squamous cell carcinoma patients

2. our study demonstrated that FGFR4 rs2011077 and rs1966265 are associated with the progression of cervical normal tissues to precancerous lesions in Taiwanese women. Moreover, rs351855 (Gly388Arg) is the only FGFR4 genetic polymorphism that is associated with patient survival.

3. Thus, we conclude that the oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Therapeutically, HBXIP may serve as a novel target in breast cancer.

4. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.

5. Data show that the interaction between Artd1 and Sox2 is crucial for the first steps of the reprogramming process and that early expression of Fgf4 is an essential component for the successful generation of iPSCs.

6. A de novo 290 kb interstitial duplication of chromosome 11q13.3 including the FGF3 and FGF4 genes.

7. Myoblasts which overexpress FGF-4 exhibit significant changes in cell cycle and pro-angiogenic potential with only slight differences in the expression of the myogenic genes.

8. In vivo stimulation of BT-474 cell growth by progesterone is associated with up-regulation of FGF4 which may promote tumor growth and maintenance.

9. knockdown of FGFR4 expression led to decreased proliferation and an increased rate of apoptosis in the MKN45 and SGC7901 GC cell lines

10. activation of human HST-1 gene in transgenic mice induces spermatogenesis and prevents adriamycin-induced testicular toxicity

11. possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts

12. Differential effects of FGF4, EGF and TGFB1 on functional development of stromal layers (progenitor cell-outputs) in acute myeloid leukemia

13. results show that Hensen's node and FGFs induce ectopic expression of cardiac lineage markers, and that FGF and TGFbeta family members can modulate early development of the heart

14. FGF4 is upregulated by the OCT3 transcription factor in breast cancer cells.

15. HST-1 protects male germ cells from apoptosis under heat-stress condition in a mouse model.

16. Both myeov and hst (fgf4) are normally situated approximately 475-kb apart at band 11q13, a region that is frequently amplified and overexpressed in various tumours.

17. FGF-4 increases the rate at which MSC proliferate and has no significant effect on MSC pluripotency

18. These results suggest a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development.

19. Implantation of human FGF4-soaked beads is sufficient to restore expression of G1- and S-phase cell-cycle genes and S-phase progression in zebrafish sonic hedgehog (Shh) mutant fin buds.

20. The combined action of retinoic acid and FGF4 results in induction of PDX1+ foregut endoderm.

Mouse (Murine) Fibroblast Growth Factor 4 (FGF4) interaction partners

1. results demonstrate the mechanism for the maintenance of the undifferentiated state of embryonic stem cells via the inhibition of the FGF4-PKCzeta-MEK-ERK1/2 pathway by O-GlcNAcylation on PKCzeta.

2. The correlation in expression of FGF4 with specific stages of tooth morphogenesis support its regulatory function.

3. We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 and Fgf8 signaling to orient PCP.

4. Klf5 suppresses Fgf4-Fgfr-ERK signalling, thus preventing precocious activation of the primitive endoderm specification programme

5. the paternal genome facilitates the proliferation of trophoblast cells without FGF4 signaling

6. There was intense Fgf4 expression observed in the PEK of the cap-stage tooth germ at E14. At E15, Fgf4 became sparse in the epithelium except for the PEK. Fgf4 was exclusively expressed in the apical end of the labial epithelium during E16-18

7. With efficient chimera-forming capability using a medium containing fibroblast growth factor (FGF)-4.

8. Taken together, our results demonstrated that mating behaviours influenced embryonic development in vitro by decreasing FGF4 expression.

9. the amount of FGF4 is limited and regulates PE/EPI proportions in the mouse embryo.

10. The role of Fgf4 in response to apoptosis and genotoxic stress is discussed.

11. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse

12. FGF4 is required to maintain a population of progenitor cells in the epiblast that generates mesoderm and contributes to the stem cell population that is incorporated in the tailbud and required for axial elongation of the mouse embryo after gastrulation.

13. This study uncovers an important role of HDAC1 and histone modifications in the repression of Fgf4 and perhaps other pluripotency genes during embryonic stem cell differentiation.

14. study provides genetic evidence that FGFs are the wavefront signal and identifies the data show that FGF action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM progenitor tissue

15. Cells ceased proliferation and differentiated when FGF4, heparin, and rat embryonic fibroblasts conditioned medium were removed.

16. KDM7A is a dual-specificity histone demethylase that regulates neural differentiation through FGF4.

17. Trophoblast stem cell FRS2alpha mediates activation of the ERK pathway to enhance Cdx2 expression in response to FGF4. Cdx2 in turn binds to an FGF4-responsive enhancer element of the promoter region of Bmp4, leading to production and secretion of Bmp4.

18. FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER

19. p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene

20. Fgf4 is expressed in early inner ear development.

Cow (Bovine) Fibroblast Growth Factor 4 (FGF4) interaction partners

1. Present study provides a simple method for the production of a bioactive bovine FGF4 derivative in E.coli utilizing its structural gene.

2. this is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds

3. Fgf4 exhibited significant hypermethylation in sperm compared with that in oocytes