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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398
Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011
Show all 4 Pubmed References
Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN803884
de Waal, Leal, García-López, Liarte, de Jonge, Hinfray, Brion, Schulz, Bogerd: Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis. in The Journal of endocrinology 2009
Show all 2 Pubmed References
Human IGF1 Protein expressed in - ABIN1111672
Devi, Dixit: Clinical Evaluation of Insulin like Growth Factor-I and Vascular Endothelial Growth Factor with Alloplastic Bone Graft Material in the Management of Human Two Wall Intra-Osseous Defects. in Journal of clinical and diagnostic research : JCDR 2016
Human IGF1 Protein expressed in Insect cells (Sf9) - ABIN935729
Ablonczy, Crosson: VEGF modulation of retinal pigment epithelium resistance. in Experimental eye research 2007
These results suggest that the classical metabolic PI3K pathway and not the canonical proliferation ERK pathway is involved in the insulin/insulin-like growth factor-1-induced increase in crypt proliferation in obese humans, which may contribute to abnormal tissue renewal and function.
single nucleotide polymorphisms of IGF-1 axis genes appear to play minor roles in the risk for development of central precocious puberty in girls.
IGF-I has an anti-apoptotic protective effect in zebrafish embryos with tbx5 deficiency.
Mean IGF-1 levels were significantly lower in the HD group.
Insulin like growth factor-I and its receptor are upregulated in children with nonalcoholic fatty liver disease. These findings give a new hint for the potential therapeutic use of insulin like growth factor-I in pediatric nonalcoholic fatty liver disease complicated by liver fibrosis.
The successful replication in two independent samples indicated that IGF1 is associated with triglyceride levels in subjects with a family history of hypertension in Taiwan.
Aging is associated with dysregulated and exaggerated IGF-1 signaling, which may represent an incomplete compensatory cellular response to overcome age-related anabolic resistance.
higher levels of IGF-1 appeared to confer some protection against hearing impairment in some older adults.
Studied insulin like growth factor 1 levels in European patients with hepatocellular carcinoma (HCC); found serum IGF-1 levels to be significantly lower in patients with HCC in cirrhosis compared with non-cirrhotic HCC.
However, the analysis stratified by ethnicity revealed that rs1520220 significantly increased cancer susceptibility in Asian populations
In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk.
The serum level of IGFBP-3 was down-regulated and the IGF-1 activity was up-regulated by 4-week moderate aerobic exercise plus diet control in female obese youths and adolescents.
SNX6 knockdown resulted in a dramatic diminution of IGF1-mediated ERK1/2 phosphorylation, but did not affect IGF1R internalization.
We found that elevated production of insulin-like growth factor 1 by polyploid ASCs rendered them more potent in tumor growth promotion in vitro.
No up-regulation of Wnt10A and IGF-1 mRNA was observed with 1,550-nm Er:Glass fractional laser treatment of androgenetic alopecia.
Significant negative or positive correlations were observed between IGF-1 concentrations and impairments on several EDI-2 subscales (drive for thinness, body dissatisfaction, interoceptive awareness, sense of ineffectiveness, interpersonal distrust, maturity fear) and on SCL-90 subitems (depression, hostility, obsessivity compulsivity, anxiety), suggesting a possible hormonal modulatory effect on specific aspects of eatin
This article reviews the tumor-specific molecular signatures of IGF-1-mediated epithelial-mesenchymal transition in breast, lung, and gastric cancers. [review]
Results provide evidence for the role of IGF-I: matrix protein interactions in cell growth, migration and melanoma progression through forming a complex with IGF binding proteins.
The molecular interactions of IGF1-IGF1R binding have been dissected.
genetic association and nutrigenomic studies in population of postmenopausal women in China: Data confirm that dietary acid load is associated with postmenopausal osteoporosis; an SNP in IGF1 (rs35767) is not associated with this relationship in the population studied.
Although IGF1 treatment improved growth of Noonan syndrome (NS) mice, it did not fully reverse growth plate abnormalities, notably the decreased hypertrophic zone.
The results of the present study demonstrated that IGF1 may improve neuropathy in diabetic mice
Adipocyte-specific IGF-I ablation in obese Berlin Fat Mouse Inbred mice results in reduced adipose tissue mass and thereby alters glucose metabolism.
IGF-1 upregulated c-kit expression in c-kit-positive C-kit-positive cardiac stem cells (CSCs) resulting in enhanced CSC proliferation and migration by activating the PI3K/AKT/DNMT signaling pathway to epigenetically silence miR-193a, which negatively modifies the c-kit expression level.
glucagon and/or IGF-1 production are additional key factors in food-induced entrainment.
Combined treatment with electrical stimulation and insulin-like growth factor-1 promotes bone regeneration in vitro.
Enteric neural stem cells expressing IGF1 has been proposed as a novel cellular therapy for Hirschsprung's Disease tested in a mouse model.
Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normoglycemic conditions nor in diabetes.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis
these results indicate that IGF-I induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53-dependent manner and that IGF-I may be applied to treat nonalcoholic steatohepatitis and cirrhosis.
IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective and antiapoptotic proteins.
Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.
These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length.
The data demonstrate that miR-206 sensitizes nasopharyngeal carcinoma cells to irradiation by targeting IGF1, highlighting the therapeutic potential of miR-206 in nasopharyngeal carcinoma radiosensitization.
These results indicated that the proproliferative effects of IGF1 are mediated in response to the PI3K/protein kinase B signaling pathway.
These results suggest that Dexras1 is a critical mediator of the IGF-1 signal to activate MAPK, linking glucocorticoid signaling to IGF-1 signaling in adipogenesis.
In inflamed experimental autoimmune encephalomyelitis (EAE) spinal cord, study found a significant increased number of IGF-I expressing neurons versus a reduced number of IGFBP-1 positive neurons. Moreover, while nearly all IGF-I neurons expressed GSK3beta, some expressed it more intensely.
MGF overexpression increases the number of neural progenitor cells and promotes neurogenesis.
RIP3 and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS-induced lung injuries in vivo.
High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio.
the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.
The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin mRNA expression were down-regulated in the chronic cyanotic immature piglets.
IGFI signaling pathway regulates myofibre hypertrophy postnatally via complicated signal effectors, which may have negative impact on meat quality simultaneously.
IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
These results indicate that sorbic acid improves growth performance by regulating IGF system gene expression and hormone secretion.
In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin on cell proliferation/apoptosis, MAP kinase signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin. (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 is expressed in IVD cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor, an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1
amphioxus and zebrafish both share a similar regulatory mechanism of IGF gene expression in response to T(3), providing an evidence for the presence of a vertebrate-like TH/IGF signaling pathway in the protochordate amphioxus.
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b, a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt pathway in unfolded protein
zebrafish primordial germ cells intrinsically require IGF signaling for directional migration in vivo
plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves
These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase-mediated signaling pathways.
Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.
Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.
This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.
Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.
We found that IGF-I stimulated chondrocyte biosynthesis similarly when delivered by either exogenous or endogenous means.
Results herein remark the important role of the IGF-1gene in the fertility of dairy cows on early lactation and make the SNP IGF-1/SnaBI an interesting candidate marker for genetic improvement of fertility in dairy cattle.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN mRNA may participate in ordering duck muscle growth rates with selected development.
Our data indicate a differential expression of selected genes that comprise the IGF system in the duck liver tissue during embryonic and early PH growth and development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A