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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398
Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011
Show all 4 Pubmed References
Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN803884
de Waal, Leal, García-López, Liarte, de Jonge, Hinfray, Brion, Schulz, Bogerd: Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis. in The Journal of endocrinology 2009
Show all 2 Pubmed References
Human IGF1 Protein expressed in Insect cells (Sf9) - ABIN935729
Ablonczy, Crosson: VEGF modulation of retinal pigment epithelium resistance. in Experimental eye research 2007
Study provides evidence that IGF-1/IGF-1R (show IGF1R Proteins)/hsa (show CD24 Proteins)-let-7c axis can control the odonto/osteogenic differentiation of IGF-1-treated stem cells from apical papilla via the regulation of JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling pathways.
Circulating sex steroids, prolactin (show PRL Proteins), insulin (show INS Proteins)-like growth factor (IGF) I, IGF-binding protein 3 (show IGFBP3 Proteins), and sex hormone-binding globulin (SHBG (show SHBG Proteins)) were evaluated using backward elimination separately in women pre- and postmenopausal at blood collection.
association between serum IGFBP-1 (show IGFBPI Proteins) and IGF-I levels with advanced fibrosis in non-alcoholic fatty liver disease patients
findings suggest that the IGF1 polymorphism rs5742714 may be a genetic predictor of susceptibility and prognosis of renal cell carcinoma (show MOK Proteins).
The results of the study may help to inform future health interventions that utilize physical activity as a means to improve cognitive development in children, adolescents, and adults. Additionally, the study may assist in determining whether the putative effects occur via modification of plasma IGF-1 or BDNF (show BDNF Proteins) concentrations.
Data show the differential expression of insulin like growth factor 1 (IGF-I) transcripts isoforms in bladder cancer, revealing a distinct suppression of IGF-IEc.
Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes.
Human IGF-I propeptides and mutants were overexpressed in bovine articular chondrocytes. Secreted IGF-I propeptides stimulated articular chondrocyte biosynthetic activity as much as mature IGF-I. Of the 3 IGF-I propeptides, only proIGF-IA strongly bound to heparin, depending on N-glycosylation at Asn92 in the EA peptide.
knockdown of Sema4D (show SEMA4D Proteins) in Head and neck squamous cell carcinomas (HNSCCs)cells inhibited tumor growth and decreased the number of osteoclasts in a mouse xenograft model. Taken together, IGF-I-driven production of Sema4D (show SEMA4D Proteins) in HNSCCs promotes osteoclastogenesis and bone invasion.
analysis of IGFBP3 (show IGFBP3 Proteins)-IGF1 correlation with the risk of esophageal carcinoma
Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normoglycemic conditions nor in diabetes.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (show INS Proteins)/InsR (show INSR Proteins) and IGF-1/IGF-1R (show IGF1R Proteins) signaling. Insulin (show INS Proteins) therapy in the early stage may delay diabetic gastroparesis
these results indicate that IGF-I induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53 (show TP53 Proteins)-dependent manner and that IGF-I may be applied to treat nonalcoholic steatohepatitis and cirrhosis.
IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective and antiapoptotic proteins.
Inhibition of mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1 (show CCL2 Proteins), CCL5/RANTES (show CCL5 Proteins) and IGF-1 in vitro.
These data indicate that KSR2 functions in a cell non-autonomous fashion to regulate GH-stimulated IGF-1 expression in the liver of neonatal mice, which plays a key role in the development of body length.
The data demonstrate that miR (show MLXIP Proteins)-206 sensitizes nasopharyngeal carcinoma cells to irradiation by targeting IGF1, highlighting the therapeutic potential of miR (show MLXIP Proteins)-206 in nasopharyngeal carcinoma radiosensitization.
These results indicated that the proproliferative effects of IGF1 are mediated in response to the PI3K/protein kinase B (show AKT1 Proteins) signaling pathway.
These results suggest that Dexras1 (show RASD1 Proteins) is a critical mediator of the IGF-1 signal to activate MAPK (show MAPK1 Proteins), linking glucocorticoid signaling to IGF-1 signaling in adipogenesis.
the dipeptide Pro-Asp (show ASIP Proteins) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Proteins) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (show LEP Proteins) on cell proliferation/apoptosis, MAP kinase (show MAPK1 Proteins) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (show LEP Proteins). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (show GH1 Proteins)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Proteins).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (show EGFR Proteins) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (show EGF Proteins), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (show PGC Proteins) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (show IGFBPI Proteins)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (show AKT1 Proteins) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (show BMP4 Proteins), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (show XBP1 Proteins) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (show AKT1 Proteins) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (show STAT5A Proteins) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (show MSTN Proteins) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A