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Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN413398
Robertson, Zhu, Wu: Cellular distribution of the IGF-1R in corneal epithelial cells. in Experimental eye research 2011
Show all 4 Pubmed References
Human IGF1 Protein expressed in Escherichia coli (E. coli) - ABIN803884
de Waal, Leal, García-López, Liarte, de Jonge, Hinfray, Brion, Schulz, Bogerd: Oestrogen-induced androgen insufficiency results in a reduction of proliferation and differentiation of spermatogonia in the zebrafish testis. in The Journal of endocrinology 2009
Show all 2 Pubmed References
Human IGF1 Protein expressed in Insect cells (Sf9) - ABIN935729
Ablonczy, Crosson: VEGF modulation of retinal pigment epithelium resistance. in Experimental eye research 2007
High IGF-1 serum levels are associated with breast cancer.
association of IGF-1 with coronary collateral circulation in stable coronary artery disease
IGF-1 was negatively correlated with changes in pro-inflammatory cytokine levels in community-dwelling elderly people at risk of undernutrition
High IGF1 serum levels improve skeletal muscle performance and physical capacity.
there was a high heritability for IGF-I and IGFBP-3 (show IGFBP3 Proteins), but a low heritability for insulin (show INS Proteins) secretion and insulin (show INS Proteins) sensitivity in a group of elderly twins; in addition, study found a negative relationship between IGF-I and insulin (show INS Proteins) sensitivity, which did not seem to be strongly genetically determined
In short, thin children, despite elevated ghrelin (show GHRL Proteins) production, the low IGF-I concentration is observed, probably due to undernutrition and worse IGF-I formation. In short, normal-weight children and in short, obese ones, ghrelin (show GHRL Proteins) and IGF-I production is normal, and it seems that mechanisms responsible for their short stature are other than low IGF-I.
Individualized resistance exercise in lean patients with fibromyalgia resulted in decreases in serum IGF-1.
Data suggest that Y537S/D538G ESR1 (show ESR1 Proteins) mutant breast cancer cell lines exhibit enhanced proliferation in response to IGF1/IGF1R (show IGF1R Proteins) signaling; mechanism involves IRS1 (show IRS1 Proteins); here, knockdown of IRS1 (show IRS1 Proteins) attenuates enhanced IGF1/IGF1R (show IGF1R Proteins) signaling response in ESR1 (show ESR1 Proteins) mutant cells. (ESR1 (show ESR1 Proteins) = estrogen receptor 1 (show ESR1 Proteins); IGF1 = insulin like growth factor 1; IGF1R (show IGF1R Proteins) = IGF1 receptor; IRS1 (show IRS1 Proteins) = insulin receptor substrate 1 (show IRS1 Proteins))
Meta-analysis suggests that IGF1 gene single nucleotide polymorphism (rs5742612) is not significant associated with susceptibility to adolescent idiopathic scoliosis (AIS (show AR Proteins)) in either Asian or Caucasian populations. However, IGF1 gene rs5742612 may be associated with severity of AIS (show AR Proteins).
Fifteen minutes bicycling at moderate intensity was sufficient to acutely mobilize serum IGF-1 in women with fibromyalgia.
High IGF1 expression is sensitive to initial injury intensity induced by freeze damage.
study revealed that only BMP-6 (show BMP6 Proteins) was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 (show BMP6 Proteins) with IGF-1 might be a better alternative than BMP-2 (show BMP2 Proteins) for orthopedic surgery or bone tissue engineering approaches.
IGF-1 signaling in involved in the epithelial-mesenchymal transformation of B16-F10 (show F10 Proteins) cells and in the control of the stem cell phenotype.
Findings provided morphological evidence that T-type Cav3.2 (show CACNA1H Proteins) channel, at least partially, mediates the pain facilitation of insulin-like growth factor-1/insulin-like growth factor-1 receptor (show IGF1R Proteins) signaling in chronic inflammatory pain condition.
Conditional deletion of IGF-1 in osteocytes enhanced bony union of the fracture gap in a tibial fracture model.
IGF-I stimulated IRS-1 (show IRS1 Proteins) phosphorylation and recruitment of PKCzeta (show PRKCZ Proteins) and vimentin (show VIM Proteins) to phospho-IRS-1 (show IRS1 Proteins).
local IGF-I plays critical roles during postnatal/adult hippocampal neurogenesis.
miR (show MLXIP Proteins)-199a-3p appears to be involved in the estrogen regulatory networks that mediate bone cell autophagy, potentially by targeting IGF-1 and mTOR (show FRAP1 Proteins).
IGF-1 deficiency during a critical period during early in life results in persistent changes in post-transcriptional miRNA-mediated control of genes critical targets for vascular health, which likely contribute to the deleterious late-life cardiovascular effects known to occur with developmental IGF-1 deficiency.
this study provides new evidence in a mouse model of IGF-1 deficiency that autophagy is an adaptive response that might confer protection against persistent inflammation in the retina during ageing.
the dipeptide Pro-Asp (show ASIP Proteins) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (show FRAP1 Proteins) and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Proteins) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (show LEP Proteins) on cell proliferation/apoptosis, MAP kinase (show MAPK1 Proteins) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (show LEP Proteins). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (show GH1 Proteins)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Proteins).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (show EGFR Proteins) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (show EGF Proteins), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (show PGC Proteins) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (show IGFBPI Proteins)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (show AKT1 Proteins) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (show BMP4 Proteins), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (show XBP1 Proteins) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (show AKT1 Proteins) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (show STAT5A Proteins) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (show MSTN Proteins) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A