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leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3
Study demonstrates that regulation of astroglial responses to lipopolysaccharide administration are highly dependent on the levels of expression of pleiotrophin (show PTN Proteins) and midkine.
MDK functions in the ventral tegmental area to limit ethanol consumption and levels of CCL2 (show CCL2 Proteins)
Analyses of the melanoma secretome and validation in clinical specimens showed that the heparin-binding factor (show PTN Proteins) midkine is a systemic inducer of neo-lymphangiogenesis that defines patient prognosis. This role of midkine was linked to a paracrine activation of the mTOR (show FRAP1 Proteins) pathway in lymphatic endothelial cells.
MK serves an indispensable role in the NFAT (show NFATC1 Proteins)-regulated activation of CD4 (show CD4 Proteins)(+) T cells and Th1 (show HAND1 Proteins) cell differentiation.
Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.
Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.
This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.
clonidine-induced analgesia was significantly enhanced in PTN (show PTN Proteins)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test
midkine plays a critical role in cardiac hypertrophy and remodelling.
MDK promoted gemcitabine resistance of biliary tract cancer through inducing epithelial to mesenchymal transition via upregulating Notch1 (show NOTCH1 Proteins).
These results demonstrate that analysis of IHC expression patterns of MK and NANOG in pretreatment biopsy specimens during the work-up period can provide a more definitive prognosis prediction for each oral squamous cell carcinoma (OSCC) patient that can help clinicians to develop a more precise individual treatment modality.
Elevated plasma midkine and pleiotrophin (show PTN Proteins) levels in systemic lupus erythematosus (SLE) patients suggest their involvement in this disease.
Urinary midkine may be an effective biological marker for early diagnosis of acute kidney injury.
suppression of midkine gene promoted the antitumoral effect of cisplatin on human gastric cell line AGS (show JAG1 Proteins) in vitro and in vivo via Notch (show NOTCH1 Proteins) signaling pathway.
Results revealed that ectopic overexpression of midkine in HCC (show FAM126A Proteins) cell lines with IGF-1R (show IGF1R Proteins) inhibition markedly rescued inhibition of HCC (show FAM126A Proteins) cell proliferation, migration, and invasion. These data imply that inhibition of IGF-1R (show IGF1R Proteins) suppresses HCC (show FAM126A Proteins) growth and invasion via down-regulating midkine expression.
Midkine is involved in bowel inflammation in UC and lymph node metastasis in CRC (show CALR Proteins), rendering midkine an attractive target for their treatment.
Data suggest that mature KLK9 (kallikrein 9 (show KLK9 Proteins)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (show KLK9 Proteins) appears to extend to KLK10 (show KLK10 Proteins) and midkine; enzyme activity is enhanced by Mg2 (show MUC7 Proteins)+ and Ca2 (show CA2 Proteins)+, but is reversibly attenuated by Zn2+; KLK9 (show KLK9 Proteins) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
midkine may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients.
Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (show IGF1 Proteins) gene expression, in cumulus-granulosa cells.
Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.
MK is able to maintain a proliferative PGC (show PGC Proteins) phenotype mediated by the suppression of DAZL (show DAZL Proteins) in early germ cells
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
, pleiotrophic factor-alpha-2
, pleiotrophic factor-alpha2
, retinoic acid-induced differentiation factor
, amphiregulin-associated protein
, midgestation and kidney protein
, neurite outgrowth-promoting factor 2
, retinoic acid inducible factor
, retinoic acid-induced heparin-binding protein