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Midkine expression is not significantly linked to metastatic disease in pancreatic ductal adenocarcinoma.
High midkine expression is associated with invasion and metastasis in Hepatocellular Carcinoma.
This study has demonstrated an important association between increased serum MK (midkine)levels and risk factors of atherosclerosis such as HT(Hypertension),increased total and LDL cholesterol.
Midkine can be considered as both a differentiating factor and a molecular-targeted therapy in odontogenic lesions
The data of this study showed that the serum MK concentration in ASD (show ARSD Proteins) patients is significantly higher than healthy controls.
MDK promoted gemcitabine resistance of biliary tract cancer through inducing epithelial to mesenchymal transition via upregulating Notch1 (show NOTCH1 Proteins).
These results demonstrate that analysis of IHC expression patterns of MK and NANOG in pretreatment biopsy specimens during the work-up period can provide a more definitive prognosis prediction for each oral squamous cell carcinoma (OSCC) patient that can help clinicians to develop a more precise individual treatment modality.
Elevated plasma midkine and pleiotrophin (show PTN Proteins) levels in systemic lupus erythematosus (SLE) patients suggest their involvement in this disease.
Urinary midkine may be an effective biological marker for early diagnosis of acute kidney injury.
suppression of midkine gene promoted the antitumoral effect of cisplatin on human gastric cell line AGS (show JAG1 Proteins) in vitro and in vivo via Notch (show NOTCH1 Proteins) signaling pathway.
leukocyte domiciled midkine mediates increased plasma levels of VEGFA relevant for upregulation of endothelial nitric oxide synthase 1 and 3
Study demonstrates that regulation of astroglial responses to lipopolysaccharide administration are highly dependent on the levels of expression of pleiotrophin (show PTN Proteins) and midkine.
MDK functions in the ventral tegmental area to limit ethanol consumption and levels of CCL2 (show CCL2 Proteins)
Analyses of the melanoma secretome and validation in clinical specimens showed that the heparin-binding factor (show PTN Proteins) midkine is a systemic inducer of neo-lymphangiogenesis that defines patient prognosis. This role of midkine was linked to a paracrine activation of the mTOR (show FRAP1 Proteins) pathway in lymphatic endothelial cells.
MK serves an indispensable role in the NFAT (show NFATC1 Proteins)-regulated activation of CD4 (show CD4 Proteins)(+) T cells and Th1 (show HAND1 Proteins) cell differentiation.
Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.
Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.
This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.
clonidine-induced analgesia was significantly enhanced in PTN (show PTN Proteins)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test
midkine plays a critical role in cardiac hypertrophy and remodelling.
Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.
MK is able to maintain a proliferative PGC (show PGC Proteins) phenotype mediated by the suppression of DAZL (show DAZL Proteins) in early germ cells
Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (show IGF1 Proteins) gene expression, in cumulus-granulosa cells.
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
, midgestation and kidney protein
, neurite outgrowth-promoting factor 2
, retinoic acid inducible factor
, retinoic acid-induced differentiation factor
, pleiotrophic factor-alpha-2
, pleiotrophic factor-alpha2
, retinoic acid-induced heparin-binding protein
, midkine b
, midkine-related growth factor b
, pleiotrophin 2