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anti-Human MERTK Antibodies:
anti-Rat (Rattus) MERTK Antibodies:
anti-Mouse (Murine) MERTK Antibodies:
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Mouse (Murine) Polyclonal MERTK Primary Antibody for CyTOF, FACS - ABIN4899759
Nascimento, Huang, Smith, Everts, Lam, Bassity, Gautier, Randolph, Pearce: Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis. in PLoS pathogens 2014
Show all 23 Pubmed References
Human Polyclonal MERTK Primary Antibody for CM, ICC - ABIN2746864
Keating, Salzberg, Sather, Liang, Nickoloff, Anwar, Deryckere, Hill, Joung, Sawczyn, Park, Curran-Everett, McGavran, Meltesen, Gore, Johnson, Graham: Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase. in Oncogene 2006
Show all 16 Pubmed References
Human Polyclonal MERTK Primary Antibody for CM, ICC - ABIN2746860
Wu, Singh, Georgescu, Birge: A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. in Journal of cell science 2005
Show all 9 Pubmed References
Human Polyclonal MERTK Primary Antibody for CyTOF, FACS - ABIN4899963
Eken, Martin, Sadallah, Treves, Schaller, Schifferli: Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent anti-inflammatory pathway in macrophages. in The Journal of biological chemistry 2010
Show all 8 Pubmed References
Mouse (Murine) Polyclonal MERTK Primary Antibody for FACS, WB - ABIN5012952
Ikarashi, Nakashima, Kinoshita, Sato, Nakashima, Miyazaki, Nishiyama, Yamamoto, Seki: Distinct development and functions of resident and recruited liver Kupffer cells/macrophages. in Journal of leukocyte biology 2014
Show all 8 Pubmed References
Human Monoclonal MERTK Primary Antibody for FACS - ABIN4895670
Graham, Salzberg, Kurtzberg, Sather, Matsushima, Keating, Liang, Lovell, Williams, Dawson, Schell, Anwar, Snodgrass, Earp: Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 5 Pubmed References
Mouse (Murine) Monoclonal MERTK Primary Antibody for FACS - ABIN4896617
Stijlemans, Cnops, Naniima, Vaast, Bockstal, De Baetselier, Magez: Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis. in PLoS neglected tropical diseases 2015
Show all 4 Pubmed References
Human Monoclonal MERTK Primary Antibody for ELISA, WB - ABIN969283
McGough, Cummings: Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye. in The Proceedings of the Nutrition Society 2005
Show all 3 Pubmed References
Human Polyclonal MERTK Primary Antibody for CM, ICC - ABIN2750536
Mahajan, Earp: An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. in The Journal of biological chemistry 2004
Show all 3 Pubmed References
Human Monoclonal MERTK Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899148
Shiozawa, Pedersen, Taichman: GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. in Experimental hematology 2010
Show all 3 Pubmed References
Study describes a novel cellular pathway involved in diabetic efferocytosis, wherein diabetes-induced decrease in miR (show MLXIP Antibodies)-126 expression results in upregulation of ADAM9 (show ADAM9 Antibodies) expression that in-turn leads proteolytic cleavage of MerTK and formation of inactive soluble Mer. Decrease in MerTK phosphorylation leads to reduced downstream cytoskeletal signaling required for engulfment and thus decreases efferocytosis.
Phosphatidylserine mediated hyperactivation of Mertk.MERTK promotes epithelial cell efferocytosis in a tyrosine kinase (show TXK Antibodies)-dependent manner.MERTK role in AKT (show AKT1 Antibodies)-dependent drug resistance.
STK 11 (show STK11 Antibodies) testing can confirm those at risk of Peutz-Jeghers syndrome, who require lifelong surveillance, and possibly release those with a simple dermatosis, such as Laugier-Hunziker syndrome, from invasive and thus potentially harmful surveillance.
The broad-spectrum activity mediated by UNC2025 in leukemia patient samples and xenograft models, alone or in combination with cytotoxic chemotherapy, supports continued development of MERTK inhibitors for treatment of leukemia
The expression of MerTK and AxlTK varied according to the deposition of immunoglobulin and complements on glomeruli. Both MerTK and AxlTK expressions were increased on glomeruli and varied according to pathological classifications.
Study identified the Gas6 (show GAS6 Antibodies)/TAM (show CCNA1 Antibodies) receptor pathway with Tyro3 (show TYRO3 Antibodies) and Mer as novel targets in colorectal cancer.
MERTK is frequently overexpressed in head and neck squamous cell carcinoma and plays an important role in tumor cell motility.
these data suggest that endogenous GAS6 (show GAS6 Antibodies) and Mer receptor signaling contribute to the establishment of prostate cancer stem cells in the bone marrow microenvironment
Sequence analysis revealed that the proband was a compound heterozygote with two independent mutations in MERTK, a novel nonsense mutation (c.2179C > T) and a previously reported missense variant (c.2530C > T). The proband's affected brother also had both mutations
this study shows that viral infection sensitizes fetal membranes by MERTK Inhibition
Tumor macrophage expression of Mertk is a therapeutic target to prevent tumor recurrence following radiation therapy.
Hypercapnic Acidosis Regulates Mer (show ERH Antibodies) Tyrosine Kinase Receptor (show KDR Antibodies) Shedding and Activity.
GC B (show NPR2 Antibodies) cell-intrinsic sensing of self-RNA, but not self-DNA, from dead cells in GCs (show UGCG Antibodies) drives enhanced GC responses in Mer (show ERH Antibodies)(-/-) mice. Mer (show ERH Antibodies) loss in dendritic cells promotes enhanced T cell activation and proinflammatory cytokine production. Mer (show ERH Antibodies) immunoregulatory signaling in APCs (show APCS Antibodies) regulates B cell selection and autoimmunity. The phagocytic and immunomodulatory functions of Mer (show ERH Antibodies) regulate GC responses preventing autoimmunity.
Monocyte-induced MerTK cleavage on proreparative MHCII(LO) cardiac macrophages is a novel contributor to myocardial ischemic reperfusion injury.
evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (show TYRO3 Antibodies) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.
these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages
the reciprocal activation of Axl (show AXL Antibodies) and Mer (show ERH Antibodies) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (show RPS19 Antibodies)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.
Axl (show AXL Antibodies), Mertk and Tyro3 (show TYRO3 Antibodies) receptors are not required for Zika virus entry and infection.
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
MER receptor tyrosine kinase
, STK kinase
, proto-oncogene c-Mer
, receptor tyrosine kinase MerTK
, tyrosine-protein kinase Mer
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, G-protein coupled receptor 41
, chemoattractant receptor-like 2
, chemokine receptor-like 2
, membrane estrogen receptor
, Tyro 12
, proto-oncogene tyrosine-protein kinase Mer
, Receptor tyrosine tinase gene probably the gene for Rdy
, proto-oncogene tyrosine-protein kinase MER
, retinal dystrophy
, c-eyk proto-oncogene
, c-mer proto-oncogene tyrosine kinase
, tyrosine-protein kinase Mer-like