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NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (show PSEN1 Proteins) (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 (show PSEN1 Proteins) mice as well as reduced microgliosis and astrogliosis with no effect on plaque load.
data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB (show NFKB1 Proteins)-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance.
These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4 (show CD4 Proteins)(+) T cell exhaustion.
These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E (show CCNE1 Proteins) expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies.
Overexpression of either ca-Nfatc2 or ca-Nfatc1 (show NFATC1 Proteins) in mouse islets enhanced insulin (show INS Proteins) secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin (show INS Proteins) secretion vs. b-cell proliferation are regulated by NFAT (show NFATC1 Proteins)
our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4 (show CD4 Proteins)(+)/CD8 (show CD8A Proteins)(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation.
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Proteins)-mediated maintenance of whole body homeostasis
NFAT (show NFATC1 Proteins) directs signaling enzymes to gene promoters in islets.
FOXP3 (show FOXP3 Proteins) can inhibit NFAT (show NFATC1 Proteins) driven expression of CD40L (show CD40LG Proteins) and IL-17 (show IL17A Proteins) in CD4 (show CD4 Proteins) T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
Our data have shown for the first time the regulation of CacyBP/SIP (show CACYBP Proteins) gene expression by NFAT1. Since NFAT (show NFATC1 Proteins) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP (show CACYBP Proteins) in the immune system.
An interaction of NFAT1 and the beta-catenin (show CTNNB1 Proteins) pathway, validate lysophosphatidic acid as an in vivo activator of beta-catenin (show CTNNB1 Proteins)-dependent transcription during allograft fibrogenesis.
the expression of NFATc2 promotes melanoma dedifferentiation and immune escape
NFAT1 is stimulated by subplasmalemmal Ca2 (show CA2 Proteins)+ microdomains, whereas NFAT4 (show NFATC3 Proteins) additionally requires Ca2 (show CA2 Proteins)+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors.
NFAT1 overexpression is associated with Melanoma Tumor Growth and Metastasis.
revealed more than 170 NFAT (show NFATC1 Proteins)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Proteins) and NFATc2 in T cells, such as Raptor (show RPTOR Proteins), CHEK1 (show CHEK1 Proteins), CREB1 (show CREB1 Proteins), RUNX1 (show RUNX1 Proteins), SATB1 (show SATB1 Proteins), Ikaros (show IKZF1 Proteins), and Helios (show ZNFN1A2 Proteins).
NFAT1 silencing could suppress cell migration and invasion through MMP-3 (show MMP3 Proteins).
FOXP1 (show FOXP1 Proteins) has protein-protein interaction with NFAT1 on DNA and enhances breast cancer cell migration by repressing NFAT1 transcriptional activity.
we describe a novel mechanism by which GSK-3beta fine-tunes NFATc2 and STAT3 (show STAT3 Proteins) transcriptional networks to integrate upstream signaling events that govern pancreatic cancer progression and growth.
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
, nuclear factor of activated T-cells, cytoplasmic 2-like
, NFAT pre-existing subunit
, T-cell transcription factor NFAT1
, nuclear factor of activated T-cells, cytoplasmic 2
, NFAT transcription complex, preexisting component
, T cell transcription factor NFAT1
, nuclear factor of activated T-cells, preexisting component
, preexisting nuclear factor of activated T-cells 2