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anti-Mouse (Murine) NFATC1 Antibodies:
anti-Human NFATC1 Antibodies:
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Human Monoclonal NFATC1 Primary Antibody for IF, IP - ABIN967559
Crabtree: Contingent genetic regulatory events in T lymphocyte activation. in Science (New York, N.Y.) 1989
Show all 5 Pubmed References
Hamster Monoclonal NFATC1 Primary Antibody for ChIP, GS - ABIN152773
Alpini, Franchitto, Demorrow, Onori, Gaudio, Wise, Francis, Venter, Kopriva, Mancinelli, Carpino, Stagnitti, Ueno, Han, Meng, Glaser: Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1. in Hepatology (Baltimore, Md.) 2011
NFAT2 is an important regulator for the anergic phenotype of chronic lymphocytic leukaemia.
NFATc1 controls the cytotoxicity and metabolic switching of activated CD8 (show CD8A Antibodies)(+) T cells required for optimal response to bacteria and tumor cells.
ATF3 (show ATF3 Antibodies) is a new co-factor of c-Fos and NFATc1 to activate osteoclast differentiation and activity.
NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
IKKepsilon (show IKBKE Antibodies) promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon (show IKBKE Antibodies) as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
Transplantation from GRIM19 (show NDUFA13 Antibodies)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (show RCAN3 Antibodies) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (show KEAP1 Antibodies)/Nrf2 (show NFE2L2 Antibodies) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (show CTSK Antibodies) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (show NFATC3 Antibodies)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Exposure to UVB radiation induces nuclear translocation and stimulates binding between NFAT5 (show NFAT5 Antibodies) and NF-kappaB (show NFKB1 Antibodies) proteins in HLE (show ELANE Antibodies)-B3 cells. These interactions may form part of the biochemical mechanism of cataractogenesis in UVB-irradiated HLECs.
data identified a novel role of SFKs in preventing aberrant NFAT1 (show NFAT1 Antibodies) activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (show LYST Antibodies) (cg16962115, FDR = 1.24E-04), CADM1 (show CADM1 Antibodies) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (show ABCA1 Antibodies)-dependent mechanism in which local TNF (show TNF Antibodies) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF Antibodies), TNFR1 (show TNFRSF1A Antibodies), or TNFR2 (show TNFRSF1B Antibodies) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (show FLVCR1 Antibodies)) specimens and PCa (show FLVCR1 Antibodies) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (show NFAT1 Antibodies) in T cells, such as Raptor (show RPTOR Antibodies), CHEK1 (show CHEK1 Antibodies), CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros (show IKZF1 Antibodies), and Helios (show ZNFN1A2 Antibodies).
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac