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anti-Human PAK4 Antibodies:
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Human Monoclonal PAK4 Primary Antibody for WB - ABIN967342
Abo, Qu, Cammarano, Dan, Fritsch, Baud, Belisle, Minden: PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. in The EMBO journal 1999
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Bat Polyclonal PAK4 Primary Antibody for WB - ABIN610860
Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human Polyclonal PAK4 Primary Antibody for IHC, ELISA - ABIN1002957
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002
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Human Polyclonal PAK4 Primary Antibody for ELISA, IF - ABIN4343475
Liu, Yang, Liu, Liu, Zhang, Xu, Zhu, Xu: p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. in Urologic oncology 2015
Human Polyclonal PAK4 Primary Antibody for WB - ABIN4343476
Cianciola, Chung, Manor, Carlin: Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. in Journal of virology 2017
The present study demonstrates that miR (show MLXIP Antibodies)-145 plays an important role in inhibiting cell migration by directly targeting PAK4, and identifies miR (show MLXIP Antibodies)-145-PAK4-LIMK1 (show LIMK1 Antibodies)-cofilin (show CFL1 Antibodies) as a novel regulatory pathway that contributed to colorectal cancer metastasis.
These findings revealed a novel glucose metabolism-related mechanism of PAK4 in promoting colon cancer cell growth, suggesting that PAK4 and/or G6PD (show G6PD Antibodies) blockage might be a potential therapeutic strategy for colon cancer.
PAK4 (but not PAK1 (show PAK1 Antibodies)) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF (show ARHGEF11 Antibodies).
these results indicate that PAK4 confers CDDP resistance via the activation of MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathways. PAK4 and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathways can reciprocally activate each other.
PAK4 activity was markedly decreased in postmortem brain tissue from Parkinson's disease (PD) patients and in rodent models of PD. Expression of constitutively active PAK4(S445N/S474E) (caPAK4) protected DA neurons in both the 6-hydroxydopamine and alpha-synuclein rat models of PD and preserved motor function.
Our results indicate that PAK4 plays an important role in the potentiation of insulin (show INS Antibodies) secretion by fatty acids downstream of GPR40 (show FFAR1 Antibodies).
PAK4 downregulation decreased PPARgamma (show PPARG Antibodies)-mediated Nox1 (show NOX1 Antibodies) expression and suppressed EMT (show ITK Antibodies) in IR-treated glioma cells.
miR (show MLXIP Antibodies)-1271/Zic2 (show ZIC2 Antibodies)/PAK4 axis plays an important role in hepatocellular carcinoma progression.
findings suggest that PAK4-activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling is both kinase-dependent and -independent, which contributes to breast cancer progression
Functional role and therapeutic targeting of PAK4 in multiple myeloma has been presented.
PAK4 microparticles may have a role in the ventilation-induced lung injury process
These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.
PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (show CREB1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.
PAK4 phosphorylates Par6B (show PARD6B Antibodies) at Ser143 blocking its interaction with Cdc42 (show CDC42 Antibodies).
Defined here is the overlap in phosphopeptides regulated by K-Ras (show HRAS Antibodies), Cdc42 (show CDC42 Antibodies), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.
These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart
p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.
the transient increase in PAK4 levels at early G1 reduces p21 (show D4S234E Antibodies) levels, thereby abrogating the activity of CDK4 (show CDK4 Antibodies)/CDK6 (show CDK6 Antibodies) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way
Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.
results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells
pak4 is dispensable in zebrafish.
Zebrafish pak4 is required for primitive myeloid cell development.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, p21(CDKN1A)-activated kinase 4
, p21-activated kinase 4
, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
, serine/threonine-protein kinase PAK 4
, p21 (CDKN1A)-activated kinase 4
, p21 protein (Cdc42/Rac)-activated kinase 4