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anti-Human PDGFB Antibodies:
anti-Mouse (Murine) PDGFB Antibodies:
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Human Polyclonal PDGFB Primary Antibody for IF (p), IHC (p) - ABIN725990
Morita, Furube, Mannari, Okuda, Tatsumi, Wanaka, Miyata: Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. in Cell and tissue research 2015
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Human Polyclonal PDGFB Primary Antibody for ELISA, WB - ABIN544637
Laprise, Grondin, Cayer, McDonald, Dubois et al.: Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin ... in Blood 2002
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Human Polyclonal PDGFB Primary Antibody for WB - ABIN3043599
Hong, Hong, Chen, Wang, Hong: Investigation of the protective effect of erythropoietin on spinal cord injury in rats. in Experimental and therapeutic medicine 2012
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Mouse (Murine) Polyclonal PDGFB Primary Antibody for WB - ABIN5518861
Wang, Leung, Xu: Low-intensity ultrasound-induced cellular destruction and autophagy of nasopharyngeal carcinoma cells. in Experimental and therapeutic medicine 2011
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Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115468
van Steensel, Paridaens, van Meurs, van Hagen, van den Bosch, Kuijpers, Drexhage, Hooijkaas, Dik: Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy. in The Journal of clinical endocrinology and metabolism 2012
Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115467
Harrison, Kharbanda, Cunningham, McLellan, Hayes: Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury. in Journal of clinical pathology 1989
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Human Monoclonal PDGFB Primary Antibody for CyTOF, FACS - ABIN258832
Schito, Rey, Tafani, Zhang, Wong, Russo, Russo, Semenza: Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2012
Cow (Bovine) Polyclonal PDGFB Primary Antibody for IHC (p) - ABIN4344538
Ulvé, Rault, Bahin, Lagoutte, Abadie, De Brito, Coindre, Botherel, Rousseau, Wucher, Cadieu, Thieblemont, Hitte, Cornevin, Cabillic, Bachelot, Gilot, Hennuy, Guillaudeux, Le Goff, Derrien, Hédan et al.: Discovery of Human-Similar Gene Fusions in Canine Cancers. ... in Cancer research 2017
Nine of 11 dermatofibrosarcoma protuberans tumors (82%) had rearrangement of PDGFB by fluorescence in situ hybridization.
we identified two potential susceptibility loci for PC risk, which are located in PDGFB at 22q13.1
Treating HepG2 cells with hepatotoxicants resulted in a significant increase in mRNA expression of platelet-derived growth factor BB (PDGF-BB) and transforming growth factor beta (TGFbeta).
The morphology and immunophenotype of all 6 cases was analogous to those with the canonical COL1A1-PDGFB fusion; none of the cases showed fibrosarcomatous transformation. This study illustrates that the COL6A3-PDGFD fusion product is rare in dermatofibrosarcoma protuberans, and associated with an apparent predilection for breast
PDGF-B expression was found in ovarian tumor microvessels in 72% of cases. High expression of PDGF in pericapillary cells was strongly associated with high expression of this marker in cancer cells. Significant correlations between PDGF-B and nestin expression in malignant tumor microvessels were also found.
SOX7 transcription factor mediates PDGF-BB-induced IL-33 expression.
High expression of PDGF-BB may be involved in the pathogenesis of Graves' disease. CCR2-positive macrophages may induce the expression of PDGF-BB through HIF-1alpha signal.
rhPDGF-BB promoted the proliferation of hADSCs via miR-363/PI3K/Akt pathway, indicating that rhPDGF-BB combined with ADSCs could treat Achilles tendinitis via miR-363/PI3K/Akt pathway.
This study identifies the mbPDGF-BB in cell derived extracellular vesicles as a relevant mediator of diabetes-associated vascular smooth muscle cell resistance to apoptosis.
This review showed that PDGFB was one of the common gene involved included with brain calcification.
Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 gene.
Transglutaminase type 2 affects cell migration through post-translational modification of PDGF-BB.
PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to severe fever with thrombocytopenia syndrome in Chinese individuals.
PDAP-1 as an effecter of PDGF signaling in glioma cells
High PDGFB expression is associated with gastric cancer.
We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy patients expressed PDGF-BB.
Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma.
Insulin treatment caused sustained Akt activity, whereas EGF or PDGF-AA promoted transient signaling; PDGF-BB produced sustained responses at higher concentrations.Transient responses to EGF were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I caused full Akt activation
high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.
High PDGFB expression is associated with glioma.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Data indicate that ERas/PDGFbetaR complex could play a role in the pathogenesis of bovine papillomavirus-associated bladder neoplasia.
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt/Stat3 signaling pathway.
These results provide strong genetic evidence that the transmembrane domains of the E5 protein of bovine papillomavirus 1 and the platelet-derived growth factor beta receptor contact one another directly.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype.
The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies.
Myeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Increased expression of STAT5b + PDGFB led to increased expression of downstream STAT5b targets.
Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2-null mice.
The endogenous levels of PDGF-BB, increases CD31(hi)endomucin(hi) vessel number and stimulates bone formation in ovariectomy mice.
These findings thus implicate a novel role of PDGF-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier
The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination
The signaling pathways of VEGF and PDGF are crucial mediators for determining proliferation of endothelial cells and oligodendrocytes in the neurohypophysis of adult mice.
Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels
Tumor PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis.
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice.
endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts
Data indicate a significant impairment of the activation mechanisms by PDGF-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta was applied.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit
, Platelet-derived growth factor B chain