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anti-Human PDGFB Antibodies:
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Human Polyclonal PDGFB Primary Antibody for IF (p), IHC (p) - ABIN725990
Morita, Furube, Mannari, Okuda, Tatsumi, Wanaka, Miyata: Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. in Cell and tissue research 2015
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Human Polyclonal PDGFB Primary Antibody for WB - ABIN3043599
Hong, Hong, Chen, Wang, Hong: Investigation of the protective effect of erythropoietin on spinal cord injury in rats. in Experimental and therapeutic medicine 2012
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Human Monoclonal PDGFB Primary Antibody for CyTOF, FACS - ABIN258832
Schito, Rey, Tafani, Zhang, Wong, Russo, Russo, Semenza: Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2012
Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115467
Harrison, Kharbanda, Cunningham, McLellan, Hayes: Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury. in Journal of clinical pathology 1989
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Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115468
van Steensel, Paridaens, van Meurs, van Hagen, van den Bosch, Kuijpers, Drexhage, Hooijkaas, Dik: Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy. in The Journal of clinical endocrinology and metabolism 2012
Cow (Bovine) Polyclonal PDGFB Primary Antibody for IHC (p) - ABIN4344538
Ulvé, Rault, Bahin, Lagoutte, Abadie, De Brito, Coindre, Botherel, Rousseau, Wucher, Cadieu, Thieblemont, Hitte, Cornevin, Cabillic, Bachelot, Gilot, Hennuy, Guillaudeux, Le Goff, Derrien, Hédan et al.: Discovery of Human-Similar Gene Fusions in Canine Cancers. ... in Cancer research 2017
we identified two potential susceptibility loci for PC risk, which are located in PDGFB at 22q13.1
Treating HepG2 cells with hepatotoxicants resulted in a significant increase in mRNA expression of platelet-derived growth factor BB (PDGF (show PDGFA Antibodies)-BB) and transforming growth factor beta (TGFbeta (show TGFB1 Antibodies)).
The morphology and immunophenotype of all 6 cases was analogous to those with the canonical COL1A1 (show COL1A1 Antibodies)-PDGFB fusion; none of the cases showed fibrosarcomatous transformation. This study illustrates that the COL6A3 (show COL6a3 Antibodies)-PDGFD (show PDGFD Antibodies) fusion product is rare in dermatofibrosarcoma protuberans, and associated with an apparent predilection for breast
PDGF-B expression was found in ovarian tumor microvessels in 72% of cases. High expression of PDGF (show PDGFA Antibodies) in pericapillary cells was strongly associated with high expression of this marker in cancer cells. Significant correlations between PDGF-B and nestin (show NES Antibodies) expression in malignant tumor microvessels were also found.
SOX7 transcription factor (show SOX7 Antibodies) mediates PDGF (show PDGFA Antibodies)-BB-induced IL-33 (show IL33 Antibodies) expression.
High expression of PDGF (show PDGFA Antibodies)-BB may be involved in the pathogenesis of Graves' disease. CCR2 (show CCR2 Antibodies)-positive macrophages may induce the expression of PDGF (show PDGFA Antibodies)-BB through HIF-1alpha (show HIF1A Antibodies) signal.
rhPDGF-BB promoted the proliferation of hADSCs via miR (show MLXIP Antibodies)-363/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway, indicating that rhPDGF-BB combined with ADSCs could treat Achilles tendinitis via miR (show MLXIP Antibodies)-363/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway.
This review showed that PDGFB was one of the common gene involved included with brain calcification.
Rare Skin Tumor Dermatofibrosarcoma Protuberans (DFSP) is characterized by the translocation of the PDGFB gene to the collagen 1A1 (show COL1A1 Antibodies) gene.
Transglutaminase type 2 affects cell migration through post-translational modification of PDGF (show PDGFA Antibodies)-BB.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Antibodies)) and transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Antibodies)) and decreased the expression of neprilysin (NEP (show MME Antibodies)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Antibodies)/Stat3 (show STAT3 Antibodies) signaling pathway.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Antibodies)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
microRNA let-7g suppresses PDGF (show PDGFA Antibodies)-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype.
The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA (show PDGFRA Antibodies)-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies.
Myeloid cell-derived PDGF (show PDGFA Antibodies) contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition.
These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Antibodies), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Antibodies), FGF-2 (show FGF2 Antibodies) and PDGF (show PDGFA Antibodies)-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Antibodies) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Antibodies) cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 (show PAX3 Antibodies) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Data indicate a significant impairment of the activation mechanisms by PDGF (show PDGFA Antibodies)-BB was shown after a hammerhead ribozyme targeting the membrane receptor PDGFR-beta (show PDGFRB Antibodies) was applied.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit
, Platelet-derived growth factor B chain