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anti-Human Phospholipase C gamma 1 Antibodies:
anti-Rat (Rattus) Phospholipase C gamma 1 Antibodies:
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Human Polyclonal Phospholipase C gamma 1 Primary Antibody for WB - ABIN2801946
Burgess, Dionne, Kaplow, Mudd, Friesel, Zilberstein, Schlessinger, Jaye: Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. in Molecular and cellular biology 1990
Show all 4 Pubmed References
Human Polyclonal Phospholipase C gamma 1 Primary Antibody for WB - ABIN362720
DeBell, Stoica, Verí, Di Baldassarre, Miscia, Graham, Rellahan, Ishiai, Kurosaki, Bonvini: Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction. in Molecular and cellular biology 1999
Show all 3 Pubmed References
Human Polyclonal Phospholipase C gamma 1 Primary Antibody for WB - ABIN362064
Hsieh, Liu, Hsu, Jayakumar, Chou, Wang, Hsiao, Sheu et al.: Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 ... in Free radical biology & medicine 2010
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Human Monoclonal Phospholipase C gamma 1 Primary Antibody for IF, PLA - ABIN562265
Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. in Molecular & cellular proteomics : MCP 2013
Human Polyclonal Phospholipase C gamma 1 Primary Antibody for IF (p), IHC (p) - ABIN744908
Diaz-Flores, Goldschmidt, Depeille, Ng, Akutagawa, Krisman, Crone, Burgess, Williams, Houseman, Shokat, Sampath, Bollag, Roose, Braun, Shannon: PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. in Science signaling 2013
Human Polyclonal Phospholipase C gamma 1 Primary Antibody for ELISA, ICC - ABIN6271944
Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. in Oncotarget 2017
Human Monoclonal Phospholipase C gamma 1 Primary Antibody for ICS - ABIN1177236
Yu, Fukami, Itoh, Takenawa: Phosphorylation of phospholipase Cgamma1 on tyrosine residue 783 by platelet-derived growth factor regulates reorganization of the cytoskeleton. in Experimental cell research 1998
Data suggest that FGFR3 (show FGFR3 Antibodies) with mutation found in SADDAN (but not FGFR3 (show FGFR3 Antibodies) with mutation found in TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin (show PXN Antibodies); binding of FGFR3 (show FGFR3 Antibodies) to PLCG1 appears to be involved. (FGFR3 (show FGFR3 Antibodies) = fibroblast growth factor receptor 3 (show FGFR3 Antibodies); SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II)
PLCgamma2 (show PLCG2 Antibodies) plays a critical role for Ca(2 (show CA2 Antibodies)+) Flux in HCECs stimulated by A. fumigatus hyphae. Syk (show SYK Antibodies) acts upstream of PLCgamma2 (show PLCG2 Antibodies) in the Dectin-1 (show CLEC7A Antibodies) signaling pathway.
a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 (show ZAP70 Antibodies) and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76 (show LCP2 Antibodies)-associated proteins, including previously established Lck (show LCK Antibodies) substrate phosphorylation sites within this complex.
Syk (show SYK Antibodies)-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (show PLC Antibodies) gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 (show PLCG2 Antibodies) in adipogenesis.
PLCG1, along with ITGA4 (show ITGA4 Antibodies) are regulated by miR (show MLXIP Antibodies)-30b in clinical samples of coronary artery cells from coronary atherosclerosis patients.
the central biological role of the novel IL-2 (show IL2 Antibodies)-R/Lck (show LCK Antibodies)/PLCgamma/PKCtheta (show PRKCQ Antibodies);/alphaPIX (show ARHGEF6 Antibodies)/Rac1 (show RAC1 Antibodies)/PYGM (show PYGM Antibodies) signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.
LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity
Dysregulation of primary PLC (show HSPG2 Antibodies) signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
The products of PLC (show HSPG2 Antibodies)-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review)
1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR (show CYP27B1 Antibodies)/PLC-gamma1/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients.
This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.
Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2 (show CA2 Antibodies)+ flux, NF-AT (show NFATC3 Antibodies) and AP-1 (show JUN Antibodies) activation.
PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src (show SRC Antibodies) homology (SH2C) domain.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
Smooth muscle PLCgamma1-Akt (show AKT1 Antibodies)-mediated Notch1 (show NOTCH1 Antibodies) signaling is crucial for intima formation in vascular injury.
Findings provide evidence that PLCgamma1 is critical for synaptic function and plasticity and that the loss of PLCgamma1 from the forebrain results in manic-like behavior.
our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development.
Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 (show RUNX1 Antibodies) and subsequent PU.1 upregulation while subsequent rescue of RUNX1 (show RUNX1 Antibodies) in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation.
study shows that PLCgamma1 controls osteoclast numbers via a CSF-1 (show CSF1 Antibodies)-dependent DAG/beta-catenin (show CTNNB1 Antibodies)/cyclinD1 pathway.
this study shows that PLC-gamma1 contributes to protective activity of LAT (show LAT Antibodies) activity in vivo
PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review]
FGFR1 (show FGFR1 Antibodies)/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.
Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
muscle of the heart uses the VEGF (show VEGFA Antibodies)-PLCgamma1 cascade to control the strength of the heart beat
genetic analyses suggest that Vegf (show VEGFA Antibodies)/Plcg1 signaling acts at multiple time points and in different signaling contexts to mediate distinct aspects of artery development
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
, monophosphatidylinositol phosphodiesterase
, phosphatidylinositol phospholipase C
, phosphoinositidase C
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-gamma-1
, phospholipase C, gamma 1 (formerly subtype 148)
, phospholipase C-148
, phospholipase C-II
, phospholipase C-gamma-1
, triphosphoinositide phosphodiesterase
, PLC gamma 1
, phospholipase C-gamma-1b
, phospholipase C, gamma 1
, cell differentiation and embryonic development
, dead beat