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anti-Human SHC1 Antibodies:
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Mouse (Murine) Polyclonal SHC1 Primary Antibody for WB - ABIN1881805
Trnka, Burlingame et al.: Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of... in Molecular & cellular proteomics : MCP 2010
Show all 5 Pubmed References
Human Polyclonal SHC1 Primary Antibody for WB - ABIN2801945
Migliaccio, Mele, Salcini, Pelicci, Lai, Superti-Furga, Pawson, Di Fiore, Lanfrancone, Pelicci: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. in The EMBO journal 1997
Show all 3 Pubmed References
Human Monoclonal SHC1 Primary Antibody for IF, IHC - ABIN2731989
Bhat, Baba, Adams, Khanday: Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells. in British journal of cancer 2014
Characterization of bioenergetic parameters and reactive oxygen species production showed that the cellular model of Leigh syndrome is described by increased intracellular oxidative stress and oxidative damage to DNA and proteins, which correlate with increased p66Shc phosphorylation at Ser36.
A positive relationship between the p66Shc expression and oxidative stress was found. p66Shc and oxidative stress were significant predictors of the degree of tubular damage.
Adeno (show ADORA2A Antibodies)-X Adenoviral System 3 can be used to efficiently construct recombinant adenovirus containing p66Shc gene, and the Adeno (show ADORA2A Antibodies)-X can inhibit the proliferation of MCF-7 cells by inducing cell cycle arrest at the G2/M phase
STAT4 (show STAT4 Antibodies) is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells
Isoform b of DDR1 (show DDR1 Antibodies) is responsible for collagen I-induced up-regulation of N-cadherin (show CDH2 Antibodies) and tyrosine 513 of DDR1b is necessary.
NIC (show NCSTN Antibodies) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (show NCSTN Antibodies)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (show GABPA Antibodies)/heme oxygenase-1 (HO-1 (show HMOX1 Antibodies)) axis
The results show that the interaction between STS-1 (show STS1 Antibodies) and ShcA is regulated in response to EGF receptor (show EGFR Antibodies) activation.
Nox4 (show NOX4 Antibodies)-derived H2O2 in part activates Nox2 (show CYBB Antibodies) to increase mitochondrial ROS (show ROS1 Antibodies) via pSer36-p66Shc, thereby enhancing VEGFR2 (show KDR Antibodies) signaling and angiogenesis in endothelial cells.
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (show POLD3 Antibodies)CA (p66) activation invol (show SIGLEC1 Antibodies)ving Ser(139) and a motif surroun (show SIGLEC1 Antibodies)ding Ser(213).
Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (show POLD3 Antibodies) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.
Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.
ShcA is required for Wnt-5a (show WNT5A Antibodies)/Ror2 (show ROR2 Antibodies) mediated upregulation of xPAPC (show PCDH8 Antibodies), which demonstrates the functional relevance of this interaction.
Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (show CAT Antibodies).
p66shc, but not p53 (show TP53 Antibodies), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.
p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos
These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.
Data show that 66-kDa Src (show SRC Antibodies) homology 2 domain-containing protein (p66Shc) is acetylated under high glucose conditions and is deacetylated by Sirtuin1 (show SIRT1 Antibodies) lysine deacetylase (Sirt1 (show SIRT1 Antibodies)) on lysine 81.
P66Shc, a key regulator of metabolism and mitochondrial ROS (show ROS1 Antibodies) production, is dysregulated by mouse embryo culture
The results indicate that Shc proteins should be considered as potential targets for developing interventions to mitigate weight gain on high-fat diet by stimulating energy expenditure.
Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (show MLXIP Antibodies)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (show SIRT1 Antibodies).
p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (show POLD3 Antibodies) activation involving Ser (show SIGLEC1 Antibodies)(139) and a motif surrounding Ser (show SIGLEC1 Antibodies)(213).
JNK1 (show MAPK8 Antibodies)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.
Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (show HADHB Antibodies) ACAA2 (show ACAA2 Antibodies), to which p46Shc binds directly and with a strong affinity.
In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (show INS Antibodies) resistance.
p53 (show TP53 Antibodies)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
SHC (Src homology 2 domain containing) transforming protein 1
, Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
, squalene--hopene cyclase
, SH2 domain protein C1
, SHC-transforming protein 1
, src homology 2 domain-containing-transforming protein C1
, SHC-transforming protein 1-like
, SHC (Src homology 2 domain-containing) transforming protein 1
, SHC-transforming protein 3
, SHC-transforming protein A
, src homology 2 domain-containing transforming protein C1
, src homology collagen
, adaptor protein SHC