Browse our anti-SHC1 (SHC1) Antibodies

Human SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Characterization of bioenergetic parameters and reactive oxygen species production showed that the cellular model of Leigh syndrome is described by increased intracellular oxidative stress and oxidative damage to DNA and proteins, which correlate with increased p66Shc phosphorylation at Ser36.

2. A positive relationship between the p66Shc expression and oxidative stress was found. p66Shc and oxidative stress were significant predictors of the degree of tubular damage.

3. Adeno (show ADORA2A Antibodies)-X Adenoviral System 3 can be used to efficiently construct recombinant adenovirus containing p66Shc gene, and the Adeno (show ADORA2A Antibodies)-X can inhibit the proliferation of MCF-7 cells by inducing cell cycle arrest at the G2/M phase

4. STAT4 (show STAT4 Antibodies) is a novel transcriptional regulator of p66Shc in normal and chronic lymphocytic leukemia B cells

5. Isoform b of DDR1 (show DDR1 Antibodies) is responsible for collagen I-induced up-regulation of N-cadherin (show CDH2 Antibodies) and tyrosine 513 of DDR1b is necessary.

6. NIC (show NCSTN Antibodies) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (show NCSTN Antibodies)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (show GABPA Antibodies)/heme oxygenase-1 (HO-1 (show HMOX1 Antibodies)) axis

7. The results show that the interaction between STS-1 (show STS1 Antibodies) and ShcA is regulated in response to EGF receptor (show EGFR Antibodies) activation.

8. Nox4 (show NOX4 Antibodies)-derived H2O2 in part activates Nox2 (show CYBB Antibodies) to increase mitochondrial ROS (show ROS1 Antibodies) via pSer36-p66Shc, thereby enhancing VEGFR2 (show KDR Antibodies) signaling and angiogenesis in endothelial cells.

9. Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (show POLD3 Antibodies)CA (p66) activation invol (show SIGLEC1 Antibodies)ving Ser(139) and a motif surroun (show SIGLEC1 Antibodies)ding Ser(213).

10. Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (show POLD3 Antibodies) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.

Zebrafish SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.

Xenopus laevis SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. ShcA is required for Wnt-5a (show WNT5A Antibodies)/Ror2 (show ROR2 Antibodies) mediated upregulation of xPAPC (show PCDH8 Antibodies), which demonstrates the functional relevance of this interaction.

Cow (Bovine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (show CAT Antibodies).

2. p66shc, but not p53 (show TP53 Antibodies), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.

3. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos

4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.

Mouse (Murine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) interaction partners

1. Data show that 66-kDa Src (show SRC Antibodies) homology 2 domain-containing protein (p66Shc) is acetylated under high glucose conditions and is deacetylated by Sirtuin1 (show SIRT1 Antibodies) lysine deacetylase (Sirt1 (show SIRT1 Antibodies)) on lysine 81.

2. P66Shc, a key regulator of metabolism and mitochondrial ROS (show ROS1 Antibodies) production, is dysregulated by mouse embryo culture

3. The results indicate that Shc proteins should be considered as potential targets for developing interventions to mitigate weight gain on high-fat diet by stimulating energy expenditure.

4. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (show MLXIP Antibodies)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (show SIRT1 Antibodies).

5. p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.

6. Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (show POLD3 Antibodies) activation involving Ser (show SIGLEC1 Antibodies)(139) and a motif surrounding Ser (show SIGLEC1 Antibodies)(213).

7. JNK1 (show MAPK8 Antibodies)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

8. Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (show HADHB Antibodies) ACAA2 (show ACAA2 Antibodies), to which p46Shc binds directly and with a strong affinity.

9. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (show INS Antibodies) resistance.

10. p53 (show TP53 Antibodies)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity