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TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples. TrkA expression was independent of histologic subtypes but associated with lymph node metastasis, suggesting the involvement of TrkA in tumor invasiveness. Nerves in the tumor microenvironment were positive for TrkA.
phenotypes, as well as both recurrent and novel mutations in NTRK1 in 2 Chinese patients with CIPA
we conclude that complete abolition of TRKA kinase activity is not the only pathogenic mechanism underlying HSAN (show SPTLC1 Proteins) IV.
Nine patients have been reported from nine unrelated families with hereditary sensory and autonomic neuropathy IV due to various mutations in NTRK1, five of which are novel.
Data suggest that kinase domains of neurotrophin (show BDNF Proteins) receptor isoforms, TRKA, TRKB (show NTRK2 Proteins), and TRKC (show NTRK3 Proteins), exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
analysis of NTRK1 transcripts in peripheral blood cells of the patient revealed an influence of the variant on mRNA splicing. The C>A transversion generated a novel splice-site, which led to the incorporation of 10 intronic bases into the NTRK1 mRNA and consequently to a non-functional gene product.
A novel nonsense mutation and a known splice-site mutation were detected in NTRK1 in two siblings and were shown to be associated with congenital insensitivity to pain with anhidrosis.
NT3 (show NTF3 Proteins) upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt (show AKT1 Proteins)-cyclin D1 (show CCND1 Proteins) cascade.
NTRK1 gene fusion in spitzoid neoplasms results in tumors with Kamino bodies and were typically arranged in smaller nests with smaller predominantly spindle-shaped cells, occasionally forming rosettes.
Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA and TrkB (show NTRK2 Proteins) signaling pathways.
Foretinib protected neurons by suppressing both known degenerative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members.
nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression.
retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons.
These findings suggest that by interacting with PlexA4 (show PLXNA4 Proteins), TrkA plays a crucial role in redirecting local Sema3A (show SEMA3A Proteins) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (show GRIA2 Proteins) localization and patterning.
proposal that KIF1A (show KIF1A Proteins) is essential for the survival and function of sensory neurons because of the TrkA transport and its synergistic support of the NGF (show NGFB Proteins)/TrkA/PI3K signaling pathway
As a result, overexpression of PTP (show SLC25A3 Proteins)-MEG2 (show PTPN9 Proteins) down-regulates NGF (show NGFB Proteins)/TrkA signaling and blocks neurite outgrowth and differentiation
TrkA misfolding and aggregation induced by some Insensitivity to Pain with Anhidrosis mutations disrupt the autophagy homeostasis causing neurodegeneration.
USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2 (show NEDD4L Proteins)-dependent Kv7.2 (show KCNQ2 Proteins)/3 channel regulation.
functional PAP (show ASAP1 Proteins)(thorn) neurons are essential for the analgesic effect, which is mediated by NGF (show NGFB Proteins)-trkA signaling.
By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB (show NTRK2 Proteins)-receptors in cells and fibers of granular and molecular layers. TrkC (show NTRK3 Proteins) was faintly detected
TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive.
report describing differential expression of proteins and mRNA for NGF (show NGFB Proteins) and its cognate receptors, NTRK1 and NGFR (show NGFR Proteins), in the male sex organs of rabbits
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
, TRK1-transforming tyrosine kinase protein
, high affinity nerve growth factor receptor
, tropomyosin-related kinase A
, tyrosine kinase receptor A
, TrkA neurotrophin receptor
, slow nerve growth factor receptor
, trkA proto-oncogene receptor
, neurotrophic tyrosine kinase receptor type 1
, tropomyosin receptor kinase
, neurotrophic tyrosine kinase, receptor, type 1
, high affinity nerve growth factor receptor-like