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These results suggest that polymorphisms in NTRK1 play an important role in pain sensitivity in young Han Chinese women
We developed a comprehensive model of acquired resistance to NTRK inhibitors in cancer with NTRK1 rearrangement and identified cabozantinib as a therapeutic strategy to overcome the resistance
TrkA plays an important role in the pathogenesis of NPM-ALK(+) T-cell lymphoma.
Results show frequent BRCA2 (show BRCA2 Proteins), EGFR (show EGFR Proteins), and NTRK1/2/3 mutations in mismatch repair-deficient colorectal cancers , sugggesting personalized medicine strategies to treat the patients with advanced disease who may have no remaining treatment options
novel deletional mutation has enriched the spectrum of NTRK1 mutations
This study identify four novel NTRK1 mutations (IVS14+3A>T, p.Ser235*, p.Asp596Asn, and p.Leu784Serfs*79) and demonstrate that they are pathologic mutations using an mRNA splicing assay and an NTRK autophosphorylation assay.
Report a novel mechanism for the TRAIL-induced apoptosis of TrkAIII expressing NB cells that depends upon SHP (show LAMC1 Proteins)/Src (show SRC Proteins)-mediated crosstalk between the TRAIL-receptor signaling pathway and TrkAIII.
This show evidence of variation in plasmatic monocytic TrkA expression during the progression of dementia.
TrkA was detected in 20% of thyroid cancers, compared with none of the benign samples. TrkA expression was independent of histologic subtypes but associated with lymph node metastasis, suggesting the involvement of TrkA in tumor invasiveness. Nerves in the tumor microenvironment were positive for TrkA.
phenotypes, as well as both recurrent and novel mutations in NTRK1 in 2 Chinese patients with CIPA
The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 (show ULK1 Proteins) repression may result in limited NGF (show NGFB Proteins)/TrkA retrograde signaling within activated Rab5 (show RAB5A Proteins) endosomes, explaining the progressive failure of neurite outgrowth and survival.
antibodies raised against NGF (show NGFB Proteins), TrkA, and p75 (show NGFR Proteins) (also known as CD271 (show NGFR Proteins)) were used to explore the expression of these antigens in the non-decalcified young mouse femur.
these findings demonstrate that communication between osteoblasts and sensory nerves through NGF (show NGFB Proteins)-TrkA signaling is essential for load-induced bone formation in mice.
Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA and TrkB (show NTRK2 Proteins) signaling pathways.
Foretinib protected neurons by suppressing both known degenerative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members.
nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression.
retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons.
These findings suggest that by interacting with PlexA4 (show PLXNA4 Proteins), TrkA plays a crucial role in redirecting local Sema3A (show SEMA3A Proteins) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (show GRIA2 Proteins) localization and patterning.
proposal that KIF1A (show KIF1A Proteins) is essential for the survival and function of sensory neurons because of the TrkA transport and its synergistic support of the NGF (show NGFB Proteins)/TrkA/PI3K signaling pathway
As a result, overexpression of PTP (show SLC25A3 Proteins)-MEG2 (show PTPN9 Proteins) down-regulates NGF (show NGFB Proteins)/TrkA signaling and blocks neurite outgrowth and differentiation
By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB (show NTRK2 Proteins)-receptors in cells and fibers of granular and molecular layers. TrkC (show NTRK3 Proteins) was faintly detected
TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive.
report describing differential expression of proteins and mRNA for NGF (show NGFB Proteins) and its cognate receptors, NTRK1 and NGFR (show NGFR Proteins), in the male sex organs of rabbits
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
, TRK1-transforming tyrosine kinase protein
, high affinity nerve growth factor receptor
, tropomyosin-related kinase A
, tyrosine kinase receptor A
, TrkA neurotrophin receptor
, slow nerve growth factor receptor
, trkA proto-oncogene receptor
, neurotrophic tyrosine kinase receptor type 1
, tropomyosin receptor kinase
, neurotrophic tyrosine kinase, receptor, type 1
, high affinity nerve growth factor receptor-like