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anti-Human VEGFC Antibodies:
anti-Mouse (Murine) VEGFC Antibodies:
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Human Polyclonal VEGFC Primary Antibody for IHC (fro), IHC (p) - ABIN258871
Zampell, Yan, Avraham, Daluvoy, Weitman, Mehrara: HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Show all 8 Pubmed References
Human Polyclonal VEGFC Primary Antibody for IP, ELISA - ABIN541859
Krishnan, Kirkin, Steffen, Hegen, Weih, Tomarev, Wilting, Sleeman: Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. in Cancer research 2003
Show all 3 Pubmed References
Human Polyclonal VEGFC Primary Antibody for IF (p), IHC (p) - ABIN731723
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Show all 3 Pubmed References
Human Polyclonal VEGFC Primary Antibody for FACS, IHC (p) - ABIN650694
Yan, Zhu, Yu, Ji, Zhang, Ji, Yan, Chen, Liu, Yin, Lin: Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. in World journal of gastroenterology : WJG 2004
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Human Monoclonal VEGFC Primary Antibody for ICC, IHC (fro) - ABIN438679
Moussai, Mitsui, Pettersen, Pierson, Shah, Suárez-Fariñas, Cardinale, Bluth, Krueger, Carucci: The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. in The Journal of investigative dermatology 2010
Show all 2 Pubmed References
Rat (Rattus) Polyclonal VEGFC Primary Antibody for IP, ELISA - ABIN1589911
Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. in PLoS ONE 2014
Human Polyclonal VEGFC Primary Antibody for ELISA, IHC - ABIN6265969
Bai, Wang, Han, Xie, Ji, Yin, Chen, Wang, Jiang, Qi, Jiang: BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo. in Molecular carcinogenesis 2017
These findings thus underscore a role for posterior cardinal (show CARD8 Antibodies) vein and VegfC in patterning the head kidney prior to organ assembly and function.
Vegfc acts through ERK (show MAPK1 Antibodies) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (show MT2 Antibodies) in angiogenesis, but also propose Mt2 (show MT2 Antibodies) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (show MAFB Antibodies) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (show CCBE1 Antibodies), and Vegfc-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Antibodies) overexpression. Moreover, Vegfc- and Vegfr3 (show FLT4 Antibodies)-dependent Erk (show MAPK1 Antibodies) signaling is impaired in the absence of Ccbe1 (show CCBE1 Antibodies).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (show FLT4 Antibodies) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
VEGF-C and VEGF (show VEGFA Antibodies)-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (show RLN1 Antibodies) and recombinant human relaxin-2 (show RLN1 Antibodies) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
Concomitant high expression of survivin and VEGF-C is closely associated with LNM status of PTC (show F9 Antibodies) patients, which suggests their cooperation in the metastatic process.
TNFSF15 (show TNFSF15 Antibodies), a cytokine mainly produced by blood endothelial cells, facilitates tumor lymphangiogenesis by upregulating VEGFC expression in A549 cells.
SPARC (show SPARC Antibodies) expression was inversely associated with the degree of malignancy and it had a negative correlation with VEGF-C and VEGF-D (show Figf Antibodies) expression. Results suggest SPARC (show SPARC Antibodies) might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D (show Figf Antibodies).
VEGF-A/VEGF (show VEGFA Antibodies)-C analysis showed higher positivity in metastatic nodes and higher positivity in the surrounding negative nodes from positive cases in comparison with nonmetastatic patients.
this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C and HGF (show HGF Antibodies)
Lymphangiogenesis during tubulointerstitial fib (show CTGF Antibodies)rosis to be associated with increased expression of CTGF and VEGF-C in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C production in HK-2 cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C upregulation.
Smad4 (show SMAD4 Antibodies) expression negatively correlated with VEGF-A (show VEGFA Antibodies) and VEGF-C in colon cancer
study is the first to describe the mechanism of leptin (show LEP Antibodies)-promoted lymphangiogenesis by upregulating VEGF-C expression in chondrosarcomas.
Retroperitoneal tumour progression in EOC patients is associated with high VEGF-C expression.
Mechanistic investigations indicated that BDNF (show BDNF Antibodies) facilitated VEGF-C-dependent lymphangiogenesis through the MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway.
As shown in mouse model of kidney fibrosis CTGF (show CTGF Antibodies) is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C.
Fluid shear stress regulates vascular remodeling via VEGFR-3 (show FLT4 Antibodies) activation, independently of its ligand, VEGF-C, in the uterus during pregnancy.
A novel heparin conjugate (LHbisD4) is shown to prevent lymphangiogenesis by blocking the vascular endothelial growth factor C (VEGF-C) induced signaling pathway.
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (show Adamts2 Antibodies) and CCBE1 (show CCBE1 Antibodies) spatially and temporally patterns developing lymphatics, and one in which VEGFD (show Figf Antibodies) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (show IL6 Antibodies)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (show SRC Antibodies)-FAK (show PTK2 Antibodies)-STAT3 (show STAT3 Antibodies) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (show HPSE Antibodies)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 Antibodies)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (show SDC1 Antibodies)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (show MT1X Antibodies) metallothioneins (MTs (show NEU2 Antibodies)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (show TGFB1 Antibodies) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184