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hippocampal glucose hypometabolism elevates ASIC2a expression by suppressing TFCP2 expression, which further enhances the intrinsic excitability of CA1 pyramidal neurons and increases seizure susceptibility in patients with temporal lobe epilepsy.
Study shows that ASIC2 promotes metastasis of colorectal cancer (CRC) cells by activating the calcineurin/NFAT1 pathway under acidosis and high expression of ASIC2 predicts poor outcomes of patients with CRC.
The authors finally confirmed that the ASIC2b isoform is delivered to the cell surface from the endoplasmic reticulum by forming heteromers with ASIC2a isoform, and that the N-terminal region of ASIC2a is additionally required for the ASIC2a-dependent membrane targeting of ASIC2b.
The ASIC2 are involved in fear behaviours, learning and memory functions, and pain sensation.
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2, and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
ASICs may enhance susceptibility to epileptogenesis in the piriform cortex.
results demonstrate the occurrence of ASIC2 and TrkB in the human intervertebral disc (IVD), and the increased expression of both in pathological IVD suggest their involvement in IVD degeneration
distribution of ASIC2 in the human cutaneous mechanosensory system and suggest the involvement of ASIC2 in mechanosensation
This study suggests that ASIC2 may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder.
Combinatorial analysis suggests a model of random mixing of ASIC1a and ASIC2a subunits to yield both 2:1 and 1:2 ASIC1a:ASIC2a heteromers together with ASIC1a and ASIC2a homomers.
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
ACCN1 might be one of numerous susceptibility genes for panic disorder.
these results indicate that ACCN1 gene is a potential candidate for response to lithium treatment that would serve as a genetic marker of lithium efficacy for bipolar disorder patients.
These results demonstrate for the first time the differential distribution of ASIC1 and ASIC2 in human rapidly adapting low-threshold mechanoreceptors, and suggest specific roles of both proteins in mechanotransduction.
Application of these methods allowed us to find a significant association between MS and the SNP rs28936 located in the 3' UTR segment of ACCN1 with p = 0.0004 (p = 0.002, after adjusting for multiple testing)
the ASIC2a subtype consists of intracellular amino and carboxyl termini and two transmembrane domains connected by a large extracellular loop
ASIC2 surface expression inhibits the amiloride-sensitive current and migration of glioma cells
AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity
This work provides a mechanism explaining how defects in parkin-mediated PICK1 monoubiquitination could enhance ASIC activity and thereby promote neurodegeneration in Parkinson's disease.
Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.
ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells.
the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.
ASIC2 deletion significantly protected the mouse brain from ischemic damage in vivo.
Studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels.
differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b, was investigated.
These data identify the LL motifs as a negative regulator of ASIC2a trafficking and function, and suggest novel regulatory mechanisms in acid signaling.
ASIC2 contributes to transduction of the renal myogenic response and has a protective role against renal injury and hypertension.
These results lend support to an emerging role of ASIC2 in the targeting of ASICs to surface membranes, and allows for interaction with PSD-95 to regulate these processes.
A previously unknown postsynaptic current during neurotransmission mediated by ASIC1A and ASIC2 is well positioned to regulate synapse structure and function.
ASIC2 knockout mice showed less sensitization to challenge cocaine when compared to wild-type.
Currents from ASIC1a(-/-) muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2(-/-) showed diminished potentiation by zinc, and currents from ASIC3(-/-) displayed slower desensitization than those from wild-type.
Anions modulate a variety of acid-sensing ion channel properties and are dependent on subunit composition. The mechanism of modulation for ASIC2a and -3 is distinct from that of ASIC1a.
loss of ACCN1 function does not modify dental fluorosis severity in mice
Therefore, PICK1 interacts with BNaC/ASIC channels and may regulate their subcellular distribution or function in both peripheral and central neurons
These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons.
Photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a(ASIC2a) and ASIC2b; ASIC2 knock-out mice are more sensitive to light-induced retinal degeneration.
findings indicate that the absolute and relative amounts of ASIC subunits (ASIC1 & ASIC2) determine the amplitude and properties of hippocampal H(+)-gated currents and therefore may contribute to normal physiology and pathophysiology.
ASIC2b has a role in regulation of ASIC3 via the partner protein PICK-1
results indicate that ASIC2 is not required for acid taste in mice, and that if a universal mammalian acid taste transduction mechanism exists, it likely uses other acid-sensitive receptors or ion channels
our data do not support a role of ASIC2 in cutaneous mechanosensation and visceral mechanonociception.
These results are the first demonstration that ASIC2 and ASIC4 are expressed in the adult zebrafish retina
The ASIC2 expression in this location might be related to detection of aquatic environment pH variations or to detection of water movement through the nasal cavity.
The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride.
Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN differential properties; ACCN1 and ACCN3 genes have an ubiquitous expression but ACCN1 is more highly expressed in the spinal cord.
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
acid-sensing ion channel 2
, amiloride-sensitive cation channel 1, neuronal
, brain sodium channel 1
, mammalian degenerin homolog
, neuronal amiloride-sensitive cation channel 1
, amiloride-sensitive brain sodium channel
, amiloride-sensitive cation channel 1, neuronal (degenerin)
, amiloride-sensitive brain sodium channel 2
, acid-sensing (proton-gated) ion channel 2