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PMCA2 regulates breast cancer cell proliferation and sensitivity to doxorubicin in basal cell carcinoma.
Cytoskeleton dynamics regulates plasma membrane PMCA2 activity.
Data show that ATPase (show DNAH8 Antibodies), calcium transporting, plasma membrane 2 protein (PMCA2) silencing augmented B-cell leukemia 2 family proteins (Bcl-2 (show BCL2 Antibodies)) inhibitor ABT-263-mediated MDA-MB-231 breast cancer cell death.
NHERF1 (show SLC9A3R1 Antibodies) acts with PMCA2 to regulate HER2 (show ERBB2 Antibodies) signaling and membrane retention in breast cancers
PMCA2 interacts with HER2 in specific actin-rich membrane domains.
PMCA2b resulted in rapid and highly PMCA abundance-sensitive clearance of store-operated Ca2 (show CA2 Antibodies)+ entry-mediated Ca2 (show CA2 Antibodies)+ transients.
SERCA (show ATP2A3 Antibodies) and PMCA pump activities are strongly affected by the localization of F508del-CFTR (show CFTR Antibodies) protein.
ATP2B2 might play a role in the etiology of autism in Chinese Han population.
G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase (show DNAH8 Antibodies) of the stereocilia are associated with deafness. (Review)
The human mutant of PMCA2 exacerbated the deafness produced by a cadherin 23 mutation. The human mutant failed to impair the Ca(2 (show CA2 Antibodies)+) ejection by the pump.
Early growth response protein 1 (show EGR1 Antibodies) regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump (show CA-P60A Antibodies) in the brain and auditory system
These findings indicate a novel role for PMCA2 in modality- and sex-dependent pain responsiveness. Female-specific molecular changes potentially account for the altered pain responses
These results indicate that a significant fraction of the postsynaptic NMDAR (show GRIN1 Antibodies) current is reliant on a perisynaptic extracellular alkaline shift generated by the PMCA.
Our results demonstrate that PMCA2 activity is an important regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth
This study further resolves the interaction between Atp2b2 and Cdh23 (show CDH23 Antibodies) in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction.
loss of PMCA2 adversely influences the function and organisation of Purkinje neuron synaptic inhibition
The Atp2b2 (Deaf13) mutation leads to a p. R561S substitution in the catalytic core. Mice homozygous for these mutations display profound hearing loss.
Amplitude of depolarization and AMPAR-mediated Ca(2 (show CA2 Antibodies)+) transients are significantly higher in cultured PMCA2(+/-) than in PMCA2(+/+) Purkinje cells due to increased Ca(2 (show CA2 Antibodies)+) influx.
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
plasma membrane Ca(2+)-ATPase
, plasma membrane Ca2+ pump 2
, plasma membrane calcium ATPase
, plasma membrane calcium pump
, plasma membrane calcium-transporting ATPase 2
, ATPase, Ca++ transporting, plasma membrane 4
, plasma membrane calcium ATPase 2
, ATPase, Ca++ transporting, plasma membrane 2
, plasma membrane calcium-transporting ATPase 4
, deaf waddler
, ATPase isoform 2 Na+K+ transporting beta polypeptide 2
, ATPase isoform 2, Na+K+ transporting, beta polypeptide 2
, plasma membrane Ca++-ATPase
, plasma membrane calcium-transporting ATPase 2-like