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the Src (show SRC ELISA Kits) tyrosine kinase (show TXK ELISA Kits) Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance.
we provide evidence for involvement of HCK (show HCK ELISA Kits) and FGR in FCRL4 (show FCRL4 ELISA Kits)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 ELISA Kits) molecule.
Data indicate that combined treatment using SFK (LYN (show LYN ELISA Kits), HCK (show HCK ELISA Kits), or FGR) and c-KIT (show KIT ELISA Kits) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 ELISA Kits) activity and enhancing targeting of acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) stem cells.
Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target
Recruitment of the coactivator, SRC2 (show NCOA2 ELISA Kits), is coupled to cooperative DNA binding by the progesterone receptor (show PGR ELISA Kits).
the Hck (show HCK ELISA Kits), Fgr and Lyn (show LYN ELISA Kits) kinases are also necessary for amastigote uptake by macrophages. Src (show SRC ELISA Kits)-mediated Arg activation is required for efficient uptake.
Data indicate that Src (show SRC ELISA Kits)-Family Kinases Hck (show HCK ELISA Kits) and Fgr regulate cytokine secretion by macrophages.
Fgr is not only are progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
Ablation of Fgr abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.
The Src (show SRC ELISA Kits) family kinases Hck (show HCK ELISA Kits), Fgr, and Lyn (show LYN ELISA Kits) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Despite possessing enhanced killing, alveolar macrophage Fgr/Hck (show HCK ELISA Kits)/Lyn (show LYN ELISA Kits)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-
interaction of MIST (show CLNK ELISA Kits) with Fgr, mediated by the C-terminal proline-rich region of MIST (show CLNK ELISA Kits) and the SH3 domain (show ITSN1 ELISA Kits) of Fgr, was required for the suppression of NK-cell receptor (show KLRD1 ELISA Kits)-induced IFN-gamma (show IFNG ELISA Kits) production
Fgr plays no role in chemoattractant-induced, inside-out beta 2 integrin activation of neutrophils but regulates their outside-in, signaling-dependent sustained adhesion.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, basic fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, tyrosine-protein kinase Fgr
, proto-oncogene tyrosine-protein kinase FGR
, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
, tyrosine-protein kinase Fgr-like
, Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
, proto-oncogene tyrosine-protein kinase Fgr
, c-fgr protooncogene
, c-src-2 proto-oncogene
, p55-c-fgr protein
, v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog