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Results show that rs4660468 T allele of KCNQ4 involves with a higher risk of noise-induced hearing loss (NIHL) and it could be one biomarker of susceptibility for Chinese noise exposed workers. Furthermore, genetic variations of KCNQ4 and noise exposure jointly contribute to the NIHL risks by gene-environment interactions.
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KCNQ4 gene polymorphisms associated with susceptibility to noise-induced hearing loss.
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mutations in KCNQ4 gene are unlikely to be a major causative factor of ADNSHL in our studied patients from West Bengal, India, pointing to other genes might be responsible for ADNSHL in our studied patients
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The fundamental processes that dictate Kv7.4 activity.
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A novel KCNQ4 mutation, c.887 G > A (p.G296D), was identified in all five affected members in a Chinese family with autosomal dominant non-syndromic deafness 2. This mutation leads to a glycine-to-aspartic acid substitution at position 296 in the pore region of the KCNQ4 channel.
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Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation.
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Gene and protein expression analyses show the predominance of KV7.4 channels over the other KV7 channel subtypes in human detrusor.
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Kv7.4 channels are present and functional in cardiac mitochondria; their activation exerts a significant cardioprotective role
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analysis of mechanistic insights into the critical roles of Ca(2+)/CaM regulation of the Kv7.4 channel under physiological and pathological conditions
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Interaction between G-protein betagamma subunits and Kv7.4 is crucial for channel responses to membrane voltage.
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genotype-phenotype correlation is analogous to that in KCNQ1 which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype
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This study provides evidence that mouse Kv7 channels may contribute differently to regulating the functional properties of cerebral and coronary arteries.
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The study identified a novel KCNQ4 mutation in a five generation Chinese family and a known KCNQ4 mutation in a six generation Chinese family.
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These findings suggest a protective role for Kv7.4 channels in the pulmonary circulation, limiting its reactivity to pressor agents and preventing hypoxia-induced pulmonary hypertension.
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Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family.
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Kv7.4 currents are inhibited in a CB1 pathway repressed by endocannabinoid 2-AG
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In-frame deletion in KCNQ4 P-loop was identified in family members with autosomal dominant sensorineural hearing loss.
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Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
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decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2
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A new typical audiogram configuration characterized by mid-frequency predominant hearing loss caused by the KCNQ4 V230E mutation.
