Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human PCDH15 Antibodies:
anti-Mouse (Murine) PCDH15 Antibodies:
anti-Rat (Rattus) PCDH15 Antibodies:
Go to our pre-filtered search.
Novel 4658delT PCDH15 mutation was identified in a family with nonsyndromic hearing loss.
PCDH15 polymorphism is associated with extraversion.
Results present structures of a protocadherin-15 fragment featuring a non-canonical linker region that exhibits increased flexibility without compromising mechanical strength.
This study confirms that genetic variations in PCDH15 modify the susceptibility to noise-induced hearing loss development in humans.
Results uncovered a novel interaction between MYO3A (show MYO3A Antibodies) and PCDH15 shedding new light on the function of myosin IIIA (show MYO3A Antibodies) at stereocilia tips.
no statistically significant association between any rare, heterozygous PCDH15 point variants and schizophrenia or autism spectrum disorders was found
PCDH15 p.Asp1010Gly variant probably modified the phenotypic expression of the 7511T>C mutation in MT-TS1
The novel homozygous mutation in a family segregating non-syndromic hearing loss family supports previous reported observations that PCDH15 does not only causes Usher syndrome type 1F, but also DFNB23.
PCDH15 or DFNB59 (show DFNB59 Antibodies) variants are associated with poor CI performance, yet children with PCDH15 or DFNB59 (show DFNB59 Antibodies) variants might show clinical features indistinguishable from those of other typical pediatric cochlear implant recipients.
PCDH15 has several alternate cytoplasmic domain exons and differentially spliced isoforms may function redundantly
a modified ciliary transport pathway used for Pcdh15 transport into the cilium of the inner ear hair cell and coordinated by FGFR1 (show FGFR1 Antibodies) activity.
Many GABAergic interneurons, from their generation in the medial ganglionic eminence up to their settlement in the auditory cortex, express two cadherin-related (cdhr) proteins, cdhr23 and cdhr15, that form the hair bundle tip links gating the mechanoelectrical transduction channels.
results demonstrate that alternative heterophilic tip-link structures form stable protein-protein interactions in vitro and suggest that homophilic PCDH15-PCDH15 tip links form through the interaction of additional EC repeats
interactions of wild type (WT) and mutant variants of N-terminal fragments (EC1+2) of cadherin-23 (show CDH23 Antibodies) and protocadherin-15, two proteins essential for inner-ear mechanotransduction, are reported.
data show that LHFPL5 (show LHFPL5 Antibodies) is already present in the MET apparatus at P0 but requires PCDH15 at P3 to remain there. Shaft/ankle link localisation suggests it interacts with link proteins other than PCDH15
Through an interaction with PIST (show GOPC Antibodies), PCDH15 is retained in the trans-Golgi network and its expression is reduced in the plasma membrane.
Absence of Pcdh15-CD2 (show CCND2 Antibodies) isoform results in the loss of tip-links in mature auditory hair cells.
Pcdh15 as a determinant of SERT (show SLC6A4 Antibodies) protein expression and 5-HT (show DDC Antibodies) homeostasis.
the involvement of the gene Pcdh15 in auditory function
These results offer new insights into the interaction between PCDH15 and CDH23 (show CDH23 Antibodies) and help explain the etiology of human deafness linked to mutations in the tip-link interface.
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
cadherin-related family member 15
, Ames waltzer
, protocadherin 15 CD2
, protocadherin 15 CD3 isoform
, protocadherin 15