PCDH15 antibody (N-Term)

Catalog No. ABIN2784074

This Rabbit Polyclonal antibody specifically detects PCDH15 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Dog and Rabbit.

Quick Overview for PCDH15 antibody (N-Term) (ABIN2784074)

Target: PCDH15 (Protocadherin-15 (PCDH15))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDH15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCDH15 Antibody

Binding Specificity: N-Term

Purpose: PCDH15 Antibody - N-terminal region

Sequence: HSIVVQVQCI NKKVGTIIYH EVRIVVRDRN DNSPTFKHES YYATVNELTP

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDH15. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDH15

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109594

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDH15

Target: PCDH15 (Protocadherin-15 (PCDH15))

Alternative Name: PCDH15

Background:

Background Information: PCDH15 is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. PCDH15 consists of a signal peptide, 11 extracellular calcium-binding domains, a transmembrane domain and a unique cytoplasmic domain. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene have been associated with hearing loss, which is consistent with its location at the Usher syndrome type 1F (USH1F) critical region on chromosome 10.

Gene Name: Protocadherin-related 15

Alternative Symbols: USH1F, CDHR15, DFNB23

Protein Name: Protocadherin 15 EMBL CAM15122.1

Molecular Weight: 80kDa

Gene ID: 65217

UniProt: A2A3E5

Pathways: Sensory Perception of Sound