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anti-Human SLC12A2 Antibodies:
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Cow (Bovine) Polyclonal SLC12A2 Primary Antibody for WB - ABIN2773831
Panet, Eliash, Atlan: Na+/K+/Cl- cotransporter activates MAP-kinase cascade downstream to protein kinase C, and upstream to MEK. in Journal of cellular physiology 2005
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Mammalian Monoclonal SLC12A2 Primary Antibody for - ABIN1304870
Antoine, Hübner, Arezzo, Hébert: A causative link between inner ear defects and long-term striatal dysfunction. in Science (New York, N.Y.) 2013
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Human Polyclonal SLC12A2 Primary Antibody for ELISA, IHC - ABIN4339820
Pawelczyk, Van Laer, Fransen, Rajkowska, Konings, Carlsson, Borg, Van Camp, Sliwinska-Kowalska: Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss. in Annals of human genetics 2009
NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1 (show CFL1 Antibodies).
This new functional assay offered a robust working model for NKCC1 in determining reliable and concordant rank orders of the test compounds supporting its sensitivity and specificity.
we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl(-) ]c via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na(+) reabsorption via expression of the epithelial Na(+) channel
NKCC1 and KCCs are coordinately regulated by L-WNK1 (show WNK1 Antibodies) isoforms.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 (show PSMB5 Antibodies) rs941718), and hematocrit (PROX1 (show PROX1 Antibodies) rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR (show EGFR Antibodies)-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.
Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia
The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.
NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.
Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.
Study showed that there is a transient dysregulation in the levels of NKCC1 and KCC2 (show SLC12A5 Antibodies) at disease onset, the time point when heightened nociceptive behaviors are most pronounced in mice with experimental autoimmune encephalomyelitis.
This study identify neuronal up-regulation of NKCC1 and its mediation by TGFbeta (show TGFB1 Antibodies), as a potential and important mechanism in the early post-traumatic seizures, and demonstrate the therapeutic potential of blocking this pathway.
Study suggests that astaxanthin may exert neuroprotection following traumatic brain injury by ameliorating AQP4 (show AQP4 Antibodies)/NKCC1-mediated cerebral edema, and NKCC1 inactivation inhibitions the upregulation of AQP4 (show AQP4 Antibodies) after traumatic brain injury.
GABAA (show GABRg1 Antibodies) receptor (GABAAR (show GABRG2 Antibodies)) and the Na(+)-K(+)-2Cl(-) cotransporter (show SLC12A1 Antibodies) (NKCC1), but not the K(+)-Cl(-) cotransporter (show SLC12A4 Antibodies) (KCC2 (show SLC12A5 Antibodies)), were expressed in the terminals of the CRH (show CRH Antibodies) neurons at the median eminence (ME). In contrast, CRH (show CRH Antibodies) neuronal somata were enriched with KCC2 (show SLC12A5 Antibodies) but not with NKCC1.
These results identify NKCC1 as a novel target for Nedd4L (show NEDD4L Antibodies)-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Antibodies)).
NKCC1 inhibition protects neurons from traumatic brain injury via regulation of the ERK (show EPHB2 Antibodies) signal pathway.
We conclude that TRPV2 (show TRPV2 Antibodies) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (show STK39 Antibodies)-activated NKCC1
KCC2 (show SLC12A5 Antibodies) expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.
GnRH (show GNRH1 Antibodies) neurons were immunopositive for NKCC1 and AE2 (show SLC4A2 Antibodies).
NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
, solute carrier family 12 member 2-like
, basolateral Na-K-Cl symporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
, solute carrier family 12 member 2
, solute carrier family 12, member 2
, basolateral NaK(2Cl) cotransporter
, sodium/potassium/chloride cotransporters
, sodium/potassium/chloride transporters