+1 877 302 8632
+1 888 205 9894 (Toll-free)

SIA1 Products

(Siamois Homeodomain 1 (SIA1))
Essential for Wnt/beta-catenin-mediated formation of the Spemann organizer and for induction of the organizer precursor, the Nieuwkoop center. Acts as a transcriptional activator, cooperating with TGFbeta signals to induce a program of organizer- specific gene expression and to generate an organizer with both head- and trunk-inducing activity. Activates the head organizer gene cer1 by acting synergistically with otx2 and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and mix-A/mix.1 to the 3x 5'-TAAT-3' element of the cer1 promoter. Required for subsequent dorsoventral axis formation in the embryo, dorsalizing ventral mesoderm and cooperating with t/bra to induce dorsal mesoderm. Also involved in neural induction, inducing the cement gland and neural tissue in overlying ectoderm. Later in development, has the second function of indirectly repressing ventral genes, probably by activating the expression of a transcriptional repressor. stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Recommended SIA1 Proteins

Cat. No.
Reactivity Xenopus tropicalis
Source Yeast
Cat. No. ABIN1620774
Quantity 1 mg
Datasheet Datasheet
Reactivity Xenopus laevis
Source Yeast
Cat. No. ABIN1642965
Quantity 1 mg
Datasheet Datasheet

Synonyms and alternative names related to SIA1

siamois homeodomain 1 L homeolog (sia1.L), sia, siamois, siamois-A, Xsia

Protein level used designations for SIA1

  • Siamois homeo domain
  • homeobox protein siamois
You are here: