Browse our anti-AFG3L2 (AFG3L2) Antibodies

Full name:: anti-AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) Antibodies (AFG3L2)

On www.antibodies-online.com are 70 AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) Antibodies from 19 different suppliers available. Additionally we are shipping AFG3L2 Proteins (3) and and many more products for this protein. A total of 78 AFG3L2 products are currently listed.

Synonyms:: 2310036I02Rik, AW260507, Emv66, MGC147390, par, SCA28, si:ch211-12e1.4, SPAX5

list all antibodies	Gene Name	GeneID	UniProt
	AFG3L2	10939	Q9Y4W6
	AFG3L2	307350
	AFG3L2	69597	Q8JZQ2
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Most Popular Reactivities for anti-AFG3L2 (AFG3L2) Antibodies

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anti-Human AFG3L2 Antibodies:

anti-Rat (Rattus) AFG3L2 Antibodies:

12 WB Antibodies

anti-Mouse (Murine) AFG3L2 Antibodies:

14 WB Antibodies

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More Antibodies against AFG3L2 Interaction Partners

Human AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) interaction partners

Deletion of AFG3L2 associated with spinocerebellar ataxia type 28 in the context of multiple genomic anomalies.
AOA2 (show SETX Antibodies) with myoclonus associated with mutations in SETX (show SETX Antibodies) and AFG3L2
This study that AFG3L2 mutations are another important cause, albeit rare, of a late-onset ataxic PEO (show POLG Antibodies) phenotype due to a disturbance of mtDNA maintenance.
StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON (show LONP1 Antibodies) protease and the inner membrane complexes of the metalloproteases AFG3L2 and AFG3L2:SPG7/paraplegin (show SPG7 Antibodies).
Here, we report on a novel AFG3L2 mutation in a patient with slowly progressive ataxia and a positive family history.
Identification of a partial AFG3L2 deletion and subsequent functional studies reveal loss of function as the most likely disease mechanism.
Both full-length and truncated COX1 (show COX1 Antibodies) proteins physically interact with AFG3L2.
These findings expand the phenotype associated with AFG3L2 mutations and suggest that AFG3L2-related disease should be considered in the differential diagnosis of spastic ataxias.
The mutations of SCA28 are associated with amino acid changes in evolutionarily conserved residues of the alleged SCA28 gene, and indicate SCA28 as the sixth recognized SCA genotype caused by point mutations.
We further confirm both the involvement of AFG3L2 gene in Spinocerebellar ataxia type 28 (SCA28) and the presence of a mutational hotspot in exons 15-16.

Mouse (Murine) AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae) (AFG3L2) interaction partners

total ablation of the m-AAA protease, by deleting both Afg3l2 and its paralogue Afg3l1, triggers progressive motor dysfunction and demyelination, owing to rapid oligodendrocyte cell death
AFG3L2 is critical to the surveillance mechanism that acts as a sensor to couple the synthesis of mitochondrial proteins with organelle fitness, thus ensuring coordinated assembly of the oxidative phosphorylation complexes from two sets of ribosomes.
defective mitochondrial protein (show COX6B2 Antibodies) synthesis, leading to early-onset fragmentation of the mitochondrial network, is a central causative factor in AFG3L2-related neurodegeneration.
These findings shed new light in the molecular mechanisms underlining neurodegeneration caused by AFG3L2 mutations.
Data show that Afg3l1 or Afg3l2 are required for maturation of newly imported paraplegin subunits after their cleavage by MPP.
AFG3L2 mutant mouse models display a marked impairment of axonal development with delayed myelination and poor axonal growth.
Spg7 (show SPG7 Antibodies) and Afg3l2 double mutants show an early-onset ataxic phenotype, indicating a role of the m-AAA (show AAAS Antibodies) proteases in cerebellar degeneration.
demonstrate that cerebellum is the neuronal tissue with the highest susceptibility to reduced Afg3l2 dosage; propose that the Afg3l2 heterozygous mouse is an excellent model to unravel the pathological cascade leading to spinocerebellar ataxia type 28

AFG3L2 Antigen Profile

Antigen Summary

This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.

Alternative names and synonyms associated with AFG3L2

AFG3 like matrix AAA peptidase subunit 2 (AFG3L2) antibody
AFG3-like protein 2 (LOC578526) antibody
AFG3 ATPase family gene 3-like 2 (S. cerevisiae) (AFG3L2) antibody
AFG3-like AAA ATPase 2 (afg3l2) antibody
AFG3-like AAA ATPase 2 L homeolog (afg3l2.L) antibody
AFG3 like matrix AAA peptidase subunit 2 (Afg3l2) antibody
AFG3-like AAA ATPase 2 (Afg3l2) antibody

2310036I02Rik antibody
AW260507 antibody
Emv66 antibody
MGC147390 antibody
par antibody
SCA28 antibody
si:ch211-12e1.4 antibody
SPAX5 antibody

Protein level used designations for AFG3L2

AFG3 ATPase family gene 3-like 2 (S. cerevisiae) , AFG3 ATPase family gene 3-like 2 , AFG3 ATPase family gene 3-like 2-like , AFG3-like protein 2-like , AFG3-like protein 2 , AFG3-like protein 2 (Paraplegin-like protein) , ATPase family gene 3, yeast , paraplegin-like protein

GENE ID	SPECIES
455507	Pan troglodytes
578526	Strongylocentrotus purpuratus
703079	Macaca mulatta
780216	Xenopus (Silurana) tropicalis
100018022	Monodelphis domestica
100367333	Saccoglossus kowalevskii
100410379	Callithrix jacchus
100448741	Pongo abelii
100484304	Ailuropoda melanoleuca
569168	Danio rerio
421036	Gallus gallus
490560	Canis lupus familiaris
515757	Bos taurus
443667	Xenopus laevis
10939	Homo sapiens
307350	Rattus norvegicus
69597	Mus musculus

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