AFG3L2 antibody (AA 531-600)

Catalog No. ABIN1386200

The Rabbit Polyclonal anti-AFG3L2 antibody is suitable to detect AFG3L2 in samples from Human. It has been validated for IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for AFG3L2 antibody (AA 531-600) (ABIN1386200)

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFG3L2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AFG3L2 Antibody

Binding Specificity: AA 531-600

Purpose: AFG3L2 Polyclonal Antibody

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AFG3L2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Alternative Name: SCA28/AFG3L2

Background:

Synonyms: AFG3 ATPase family gene 3, yeast like 2, AFG3 ATPase family gene 3 like 2 yeast, AFG3 ATPase family gene 3 like 2, AFG3 like protein 2, ATPase family gene 3 like 2, ATPase family gene 3 yeast, FLJ25993, Paraplegin like protein, SCA28, Spinocerebellar ataxia 28, AFG32_HUMAN .

Background: AFG3L2 is a multi-pass membrane metalloprotease that contains one AAA (ATPase associated with diverse cellular activities) domain, a zinc-dependent binding motif, an RNA-binding region and an ATP/GTP binding site. Localizing to the mitochondrial membrane, AFG3L2 is ubiquitously expressed with highest expression levels in skeletal muscle and heart. AFG3L2 shares 69 % similarity with the yeast Afg3 protein and 49 % similarity with Paraplegin, a protein of mitochondria that is thought to be involved in signal transduction and chaperone-like activities. In mitochondria, AFG3L2 forms a complex with Paraplegin that is believed to regulate essential protein quality control. Mutations in the gene encoding either one of these proteins can result in hereditary spastic paraplegia, a degenerative spinal cord disorder that is characterized by muscle spasms, stiffness in the legs and, in some cases, incontinence.

Pathways: Skeletal Muscle Fiber Development