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Mammalian Monoclonal CACNB2 Primary Antibody for ISt, IHC - ABIN1304588
Abiria, Colbran: CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. in Journal of neurochemistry 2010
Show all 5 Pubmed References
Human Monoclonal CACNB2 Primary Antibody for ELISA, WB - ABIN560146
Horiuchi-Hirose, Kashihara, Nakada, Kurebayashi, Shimojo, Shibazaki, Sheng, Yano, Hirose, Hongo, Sakurai, Moriizumi, Ueda, Yamada: Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. in American journal of physiology. Heart and circulatory physiology 2011
Show all 2 Pubmed References
Human Polyclonal CACNB2 Primary Antibody for ELISA, WB - ABIN4286783
Burashnikov, Pfeiffer, Barajas-Martinez, Delpón, Hu, Desai, Borggrefe, Häissaguerre, Kanter, Pollevick, Guerchicoff, Laiño, Marieb, Nademanee, Nam, Robles, Schimpf, Stapleton, Viskin, Winters et al.: Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. ... in Heart rhythm : the official journal of the Heart Rhythm Society 2010
Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2 (show CA2 Antibodies)+) overload and beta cell death.
Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3 (show MYBPC3 Antibodies)-associated familial hypertrophic cardiomyopathy
Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits
ADM (show ADM Antibodies) genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.
In the gene-based analysis, CACNB2 and CTCF (show CTCF Antibodies) showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets.
Chronic atrial fibrillation increases miR (show MLXIP Antibodies)-21 expression in human atrial myocytes and decreases I(Ca,L) density by downregulating CACNA1C (show CACNA1C Antibodies)/CACNB2 expression.
Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD (show ARSD Antibodies))-affected families, are reported.
High prevalence of CACNA2D1 (show CACNA2D1 Antibodies), SCN5A (show SCN5A Antibodies), and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.
Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population.
Genetic variations in CYP17A1 (show CYP17A1 Antibodies), CACNB2 and PLEKHA7 (show PLEKHA7 Antibodies) were related to blood pressure traits and/or hypertension in Chinese She population.
Many hormone- or neurotransmitter-activated receptors stimulate PIP2 hydrolysis and increase cytosolic Ca(2 (show CA2 Antibodies)+); thus, our findings suggest that beta2e may integrate such receptor-mediated signals to limit Cav (show CA5A Antibodies) activity.
Membrane Interaction of the beta2e Subunit of Voltage-Gated Ca(2 (show CA2 Antibodies)+) Channels
Dynamic phospholipid interaction of beta2e subunit regulates the gating of voltage-gated Ca2 (show CA2 Antibodies)+ channels.
a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane.
We conclude that phosphorylation of the C-terminal sites in Ca(v)beta(2), Ser (show SIGLEC1 Antibodies)(1928), Ser (show SIGLEC1 Antibodies)(1512), and Ser (show SIGLEC1 Antibodies)(1570) of the Ca(v)1.2 (show CACNA1C Antibodies) protein is functionally not involved in the adrenergic regulation of the murine cardiac Ca(v)1.2 (show CACNA1C Antibodies) channel.
phosphorylation event is one mechanism underlying ahnak1 (show AHNAK Antibodies)'s modulator function on Cav1.2 (show CACNA1C Antibodies) channel activity.
Mice with cardiac-specific sequestration of the beta-subunit (show POLG Antibodies) of the L-type calcium channel
preferential binding between Cacna1c (show CACNA1C Antibodies) and Cacnb2 in the heart
Ca(V)beta(2) has an essential role in regulating the abundance and properties of Ca(V)1.3 (show CACNA1D Antibodies) channels in IHCs and, thereby, is critical for IHC development and synaptic encoding of sound.
expression of various CaVbeta2 proteins may be used to adapt the properties of LTCCs to changing myocardial requirements during development
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.
calcium channel, voltage-dependent, beta 2 subunit
, L-type calcium channel beta subunit
, voltage-dependent L-type calcium channel subunit beta-2
, voltage-dependent L-type calcium channel subunit beta-2-like
, calcium channel voltage-dependent subunit beta 2
, lambert-Eaton myasthenic syndrome antigen B
, myasthenic (Lambert-Eaton) syndrome antigen B
, cardiac calcium channel beta subunit
, cardiac calcium channel beta-subunit