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Human Polyclonal UNC13B Primary Antibody for FACS, WB - ABIN652852
Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: The consensus coding sequences of human breast and colorectal cancers. ... in Science (New York, N.Y.) 2006
Show all 2 Pubmed References
A rare missense variation (V1525M) in UNC13B was identified by WES in the multiplex family; this variation was present in five of six affected individuals, but not in eight unaffected individuals or one individual of unknown disease status. Resequencing UNC13B coding regions identified five rare missense variations (T103M, M813T, P1349T, I1362T, and V1525M).
The 1-5-8-26 CaM binding motif discovered in Munc13-1 cannot be induced in the classical CaM target skMLCK, indicating unique features of the Munc13 CaM binding motif.
Munc13-1 (show UNC13A Antibodies) regulates insulin (show INS Antibodies) exocytosis
MUNC13-4 (show UNC13D Antibodies) mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway
Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34 (show RAB34 Antibodies), mediating lysosome-Golgi trafficking.
Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy.
In the bound state, the hydrophobic anchor residue of the calmodulin (CaM)-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM.
mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34 (show RAB34 Antibodies), indicating a potentially critical role for this newly described pathway in the pathogenesis of DN.
Chromaffin cell vesicle-priming by brain-specific ubMunc13 isoform 2 is calcium ion (Ca2+) dependent but independent of calmodulin binding to ubMunc13 isoform 2.
Mutating Ca(2 (show CA2 Antibodies)+)-coordinating aspartates in the C2A (show ABP Antibodies)-domain localizes Doc2B (show DOC2B Antibodies) permanently at the plasma membrane, and renders an upstream priming step Ca(2 (show CA2 Antibodies)+)-independent, whereas a separate function in downstream priming depends on SNARE (show VTI1B Antibodies)-binding, Ca(2 (show CA2 Antibodies)+)-binding to the C2B-domain of Doc2B (show DOC2B Antibodies), interaction with ubMunc13-2 and the presence of synaptotagmin-1 (show SYT1 Antibodies).
This study characterizes Munc13-1 (show UNC13A Antibodies) as a target of resveratrol and highlights the importance of dietary polyphenol in the management of neurodegenerative diseases
SIGNIFICANCE STATEMENT: DBA (show RPS19 Antibodies)/2J and C57BL/6J mice have been used to understand the genetic mechanisms controlling behaviors related to a number of psychiatric illnesses. However, the fundamental neurobiological mechanisms producing these behavioral characteristics remain unresolved. Here we identify a critical family of presynaptic proteins differentially expressed by these strains that control strain-dependent synaptic ph
Munc13-2 is recruited to synapses by the AZ protein ELKS1.
Munc13-2 plays a fundamental role in large dense-core vesicle exocytosis, but in contrast to synapses lacking Munc13s, the corresponding chromaffin cells do not exhibit a vesicle docking defect.
Data demonstrate that Munc13-1 (show UNC13A Antibodies) and DOC2B (show DOC2B Antibodies) have different effects on network activity and that by enhancing asynchronous release, DOC2B (show DOC2B Antibodies) exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts
Munc13-1 (show UNC13A Antibodies) isoform is functionaly redundant in cytotoxic T lymphocytes.
betaARs couple to a cAMP/Epac (show RAPGEF3 Antibodies)/PLC (show HSPG2 Antibodies)/Munc13-1 (show UNC13A Antibodies)/Rab3a (show RAB3A Antibodies)/RIM1a (show RIMS1 Antibodies)-dependent pathway to enhance glutamate (show GRIN1 Antibodies) release at cerebrocortical nerve terminals.
Our data establish Munc13-1 (show UNC13A Antibodies) as a major presynaptic target of Ca(2 (show CA2 Antibodies)+)-Calmodulin signaling and show that the Ca(2 (show CA2 Antibodies)+)-Calmodulin-Munc13-1 (show UNC13A Antibodies) complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.
The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials.
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
homolog of rat Munc13 (diacylglycerol-binding)
, protein unc-13 homolog B
, unc-13 homolog B (C. elegans)
, unc-13 B-like protein
, UNC-13 homolog 1
, unc-13 homolog A
, unc13 homolog 1
, protein unc-13 homolog B-like