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UNC13B antibody (Internal Region)

UNC13B Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2856793
  • Target See all UNC13B Antibodies
    UNC13B (Unc-13 Homolog B (UNC13B))
    Binding Specificity
    • 8
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 31
    • 18
    • 2
    Human
    Host
    • 40
    • 2
    • 1
    Rabbit
    Clonality
    • 42
    • 1
    Polyclonal
    Conjugate
    • 19
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UNC13B antibody is un-conjugated
    Application
    • 31
    • 26
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Cow (Bovine)
    Cross-Reactivity (Details)
    Mouse (99 %), Rat (98 %), Bovine (99 %)
    Characteristics
    Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans))
    UNC13B antibody [N3C1], Internal
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human UNC13B. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product UNC13B Primary Antibody
  • Application Notes
    Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Comment

    Positive Control: 293T , H1299 , HeLa , HepG2

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    UNC13B (Unc-13 Homolog B (UNC13B))
    Alternative Name
    UNC13B (UNC13B Products)
    Synonyms
    MUNC13 antibody, UNC13 antibody, Unc13h2 antibody, UNC13B antibody, Munc13-2 antibody, Munc13-1 antibody, Unc13a antibody, Unc13h1 antibody, unc-13 homolog B antibody, unc-13 homolog B (C. elegans) antibody, UNC13B antibody, Unc13b antibody
    Background
    This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

    Cellular Localization: Cytoplasm (By similarity) , Membrane, Peripheral membrane protein (By similarity) , Cell membrane (By similarity) , Cell junction , synapse (By similarity)
    Molecular Weight
    181 kDa
    Gene ID
    10497
    Pathways
    Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
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