UNC13B antibody (AA 1-350)

Catalog No. ABIN7271215

This Rabbit Polyclonal antibody specifically detects UNC13B in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for UNC13B antibody (AA 1-350) (ABIN7271215)

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UNC13B Antibody

Binding Specificity: AA 1-350

Purpose: UNC13B Rabbit pAb

Sequence: MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKDDEI CGTRNPTPHK ILLDTRFELP FDIPEEEARY WTYKWEQINA LGADNEYSSQ EESQRKPLPT AAAQCSFEDP DSAVDDRDSD YRSETSNSFP PPYHTASQPN ASVHQFPVPV RSPQQLLLQG SSRDSCNDSM QSYDLDYPER RAISPTSSSR YGSSCNVSQG SSQLSELDQY HEQDDDHRET DSIHSCHSSH SLSRDGQAGF GEQEKPLEVT GQAEKEAACE PKEMKEDATT HPPPDLVLQK

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_006368.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UNC13B

Target: UNC13B (Unc-13 Homolog B (UNC13B))

Alternative Name: UNC13B

Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.,UNC13B,MUNC13,UNC13,Unc13h2,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,UNC13B

Molecular Weight: 180kDa/182kDa

Gene ID: 10497

UniProt: O14795

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis