anti-CDK5R1 Antibodies

Protein Summary

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Alternative names and synonyms associated with CDK5R1

• cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1) antibody
• cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b) antibody
• cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1) antibody
• cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1) antibody
• cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L) antibody
• Show all gene names
• cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1) antibody

• CDK5P35 antibody
• Cdk5r antibody
• CDK5R1 antibody
• D11Bwg0379e antibody
• NCK5A antibody
• Show all synonym aliases
• p23 antibody
• p25 antibody
• P25/P35 antibody
• p35 antibody
• p35nck5a antibody
• Xp35.1 antibody
• zgc:92814 antibody

Protein level used designations for CDK5R1

CDK5 activator 1 , TPKII regulatory subunit , cyclin-dependent kinase 5 activator 1 , cyclin-dependent kinase 5 regulatory subunit 1 , neuronal CDK5 activator , regulatory partner for CDK5 kinase , tau protein kinase II 23kDa subunit , cyclin-dependent kinase 5 regulatory subunit , cyclin-dependent kinase 5, regulatory subunit 1 (p35) , p23 , tau protein kinase II 23 kDa subunit , cyclin-dependent kinase 5, regulatory subunit (p35) 1