CDK5R1 antibody (AA 99-307)

Catalog No. ABIN7266592

This Rabbit Polyclonal antibody specifically detects CDK5R1 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for CDK5R1 antibody (AA 99-307) (ABIN7266592)

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5R1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CDK5R1 Antibody

Binding Specificity: AA 99-307

Purpose: CDK5R1 Rabbit pAb

Sequence: AQPPPAQPPA PPASQLSGSQ TGGSSSVKKA PHPAVTSAGT PKRVIVQAST SELLRCLGEF LCRRCYRLKH LSPTDPVLWL RSVDRSLLLQ GWQDQGFITP ANVVFLYMLC RDVISSEVGS DHELQAVLLT CLYLSYSYMG NEISYPLKPF LVESCKEAFW DRCLSVINLM SSKMLQINAD PHYFTQVFSD LKNESGQEDK KRLLLGLDR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 99-307 of human CDK5R1 (NP_003876.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CDK5R1

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Alternative Name: CDK5R1

Background: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.,CDK5R1,CDK5P35,CDK5R,NCK5A,p23,p25,p35,p35nck5a,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,CDK5R1

Molecular Weight: 34kDa

Gene ID: 8851

UniProt: Q15078

Pathways: Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity