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USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse embryonic stem cells to maintain stemness.
the epigenetic status of Oct4 and Nanog genes confirm that pre-induced pluripotent stem cells belong to an RVTg+OCT4+NANOG- state
In mouse embryonic stem cells, Cops2 binds to Nanog protein and prevent the degradation of Nanog by the proteasome.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog, Oct4 (show POU5F1 Proteins), and Sox2 (show SOX2 Proteins).
Loss of phosphorylation enhances NANOG activity in reprogramming. Mutation S65A alone has the most significant impact on increasing NANOG reprogramming capacity.
Nanog, Oct4 (show POU5F1 Proteins) and Tet1 (show TET1 Proteins) interplay in establishing stem cell pluripotency has been described.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (show OTX2 Proteins)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (show MTA2 Proteins).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), and Nanog; Trim24 (show TRIM24 Proteins) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
A higher expression of the pluripotency factor NANOG.
The interaction of Nanog with the AR signaling axis might induce or contribute to Ovarian cancer stem cells regulation. In addition, androgen might promote stemness characteristics in ovarian cancer cells by activating the Nanog promoter
The results show that Nanog expression was related to HBsAg, differentiation, and TNM (show ODZ1 Proteins) stage in hepatocellular carcinoma (HCC (show FAM126A Proteins)). Nanog may be an unfavorable prognostic biomarker for HCC (show FAM126A Proteins).
NANOG might be a potential biomarker for early diagnosis of urothelial carcinoma of the bladder.
These results demonstrate that analysis of IHC expression patterns of MK and NANOG in pretreatment biopsy specimens during the work-up period can provide a more definitive prognosis prediction for each oral squamous cell carcinoma (OSCC) patient that can help clinicians to develop a more precise individual treatment modality.
Chicken egg-white extracts promote OCT4 and NANOG expression and telomeres growth in 293T cells.
Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue.
Data show that lung adenocarcinoma SPC-A1 cell differentiated by a two-stage induction (TSI) method lost stem cell characteristics, including absent expression of OCT4 and Nanog.
Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression.
our data suggest that 3D culture increases the expression of Nanog through the relaxation of actin cytoskeleton, which mediates reduced Suv39h1 (show SUV39H1 Proteins) and H3K9me3 levels.
NANOG was absent or very faint in OCT4 (show POU5F1 Proteins) knockout blastocysts.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Activin A (show INHBA Proteins) and overexpression of SMAD2 (show SMAD2 Proteins)/3 significantly promoted expressions of porcine NANOG and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (show POU5F1 Proteins) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (show POU5F1 Proteins), and E-CADHERIN (show CDH1 Proteins) in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.
NANOG and SOX2 (show SOX2 Proteins) expression inversely correlated with the DNA methylation (show HELLS Proteins) pattern in the promoter region
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
Nanog suppresses the expression of vasa (show DDX4 Proteins) by directly regulating nlk1 (show NLK Proteins) in the early zebrafish embryo
findings suggest that maternal Nanog coordinates several gene regulatory networks that shape the embryo during gastrulation.
These results indicate that zebrafish Nanog is necessary for proper yolk syncytial layer development but is not directly required for embryonic cell differentiation.
The authors show, at single-cell resolution in vivo, that Pou5f3 complexes with Nanog to pattern mesendoderm differentiation at the blastula stage.
Nanog has a role in supressing cell migration.
maternal Nanog, Pou5f1 (show POU5F1 Proteins) and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Proteins)-430 expression
Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog.
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeobox transcription factor NANOG
, Nanog homeobox
, nanog homeobox transcription factor
, homeodomain transcription factor Nanog
, LOW QUALITY PROTEIN: homeobox protein NANOG
, nanog homeobox
, ovary-expressed homeobox protein