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anti-Human CHRM1 Antibodies:
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Human Polyclonal CHRM1 Primary Antibody for ELISA, WB - ABIN188571
Fiedler, Nathanson: The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves. in Neuro-Signals 2011
Show all 2 Pubmed References
Dog (Canine) Polyclonal CHRM1 Primary Antibody for ELISA, WB - ABIN547746
Caccamo, Oddo, Billings, Green, Martinez-Coria, Fisher, LaFerla: M1 receptors play a central role in modulating AD-like pathology in transgenic mice. in Neuron 2006
Human Polyclonal CHRM1 Primary Antibody for ICC, IF - ABIN4336771
Molina, Rodriguez-Diaz, Fachado, Jacques-Silva, Berggren, Caicedo: Control of insulin secretion by cholinergic signaling in the human pancreatic islet. in Diabetes 2014
results suggest that the cyclic ADP-ribose signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors
We find that, as in V1, most parvalbumin neurons in MT express m1 AChRs but, unlike in V1, it appears that so do most excitatory neurons.
in aged female rhesus monkeys hippocampal M1 receptor function is associated with spatial learning and memory and circadian activity.
The study was focused on the human mAChR1 receptor for which a presumably reliable model was generated using the congener mAChR3 as the template along with a second less reliable model based on the distant beta2-AR template. The second model was then utilized to produce the chimeras by combining the conformations of its Pro-containing helices (i.e., TM4, TM5, TM6 and TM7 with 16 modeled chimeras).
he discovery of a receptor homolog of human mAChR1 on Acanthamoeba with future studies planned to show its expression and binding to cholinergic agonist and antagonist would help clarify its role in the biology of this protist pathogen.
Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.(
There were no significant associations between CHRM1 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.
changes in membrane cholesterol concentration differentially impact preferential and non-preferential M1 and M3 receptor signaling
The rs2067477 muscarinic M1 receptor genotype is associated with grey matter volume in schizophrenia.
crystal structures of the M1 and M4 muscarinic receptors bound to the inverse agonist, tiotropium
this study highlights how the properties of affinity and cooperativity can be differentially modified on a common structural scaffold and identifies molecular features that can be exploited to tailor the development of M1 mAChR-targeting PAMs.
CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.
the levels were comparable for complexes containing GluR2, GluR3 and GluR4 as well as 5-HT1A. Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 were significantly increased in male patients with AD.
We show that BQCA potentiates agonist-induced beta-arrestin recruitment to M1 mAChRs.
In patients with schizophrenia, both cell body staining and elevated M1 muscarinic receptor reactivity correlated with higher symptom scores.
demonstrate that activation of M1 muscarinic acetylcholine receptor augments the restitution of epithelial barrier function in T84 cell monolayers after ethanol-induced epithelial injury, via ERK-dependent phosphorylation of focal adhesion kinase
Mutation of amino acid residues that form the orthosteric binding pocket caused a loss of carbachol response that could be rescued by BQCA.
Results show that downregulation of cholinergic receptor M1 by histone H3K9me3 impairs calcium signally and contributes to the pathogenesis of Huntington's disease.
Decreased muscarinic M1 receptor radioligand binding is found in the cerebral cortex of schizophrenic patients.
M1-mAChRs function at both surface and intracellular sites in telencephalon neurons including the hippocampus
The fluorescent compounds inherit bitopic properties from a linker-guided positioning of their Bodipy moiety within the M1 allosteric vestibule.
Autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
A breakdown in gene promoter methylation control of CHRM1 expression contributes to the global pathophysiology of schizophrenia.
Results indicate that direct inhibition of acetylcholinesterase activity and up-regulation of m1 muscarinic acetylcholine receptor expression in the striatum might contribute to the beneficial effects of alpha-asarone on locomotor hyperactivity in Fmr1 knock out mice.
The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
The memory deficits in mouse prion disease were completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs. Furthermore, prolonged exposure to BQCA markedly extended the lifespan of diseased mice.
Data suggest that the inositol phosphate accumulation assay has utility for the evaluation of M1 muscarinic acetylcholine receptor activators in vivo.
determining the phosphorylation status of the M1 mAChR at Ser(228) not only provides a means of establishing receptor activation following drug treatment both in vitro and in vivo but also allows for the mapping of the activation status of the M1 mAChR in the hippocampus
This study showed that M1 receptor knockout mice have higher noradrenaline levels than that of the wildtype mice, in parallel to a decrease in IgG producing B cells.
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice
High M1 muscarinic receptor expression is associated with acute liver injury.
This study demonistrated that Expression of m1-type muscarinic acetylcholine receptors by parvalbumin-immunoreactive neurons in the primary visual cortex
The mm (chi(1) congruent with -60 degrees ; chi(2) congruent with -60 degrees ) and tp (chi(1) congruent with 180 degrees ; chi(2) congruent with +60 degrees ) rotamers were identified as the likely conduction-catalyzing conformations of the AChR's selectivity-filter glutamates.
the M3 receptor has a pro-inflammatory role in cigarette smoke-induced neutrophilia and cytokine release, yet M1 and M2 receptors have an anti-inflammatory role
The results of this study suggested that M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current.
mAChRs in mouse colonic epithelial cells consist of two subtypes, M1 (80 %) and M3 (20 %); The M1 subtype was likely to regulate epithelial chloride secretion negatively and was susceptible to inflammation
M1 receptor is co-localized with VGLUT2 on the intraganglionic laminar endings of esophagus.
Downregulation of M1 muscarinic receptor in klotho mutant mice and inactivation of the JAK2/STAT3 signaling axis plays a critical role in cognitive impairment.
In the prefrontal cortex, M1 receptor enhances cyclic AMP formation and signaling to the nucleus.
Structural rearrangement analysis by FRET revealed that Gq coupling stabilizes the active conformation of muscarinic M1 receptor.
a low concentration of N-methyl-d-aspartate causes long-lasting hippocampal cell damage and that endogenous acetylcholine plays, via muscarinic M(1) receptor, a rescuing role in the excitotoxicity-induced long-lasting hippocampal cell damage
These data suggest that M1R(-/-) mice display abnormal responding in the face of relatively preserved attention, learning and perception.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
muscarinic acetylcholine receptor M1
, muscarinic receptor
, cholinergic receptor, muscarinic 1
, acetylcholine receptor, muscarinic 1
, Cholinergic receptor, muscarin 1
, m1 muscarinic acetylcholine receptor protein
, AChR M1
, muscarinic acetylcholine receptor 1