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Delphilin is an actin nucleator that does not accelerate elongation. Delphilin exhibits a preference for actin isoforms, nucleating nonmuscle actin but not muscle actin.
delphilin isoforms with differential palmitoylation and clustering capabilities may provide two separate intracellular and surface GluRdelta2 pools and may control GluRdelta2 signaling in Purkinje cells
Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin.
A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice.
Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization.
Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons.
findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning
Glutamate receptor delta-2 (GRID2\; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006
, glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
, glutamate receptor, ionotropic, delta 2-interacting protein 1
, GluR-delta2 philic-protein