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anti-Rat (Rattus) GRIN2C Antibodies:
anti-Human GRIN2C Antibodies:
anti-Mouse (Murine) GRIN2C Antibodies:
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Mouse (Murine) Polyclonal GRIN2C Primary Antibody for WB - ABIN1881390
Krapivinsky, Krapivinsky, Manasian, Ivanov, Tyzio, Pellegrino, Ben-Ari, Clapham, Medina: The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. in Neuron 2003
Show all 3 Pubmed References
Rat (Rattus) Polyclonal GRIN2C Primary Antibody for IP, WB - ABIN361398
Wang, Imamura, Ishibashi, Chandana, Yamamoto, Noda: The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice. in Journal of neurochemistry 2010
ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia
Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface
NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.
The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C.
Reduction in NR1 and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.
TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers
The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former.
Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes.
Triheteromeric GluN1/GluN2A/GluN2C receptors are the predominant NMADRs in cerebellar granule cells and are co-expressed in those cells.
These data reveal a novel mechanism involving plastic modification of synaptically recruited T-type Ca(2+) channels and nucleus Reticularis thalami bursting and indicate a critical role for GluN2C-NMDARs in thalamocortical rhythmogenesis.
GluN2C has a very distinct function in the telencephalon compared to its role in other brain regions.
The results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders.
a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia.
The GluN2C subunit enhances ischemic stroke pathology by promoting neuronal dysfunction in the penumbra region.
glutamatergic glial transmission is sensed by neurons of the dorsal Suprachiasmatic nucleus via specific pre-synaptic NMDA receptor assemblies containing NR2C subunits.
Tuberless heterozygote Tsc1+/- mice show functional up-regulation of cortical GluN2C receptors in an mTOR-dependent manner, exhibit recurrent, unprovoked seizures during early postnatal life, that can be treated with GluN2C antagonists.
low rectification normally observed in the nucleus reticularis of the thalamus is due to NR2C
No differences in expression of NR2A, NR2C or NR2D are found in any brain region examined during ethanol consumption and acute ethanol withdrawal.
Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1.
Findings suggest a unique role of NR2C-containing receptors in associative and executive learning. NR2C knockout mice were found to exhibit deficits in fear acquisition and working memory.
indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C
Expression of GluRepsilon 3 is essential for postsynaptic localization and protein stability of the GluRzeta1 subunit.
The spiny stellate neurons of barrel cortex layer 4 functionally express NR2C subunits; this is the likely explanation for their ability to generate large NMDAR-mediated EPSPs that are effective at resting potential, without previous depolarization.
results show that the NR2C by NR2B subunit exchange in mice affects ACh content in two target areas of the nucleus basalis
Results suggest that the replacement of subunit NR2C by NR2B in juvenile mice increases anxiety- and fear-related behaviors possibly due to changes in frontal cortex serotonin and periaqueductal grey acetylcholine levels.
stimulation of NMDA receptors in conjunction with the AMPA receptor-mediated excitation of granule cells plays a key role in functional subunit switching of NMDA receptors in maturing granule cells at the physiological KCl concentration
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
, interleukin 12 receptor beta 2.b
, interleukin 12 receptor, beta 2a, like
, N-methyl-D-aspartate receptor subunit 2C
, ionotropic glutamate receptor subunit NR2C
, glutamate [NMDA] receptor subunit epsilon-3-like
, N-methyl D-aspartate receptor subtype 2C
, NMDA glutamate receptor
, glutamate [NMDA] receptor subunit epsilon-3
, glutamate receptor ionotropic, NMDA 2C
, glutamate receptor, ionotropic, NMDA2C