GRIN2C antibody (N-Term)

Catalog No. ABIN361398

Product Details anti-GRIN2C Antibody

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Binding Specificity: N-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2C antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: Specific for the ~140k NR2C subunit of the NMDA receptor. Also labels the ~180k NR2A and the ~180k NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Fusion protein from the N-terminal region of the NR2C subunit

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC, IF (frozen sections, unpublished observations): 1:1000 to 1:2000 IP: 3 µl per 200 µg lysate Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized

Storage: -20 °C

References for anti-GRIN2C antibody (ABIN361398)

Wang, Imamura, Ishibashi, Chandana, Yamamoto, Noda: "The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice." in: Journal of neurochemistry, (2010) (PubMed).

Target Details for GRIN2C

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Alternative Name: GRIN2C (GRIN2C Products)

Synonyms: GRIN2C antibody, NMDAR2C antibody, il12rb2l antibody, il-12rb2.b antibody, nr2c antibody, GluN2C antibody, NR2C antibody, glutamate ionotropic receptor NMDA type subunit 2C antibody, interleukin 12 receptor, beta 2a, like antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C S homeolog antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C antibody, glutamate receptor, ionotropic, NMDA2C (epsilon 3) antibody, GRIN2C antibody, il12rb2l antibody, grin2c.S antibody, grin2c antibody, Grin2c antibody

Background: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Anti-NMDA Receptor, NR2C Subunit Western blot of 10 ug of rat cerebellar lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor.

Molecular Weight: '140 kDa

Gene ID: 24411

UniProt: Q00961

Pathways: Synaptic Membrane