Browse our anti-CD4 (CD4) Antibodies

Mouse (Murine) CD4 Molecule (CD4) interaction partners

1. Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and Treg-specific demethylated region demethylation.

2. IL-27 induces IL-10 production in CD4 T cells during mouse cytomegalovirus infection.

3. Study identified the maturation enhancer E4m, validated its role in regulating CD4 expression, and isolate Bcl11b as an important activator for E4m.

4. Enhancers that regulate Cd4 expression perform multiple functions, including not only direct support of transcriptional activity, but also regulation of the gene's methylation state and entrainment of cis-elements that sustain expression after the cells exit the thymus.

5. data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N).

6. results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells

7. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

8. High-fat diet - induced type 2 diabetes decreases the number of ileum IL17/RORgammaT CD4 T cells.

9. Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression.

10. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck

11. This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages.

12. 5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation

13. Both type I CD8+ cytotoxic (Tc1) cells and interleukin (IL)-17-producing CD8+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 cells are superior to Tc17 cells in mediating tumor regression.

14. Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function.

15. Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals.

16. CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice.

17. galectin-1 inhibition reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence

18. Mice that lack the ability to make both CD8-positive and CD4-positive induced regulatory T (iTreg) cells have accelerated graft-vs-host-disease mortality compared with animals that are competent to make both iTreg populations.

19. Danazol induced prolonged cardiac allograft survival and generation of regulatory CD4(+) cells.

20. Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells.

Human CD4 Molecule (CD4) interaction partners

1. Breast cancer CD4, FOXP3, and CXCL13 contents were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR), and their influence on distant disease-free survival (DDFS) was examined using univariable and multivariable Cox regression and Kaplan-Meier estimates in the entire cohort and in selected molecular subgroups.

2. The primary role of the S(52,56) residues of Vpu in antagonism of CD4, GaLV Env, and BST-2/tetherin is to recruit the SCF/betaTrCP ubiquitin ligase.

3. CD4 receptor levels are very low in THP-1 differentiated cells and that this down-regulation of the virus receptor is the result of miR-221/miR-222 up-regulation during differentiation. In THP-1 cell line stably expressing a modified CD4 that is not modulated by miR-221/miR-222, productive HIV-1 infection occurs after cell differentiation.

4. These findings highlight regions of cross talk between gp120 and gp41 and identify heptad repeat region 1(HR1) residues that play important roles in regulating CD4-induced conformational changes in Env.

5. CD4(+) and CD19(+) peripheral lymphocytes of early stage AD patients exhibit mitochondrial depletion, as seen both at the level of DNA and protein

6. Human microRNAs-221 and -222 inhibit HIV-1 entry in macrophages by targeting the CD4 viral receptor.

7. CD4 has four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide bond. Reduction of D2 disulfide decreases the dynamics of its surrounding beta-strands. Favorable inward collapse of structure occurs around the D2 disulfide after reduction.

8. Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up

9. Our results indicate that CD4 expression and older age are adverse prognostic factors in wild-type NPM1, FLT3-ITD-negative CN-AML.

10. We investigated the prevalence, magnitude and phenotype of CTAg-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8(+) and CD4(+) T-cell responses against MAGE-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-gamma ELISPOT. Spontaneous T-cell immunity against CTAg proteins therefore develops in many patients with testicular cancer.

11. Depletion of the gamma2 or mu1A (AP1M1) subunits of AP-1, but not of gamma1 (AP1G1), precludes Nef-mediated lysosomal degradation of CD4.

12. findings provide a mechanistic explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretroviral drug development

13. Mouse leukemia cell lines that could express hCD4 and CCR5 were thus established to facilitate normal entry of HIV-1 so that a human CD4/CCR5 transgenic mice cell model can be used to investigate the transmission and pathogenesis of HIV/AIDS and potential antiviral drugs against this disease.

14. The percentage of lamina propia CD4+LAP+ cells is increased in active ulcerative colitis, showing reduced suppressor activity due to their increased proportion of intracellular IL-17 expression.

15. possible therapeutic targets for childhood severe asthmatics identified thru DNA microarray

16. The study gives insights into the role of CD4 on cell membrane mechanical characteristics.

17. A decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients.

18. Redox shuffling of the allosteric disulfide results in previously undescribed conformational changes in CD4 that are likely important for its interaction with its protein partners.

19. Increased levels of activated and highly susceptible HIV-1 target cells, reduced CD4 and enhanced CXCR4 cell surface expression, together with the high susceptibility to FAS-induced programmed cell death may contribute to the rapid CD4+ T cell depletion.

20. HRB knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu.

Pig (Porcine) CD4 Molecule (CD4) interaction partners

1. Results suggest that the SLA-DOB and CD4 genes and their genetic mutations can be considered as important candidate genes and mutations for the immunity of pregnant sows.

2. The genetic variability of the T-cell surface glycoprotein CD4 (CD4) gene is associated with immune response-related phenotypes in MeLiM (melanoblastoma-bearing Libechov minipig) strain, which is a model for spontaneous cutaneous melanoma development and regression in minipigs.

3. The frequency and expression of a CD4 variant in microminipigs are described.

4. These data help clarify the regulatory mechanism of DNA methylation of the CD4 gene in non-immune cell response to virus replication.

Cow (Bovine) CD4 Molecule (CD4) interaction partners

1. These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.

2. These results suggested that the SNPs in CD4 and STAT5b may be potential genetic markers for SCS and milk/protein yields selecting and warrant further functional research.

3. The DNA methylation level of the CD4 gene was strongly influenced by mastitis in Chinese Holstein cattle.

4. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population

Rhesus Monkey CD4 Molecule (CD4) interaction partners

1. The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.

Chimpanzee CD4 Molecule (CD4) interaction partners

1. study found noticeable variation in the first variable region V1 of CD4 and in intron six among the subspecies of chimpanzees.