Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CD4 antibody (CD4) (PE) Primary Antibody

CD4 Reactivity: Rat ICC, FACS, IHC Host: Mouse Monoclonal OX-35 PE
Pubmed (10 references)
Catalog No. ABIN2749065
$484.24
Plus shipping costs $45.00
0.1 mg
Shipping to: United States
Delivery in 5 to 7 Business Days
  • Target See all CD4 Antibodies
    CD4
    Reactivity
    • 393
    • 232
    • 130
    • 52
    • 25
    • 24
    • 20
    • 19
    • 18
    • 17
    • 17
    • 16
    • 11
    • 11
    • 11
    • 10
    • 10
    • 9
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 421
    • 141
    • 136
    • 4
    • 2
    • 2
    • 1
    Mouse
    Clonality
    • 569
    • 129
    • 4
    Monoclonal
    Conjugate
    • 233
    • 73
    • 60
    • 58
    • 34
    • 16
    • 13
    • 13
    • 12
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD4 antibody is conjugated to PE
    Application
    • 583
    • 150
    • 141
    • 128
    • 100
    • 97
    • 92
    • 42
    • 39
    • 35
    • 34
    • 32
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Specificity
    The mouse monoclonal antibody OX-35 reacts with an extracellular epitope of rat CD4 transmembrane glycoprotein (55 kDa).
    Cross-Reactivity (Details)
    Rat
    Immunogen
    MLR generated rat Th cells
    Clone
    OX-35
    Isotype
    IgG2a
  • Application Notes
    The reagent is designed for Flow Cytometry analysis.
    Comment

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Viel, Lemarié, Benkirane, Paradis, Schiffrin: "Immune regulation and vascular inflammation in genetic hypertension." in: American journal of physiology. Heart and circulatory physiology, Vol. 298, Issue 3, pp. H938-44, (2010) (PubMed).

    Monzon-Casanova, Steiniger, Schweigle, Clemen, Zdzieblo, Starick, Müller, Wang, Rhost, Cardell, Pyz, Herrmann: "CD1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation." in: PLoS ONE, Vol. 5, Issue 9, (2010) (PubMed).

    Baba, Iwasaki, Maruoka, Suzuki, Tomaru, Ikeda, Yoshiki, Kasahara, Ishizu: "Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 2999-3006, (2008) (PubMed).

    Ramiro-Puig, Pérez-Cano, Ramos-Romero, Pérez-Berezo, Castellote, Permanyer, Franch, Izquierdo-Pulido, Castell: "Intestinal immune system of young rats influenced by cocoa-enriched diet." in: The Journal of nutritional biochemistry, Vol. 19, Issue 8, pp. 555-65, (2008) (PubMed).

    Baba, Ishizu, Iwasaki, Suzuki, Tomaru, Ikeda, Yoshiki, Kasahara: "CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype." in: Blood, Vol. 107, Issue 5, pp. 2004-12, (2006) (PubMed).

    Gelderman, Hultqvist, Holmberg, Olofsson, Holmdahl: "T cell surface redox levels determine T cell reactivity and arthritis susceptibility." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 34, pp. 12831-6, (2006) (PubMed).

    Yan, Devos, Yu, Xia, Rutgeerts, Goebels, Segers, Lin, Vandeputte, Waer: "Pathogenesis of autoimmunity after xenogeneic thymus transplantation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5936-46, (2003) (PubMed).

    Salomon, Netzer, Wildbaum, Schif-Zuck, Maor, Karin: "Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 5, pp. 2685-93, (2002) (PubMed).

    Tsuji, Kawaguchi, Wada, Nagoya, Inobe, Yamashita, Ishii, Uede: "Adenovirus-mediated in vivo B7-1 gene transfer induces anti-tumor immunity against pre-established primary tumor and pulmonary metastasis of rat osteosarcoma." in: Cancer gene therapy, Vol. 9, Issue 9, pp. 747-55, (2002) (PubMed).

    Dragun, Lukitsch, Tullius, Qun, Park, Schneider, Luft, Haller: "Inhibition of intercellular adhesion molecule-1 with antisense deoxynucleotides prolongs renal isograft survival in the rat." in: Kidney international, Vol. 54, Issue 6, pp. 2113-22, (1999) (PubMed).

  • Target
    CD4
    Alternative Name
    CD4 (CD4 Products)
    Synonyms
    cd4, L3T4, Ly-4, CD4mut, W3/25, p55, CD4 molecule, carcinoembryonic antigen-related cell adhesion molecule 5, T-cell surface glycoprotein CD4, CD4 antigen, Cd4 molecule, CD4, LOC100125525, cd4, Cd4
    Background
    CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands, such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation, T/B-cell adhesion, T-cell differenciation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).
    Pathways
    TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
You are here:
Support