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Lck-CD8 interaction is required for initial CD8 recruitment.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
We propose that ADP-ribosylation of CD8-beta can regulate the coreceptor function of CD8 in the presence of elevated levels of extracellular NAD(+) .
Data indicate that CD8low cells survive long term in vivo.
sialylation in a discrete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental switch that affects ligand binding
Data demonstrate that major histocompatibility complex-I-signaled thymocytes appear as CD4+8lo cells because of transient down-regulation of CD8 gene expression, not because of changes in CD8 surface protein expression or distribution.
The stalk region of CD8 beta is capable of fine-tuning the coreceptor function of CD8 proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region.
results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression
The crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab at 2.7 A resolution, was elucidated.
The stalk region of CD8beta influences the ability of CD8 to bind class I major histocompatibility complexes and is therefore critical for the correct functioning of CD8alphabeta heterodimers.
Results identify novel functions for both CD8 and LAT during CD8-mediated apoptosis that are independent of TCR signal transduction and suggest a mechanism for signal transduction leading to apoptosis upon CD8 crosslinking.
The crystal structure of CD8alphabeta in complex with H-2Dd antigen indicates that CD8beta is crucial in orienting the CD8alphabeta heterodimer.
results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored
Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.
transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.
Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.
[review] Coreceptor CD8alphabeta contributes to the antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling.
A clustering of DNase hypersensitivity sites and matrix attachment regions capable of binding SATB1 and GATA-3, colocalized at the 3' end of the CD8B gene, suggests that this region is an epigenetic regulator of CD8 expression.
RT-PCR, and related methodologies are not useful substitutes for assessment of CD4 and CD8 cell numbers in HIV-infected persons.
study demonstrated differential mRNA expression patterns of CD8beta splice variants in thymocytes and in resting, memory, and activated primary CD8(+) T cells
Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
, CD8 beta-2
, T-cell surface glycoprotein CD8 beta chain
, CD8 antigen beta polypeptide
, T-cell membrane glycoprotein Ly-3
, T-cell surface glycoprotein Lyt-3
, lymphocyte antigen 3
, CD8 antigen, beta polypeptide 1 (p37)
, T lymphocyte surface glycoprotein beta chain
, CD8 antigen 37 kDa chain
, CD8 antigen beta-chain
, CD8 antigen, beta chain
, CD8 antigen, beta-chain
, OX-8 membrane antigen
, CD8 beta chain
, CD8 antigen, beta polypeptide
, CD8b antigen