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anti-Human CSK Antibodies:
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Chicken Monoclonal CSK Primary Antibody for IF, IP - ABIN967730
Bénistant, Bourgaux, Chapuis, Mottet, Roche, Bali: The COOH-terminal Src kinase Csk is a tumor antigen in human carcinoma. in Cancer research 2001
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Chicken Monoclonal CSK Primary Antibody for IF, IP - ABIN967731
Bergman, Mustelin, Oetken, Partanen, Flint, Amrein, Autero, Burn, Alitalo: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. in The EMBO journal 1992
Show all 5 Pubmed References
Human Monoclonal CSK Primary Antibody for ICC, FACS - ABIN969069
Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: Genome-wide association study of blood pressure and hypertension. ... in Nature genetics 2010
Show all 3 Pubmed References
Human Polyclonal CSK Primary Antibody for ICC, IF - ABIN4300691
Gallagher, Rambow, Kumasaka, Champeval, Bellacosa, Delmas, Larue: Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. in Oncogene 2013
Human Polyclonal CSK Primary Antibody for IHC (p), IHC - ABIN256941
Holtrich, Bräuninger, Strebhardt, Rübsamen-Waigmann: Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. in Proceedings of the National Academy of Sciences of the United States of America 1992
Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children.
H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src (show SRC Antibodies) at the tyrosine 530 residue resulting in a reduction of ERK1/2 (show MAPK1/3 Antibodies) phosphorylation.
Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma.
deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis
Our results do not support association between PTPN22 (show PTPN22 Antibodies)/CSK and Henoch-Schonlein purpura
Results identify CSK downregulation as a principal driver of SRC (show SRC Antibodies) activation and castration resistance.
Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population.
CSK is the kinase responsible for C-terminal phosphorylation of SRC (show SRC Antibodies), but not BRK (show PTK6 Antibodies).
Data indicate that the potent c-Src (show SRC Antibodies) inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma (show ARHGEF16 Antibodies) xenograft model.
Haemophilus ducreyi LspA1 protein inhibits phagocytosis by activation of host CSK.
Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (show SRC Antibodies), and these findings provide a novel therapeutic target for the treatment of hypertension
Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.
SHIP1 (show INPP5D Antibodies) and Csk are part of the PSTPIP2 (show PSTPIP2 Antibodies)-dependent inhibitory network that prevents the development of autoinflammatory disease.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.
Differentiation of embryonic stem cells is driven by c-Src (show SRC Antibodies) is antagonized by c-Yes (show YES1 Antibodies).
critical role in preventing TCR signaling
It was concluded that c-Src (show SRC Antibodies) and NADPH oxidase (show NOX1 Antibodies) components are necessary for redox-mediated production of TNF-alpha (show TNF Antibodies) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
The Csk pathway appears to be a critical signaling cascade regulating social learning and memory
Dok-4 (show DOK4 Antibodies) has a role as an anchoring molecule for the tyrosine kinase (show TYRO3 Antibodies) c-Src (show SRC Antibodies), and in turn as a regulator of TNF-alpha (show TNF Antibodies)-mediated ROS (show ROS1 Antibodies) production and NF-kappaB (show NFKB1 Antibodies) activation
Src (show SRC Antibodies) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (show NOS2 Antibodies) in pulmonary artery endothelium.
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
, protein-tyrosine kinase CYL
, tyrosine-protein kinase CSK
, protein-tyrosine kinase MPK-2
, C-SRC kinase
, protein-tyrosine kinase (CSK)
, protein kinase
, src kinase