anti-Inositol Polyphosphate-5-Phosphatase, 145kDa Antibodies

Protein Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D)

• inositol polyphosphate-5-phosphatase D (INPP5D) antibody
• phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100446045) antibody
• inositol polyphosphate-5-phosphatase D (inpp5d) antibody
• inositol polyphosphate 5-phosphatase (EHI_159880) antibody
• inositol polyphosphate 5-phosphatase (EHI_153490) antibody
• Show all gene names
• inositol polyphosphate-5-phosphatase D L homeolog (inpp5d.L) antibody
• phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100380693) antibody
• inositol polyphosphate-5-phosphatase D (Inpp5d) antibody

• 13.t00027 antibody
• 256.t00004 antibody
• AI323613 antibody
• hp51CN antibody
• INPP5D antibody
• Show all synonym aliases
• s-SHIP antibody
• SHIP antibody
• SHIP-1 antibody
• SHIP1 antibody
• SIP-145 antibody

Protein level used designations for INPP5D

inositol polyphosphate-5-phosphatase, 145kDa , SH2 containing inositol phosphatase , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like , SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SH2 domain-containing inositol-5'-phosphatase 1 , SHIP-1 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , SH2 containing inositol phosphotase , SH2-containing inositol phosphatase SHIP , SIP-145 , Src homology 2 domain-containing inositol-5-phosphatase , inositol polyphosphate-5-phosphatase of 145 kDa , inositol polyphosphate-5-phosphatase, 145 kDa , p150Ship , Inositol polyphosphate-5-phosphatase 145 kDa , Inositol polyphosphate-5-phosphatase, 145 kDa , signaling inositol polyphosphate 5 phosphatase SIP-145