Browse our anti-LAT (LAT) Antibodies

Full name:: anti-Linker For Activation of T Cells Antibodies (LAT)

On www.antibodies-online.com are 318 Linker For Activation of T Cells (LAT) Antibodies from 29 different suppliers available. Additionally we are shipping LAT Kits (31) and LAT Proteins (12) and many more products for this protein. A total of 373 LAT products are currently listed.

Synonyms:: lat, LAT1, pp36

list all antibodies	Gene Name	GeneID	UniProt
	LAT	27040	O43561
	LAT	81511	O70601
	LAT	16797	O54957
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Top referenced anti-LAT Antibodies

Human Monoclonal LAT Primary Antibody for ICS - ABIN1177077 : Cho, Velikovsky, Swaminathan, Houtman, Samelson, Mariuzza: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. in The EMBO journal 2004 (PubMed)
Show all 6 Pubmed References
Human Monoclonal LAT Primary Antibody for ICS - ABIN1177078 : Janssen, Zhang: Adaptor proteins in lymphocyte activation. in Current opinion in immunology 2003 (PubMed)
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Human Monoclonal LAT Primary Antibody for ICS - ABIN1177079 : Lin, Weiss: Identification of the minimal tyrosine residues required for linker for activation of T cell function. in The Journal of biological chemistry 2001 (PubMed)
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Human Monoclonal LAT Primary Antibody for ICS - ABIN1177080 : Paz, Wang, Clarke, Lu, Stokoe, Abo: Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. in The Biochemical journal 2001 (PubMed)
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Human Monoclonal LAT Primary Antibody for IHC (f), WB - ABIN967594 : Samelson: Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. in Annual review of immunology 2002 (PubMed)
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Human Monoclonal LAT Primary Antibody for ICS - ABIN1177082 : Zhu, Janssen, Zhang: Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. in Journal of immunology (Baltimore, Md. : 1950) 2002 (PubMed)
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Mouse (Murine) Monoclonal LAT Primary Antibody for ICC, IP - ABIN94420 : Tolar, T?mová, Dráber: New monoclonal antibodies recognizing the adaptor protein LAT. in Folia biologica 2001 (PubMed)
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Human Monoclonal LAT Primary Antibody for FACS, IP - ABIN302069 : Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. in Molecular and cellular biology 2007 (PubMed)
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Human Polyclonal LAT Primary Antibody for ELISA, WB - ABIN250250 : Finco, Kadlecek, Zhang, Samelson, Weiss: LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. in Immunity 1998 (PubMed)

More Antibodies against LAT Interaction Partners

Human Linker For Activation of T Cells (LAT) interaction partners

The dimerization-dependent, cooperative binding of the growth factor receptor-bound protein 2 (show GRB2 Antibodies) family to LAT (show ORC3 Antibodies) may increase antigen receptor sensitivity by reducing signalosome formation at incompletely phosphorylated linker of activated T cells LAT (show ORC3 Antibodies) molecules, thereby prioritizing the formation of complete signalosomes.
Nur77 (show NR4A1 Antibodies) suppresses CD4 (show CD4 Antibodies)(+) T cell proliferation and uncover a suppressive role for Irf4 (show IRF4 Antibodies) in TH2 polarization; halving Irf4 (show IRF4 Antibodies) gene-dosage leads to increases in GATA3 (show GATA3 Antibodies)(+) and IL-4 (show IL4 Antibodies)(+) cells.
LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytototoxicity
Here we report that phosphotyrosine-mediated assembly of adaptor protein LAT networks yields two distinct kinetic species of the Ras activator SOS
Overexpression of LAT (show ORC3 Antibodies) is associated with microcephaly.
LAT (show ORC3 Antibodies) and SLP-76 (show LCP2 Antibodies) are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
this study shows that inherited LAT (show ORC3 Antibodies) deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
This is the first report of a LAT (show ORC3 Antibodies)-related disease in humans, manifesting by a progressive combined immune deficiency with severe autoimmune disease.
Data show that LAT1 plays an important role in regulating the uptake of essential amino acids such as leucine into endometrial cancer cells. Increased ability of BCH (show CHN2 Antibodies) compared to LAT1 shRNA at inhibiting Ishikawa spheroid area suggests that other LAT (show ORC3 Antibodies) family members may also contribute to cell growth.
Data indicate that the T cell-specific adaptor protein (TSAd (show SH2D2A Antibodies)) SH2 domain interacts with CD6 antigen (show CD6 Antibodies) and linker for activation of T cells protein (LAT (show ORC3 Antibodies)) phosphotyrosine (pTyr) peptides.

Mouse (Murine) Linker For Activation of T Cells (LAT) interaction partners

this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
IFT20 (show IFT20 Antibodies) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (show MLXIP Antibodies)-155 regulates the delicate balance between PAK1 (show PAK1 Antibodies)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (show CD28 Antibodies) and the TCR complex regulate NF-kappaB (show NFKB1 Antibodies) via different signaling modules of GRB-2 (show GRB2 Antibodies)/VAV1 (show VAV1 Antibodies) and LAT/ADAP (show APP Antibodies) pathways respectively.
The result indicate that LAT-PLCg1 (show PLCG1 Antibodies) interaction is important for controlling IL-6 (show IL6 Antibodies) production by T cells and demonstrate a critical role of IL-6 (show IL6 Antibodies) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (show PLCG1 Antibodies) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (show PLCG1 Antibodies) in Dow2-induced anergic T cells. The novel CD3 (show CD3E Antibodies)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (show SOS1 Antibodies) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Antibodies)-Lat-SLP-76 (show LCP2 Antibodies) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (show PLCG1 Antibodies)) signaling may function differently in various subsets of gammadelta T cells.

LAT Antigen Profile

Antigen Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with LAT

linker for activation of T-cells (LAT) antibody
linker for activation of T cells (lat) antibody
linker for activation of T cells (Lat) antibody

lat antibody
LAT1 antibody
pp36 antibody

Protein level used designations for LAT

linker for activation of T cells , 36 kDa phospho-tyrosine adapter protein , 36 kDa phospho-tyrosine adaptor protein , linker for activation of T cells, transmembrane adaptor , linker for activation of T-cells family member 1 , p36-38 , pp36 , linker protein

GENE ID	SPECIES
704656	Macaca mulatta
743295	Pan troglodytes
100233211	Danio rerio
27040	Homo sapiens
81511	Rattus norvegicus
16797	Mus musculus
514735	Bos taurus
607947	Canis lupus familiaris

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Show all anti-Linker For Activation of T Cells (LAT) Antibodies with Pubmed References

Human Linker For Activation of T Cells (LAT) interaction partners

Mouse (Murine) Linker For Activation of T Cells (LAT) interaction partners

Antigen Summary

Alternative names and synonyms associated with LAT

Protein level used designations for LAT