Browse our anti-MALT1 (MALT1) Antibodies

Human Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1) interaction partners

1. MALT1 and TRAF6 (show TRAF6 Antibodies) cooperatively interact with CARMA1 (show CARD11 Antibodies)-BCL10 (show BCL10 Antibodies) filaments and form CARMA1 (show CARD11 Antibodies)-BCL10 (show BCL10 Antibodies)-MALT1-TRAF6 (show TRAF6 Antibodies) signalosome.

2. The results suggest that the involvement of MALT1 in DNA damage-induced NF-kappaB (show NFKB1 Antibodies) is through the recruitment of TRAF6 (show TRAF6 Antibodies).

3. A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX (show FOXP3 Antibodies)-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX (show FOXP3 Antibodies)-like syndrome associated with immunodeficiency.

4. Thrombin (show F2 Antibodies)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (show CYLD Antibodies) cleavage.

5. Authors utilized transcriptomic data and experimental evidences to prove that miR (show MLXIP Antibodies)-181d was a novel regulator of NFkappaB (show NFKB1 Antibodies) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (show ME1 Antibodies) genes.

6. Taken together, this present study indicates that miR (show MLXIP Antibodies)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.

7. These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.

8. MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (show CARD14 Antibodies)-induced cytokine and chemokine (show CCL1 Antibodies) expression in human primary keratinocytes.

9. results unveil HOIL1 (show RBCK1 Antibodies) as a negative regulator of lymphocyte activation cleaved by MALT1.

10. CARD14 (show CARD14 Antibodies)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]

Mouse (Murine) Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1) interaction partners

1. IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.

2. this study shows that Malt1 protease activity plays an important role in the activation of innate immune cells via FcgammaR, and the development of FcgammaR-mediated autoimmune diseases

3. the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection.

4. MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions.

5. Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (show NLRP3 Antibodies) inflammasome and NF-kappaB (show NFKB1 Antibodies) activation are critical components in MALT1 signaling cascades in this disease model.

6. Thrombin (show F2 Antibodies)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (show CYLD Antibodies) cleavage.

7. MALT1 function is required in B cells for germinal center formation.

8. Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)

9. Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)

10. TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.