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Human Monoclonal MALT1 Primary Antibody for IHC (p), WB - ABIN2475476
Pincus, Kahan, Mittal: A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens. in Immunochemistry 1976
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Mouse (Murine) Polyclonal MALT1 Primary Antibody for ELISA, WB - ABIN4332478
Rosebeck, Madden, Jin, Gu, Apel, Appert, Hamoudi, Noels, Sagaert, Van Loo, Baens, Du, Lucas, McAllister-Lucas: Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. in Science (New York, N.Y.) 2011
A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX (show FOXP3 Antibodies)-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX (show FOXP3 Antibodies)-like syndrome associated with immunodeficiency.
Thrombin (show F2 Antibodies)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (show CYLD Antibodies) cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR (show MLXIP Antibodies)-181d was a novel regulator of NFkappaB (show NFKB1 Antibodies) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (show ME1 Antibodies) genes.
Taken together, this present study indicates that miR (show MLXIP Antibodies)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (show CARD14 Antibodies)-induced cytokine and chemokine (show CCL1 Antibodies) expression in human primary keratinocytes.
results unveil HOIL1 (show RBCK1 Antibodies) as a negative regulator of lymphocyte activation cleaved by MALT1.
CARD14 (show CARD14 Antibodies)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]
Psoriasis mutations disrupt CARD14 (show CARD14 Antibodies) autoinhibition promoting BCL10 (show BCL10 Antibodies)-MALT1-dependent NF-kappaB (show NFKB1 Antibodies) activation
Studies indicate that t(11;18)(q21;q21) translocation involves MALT1 (MALT lymphoma translocation protein 1) gene.
the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection.
MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions.
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (show NLRP3 Antibodies) inflammasome and NF-kappaB (show NFKB1 Antibodies) activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1-dependent NF-kappaB (show NFKB1 Antibodies) activation is crucial for the development of EGFR (show EGFR Antibodies)-associated solid-tumor progression
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB (show NFKB1 Antibodies) pathway.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog