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The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.
RAS guanyl releasing protein 2
, RAS guanyl releasing protein 2, isoform 3
, F25B3.3 kinase-like protein
, RAS guanyl nucleotide-releasing protein 2
, RAS guanyl-releasing protein 2
, calcium and DAG-regulated guanine nucleotide exchange factor I
, calcium and diacylglycerol-regulated guanine nucleotide exchange factor I
, cdc25-like protein
, guanine exchange factor MCG7
, RAS, guanyl releasing protein 2
, calcium diacylglycerol guanine nucleotide exchange factor I
, F25B3.3 kinase like protein
, RAP 1A protein-specific guanine nucleotide exchange factor 1
, RAS, guanyl releasing protein 2; RAP 1A protein-specific guanine nucleotide exchange factor 1; CalDAG-GEFI