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anti-Human RASSF5 Antibodies:
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Human Polyclonal RASSF5 Primary Antibody for ICC, IF - ABIN4340365
Miertzschke, Stanley, Bunney, Rodrigues-Lima, Hogg, Katan: Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. in The Journal of biological chemistry 2007
Show all 2 Pubmed References
Human Polyclonal RASSF5 Primary Antibody for IF (cc), IF (p) - ABIN1386228
Yang, Kong, Jin, Hergovich, Püschel: Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway. in Journal of cell science 2014
Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL.
Hepatitis C virus uses NS5B to specifically suppress NORE1A, facilitating viral replication and elevated Ras signaling.
Our study demonstrated that miR-214 expression was elevated and RASSF5 was down regulated in oral cancer. Moreover, miR-214 suppressed KB cell apoptosis through down regulation of RASSF5 expression
mCD40L-induced cell death mediated by NORE1A expression appeared to be independent of mCD40L-induced cell death mediated by sustained JNK activation since NORE1A inhibition did not affect JNK phosphorylation and vice versa
Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation
Down-regulation of RASSF5A and RASSF5C expression is a tumor-specific phenomenon.
RASSF5 expression is negatively correlated with distant metastasis of osteosarcoma, and RASSF5 may function as a tumor suppressor in OS cells through activation of the MST1/LATS1 pathway.
NORE1A allows Ras to qualitatively modify p53 function to promote senescence.
the inactivation of RASSF5A through CpG island 1 methylation may play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis, RASSF5A may be a functional tumor suppressor and may serve as a prognostic biomarker for ESCC.
NORE1A has a role in Ras regulation of SCF(beta-TrCP) protein activity and specificity
RASSF5 can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation.
Ubiquitin ligase Itch is a unique negative regulator of RASSF5.
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.
crystal of NORE1 diffracted to 2.7 A resolution and belonged to space group P6(1)22, with unit-cell parameters a = b = 73.041, c = 66.092 A, alpha = beta = 90, gamma = 120 degrees
These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization.
N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL membrane and Rap1 binding and effectively substituted for PI3K and TCR ligation in the activation of LFA-1 in T cells.
NORE1A has activity that suppresses the centrosome amplification induced by HU and that NORE1A mRNA down-regulation is one of the common gene abnormalities in NSCLCs, both of which imply a key preventive role of NORE1A against the carcinogenesis of NSCLC.
epigenetic inactivation of NORE1 due to aberrant promoter hypermethylation is a frequent event in colorectal tumorigenesis and might be implicated in the malignant progression of colorectal tumors
a novel regulatory network composed of the tumor suppressor NORE1A, the mitotic kinase Aurora A, the small GTPase Ras, and the microtubule cytoskeleton.
findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation.
gene deficient mice experience age-related lupus-like glomerulonephritis and develope B cell lymphomas
a direct role for RASSF5 in death receptor ligand-mediated apoptosis and provide further evidence for RASSF5 as a tumor suppressor.
findings reveal the several critical steps of Rap1, which are RAPL-dependent and -independent, in lymphocyte trafficking
mapping to chromosome 1 and sequence variation of the murine Ras effector gene Nore1
Nore1 is a member of a family of Ras effector/tumor suppressors that includes RASSF1
RAPL is a crucial immune cell trafficking regulator essential for immunosurveillance.
RAPL and Mst1 localized to vesicular compartments and dynamically translocated with LFA-1 to the leading edge upon Rap1 activation.
nuclear export of NORE1A via nuclear export signal is involved in the NORE1A-mediated induction of apoptosis
Study describes the crystal structure of Ras in complex with the Ras binding domain (RBD) of NORE1A; the contact area of NORE1A is extended as compared with other Ras effectors & provides a rationale for an exceptionally long lifetime of the complex.
Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
, Ras association (RalGDS/AF-6) domain family 5
, Ras effector-like protein
, new ras effector 1
, novel Ras effector 1
, ras association domain-containing protein 5
, regulator for cell adhesion and polarization enriched in lymphoid tissue
, tumor suppressor RASSF3
, novel ras effector 1
, regulator for cell adhesion and polarization enriched in lymphoid tissues
, protein interacting with guanine nucleotide exchange factor